Late post-transplant anti-aquaporin-4 Ab-positive optic neuritis in a patient with AML

Diamanti, Luca; Franciotta, Diego; Berzero, Giulia; Bini, Paola; Farina, Lisa Maria; Colombo, Anna; Ceroni, Mauro; Marchioni, Enrico

doi:10.1038/bmt.2015.84

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…The temporal dynamics of this human autoimmunisation identified the generation of AQP4 antibodies over just a few weeks, early after stem cell transplantation and far more acutely than documented in two different clinical scenarios 2 3. An unusually sharp ~100-fold rise in naïve B cells occurred prior to generation of AQP4 antibodies.…”

Section: Discussionmentioning

confidence: 92%

“…Therefore, it may be that disordered STAT3 signalling, particularly from the recipient’s residual T cells, could be implicated in the pathogenesis of their NMOSD. 3 …”

Section: Discussionmentioning

confidence: 99%

“…To date, AQP4 antibodies and symptomatic NMOSD are known to develop several years after myasthenia gravis, typically post-thymectomy, 2 or in the context of bone marrow transplantation. 3 These examples suggest the immunopathogenesis of symptomatic NMOSD typically requires many years to mature.…”

Section: Introductionmentioning

confidence: 99%

“…Yet, the immunological mechanisms underlying the generation of AQP4 antibodies during disease initiation are incompletely understood, principally because this is an asymptomatic period. To date, AQP4 antibodies and symptomatic NMOSD are known to develop several years after myasthenia gravis, typically post-thymectomy,2 or in the context of bone marrow transplantation 3. These examples suggest the immunopathogenesis of symptomatic NMOSD typically requires many years to mature.…”

Section: Introductionmentioning

confidence: 99%

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Naïve B cells followed by aquaporin-4 antibodies characterise the onset of neuromyelitis optica: evidence from stem cell transplantation

McNaughton

Payne

Michael

et al. 2022

J Neurol Neurosurg Psychiatry

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Section: Discussionmentioning

confidence: 92%

“…Therefore, it may be that disordered STAT3 signalling, particularly from the recipient’s residual T cells, could be implicated in the pathogenesis of their NMOSD. 3 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Naïve B cells followed by aquaporin-4 antibodies characterise the onset of neuromyelitis optica: evidence from stem cell transplantation

McNaughton

Payne

Michael

et al. 2022

J Neurol Neurosurg Psychiatry

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“…MicroRNA-29b is downregulated in cerebral ischaemia and participates in the occurrence and development of cerebral ischaemia by targeting AQP4 regulation [22]. Furthermore, AQP4 induces paraneoplastic syndrome by antibody production, which may be the mechanism of acute myelogenous leukaemia coexisting with optic neuritis after transplantation [23]. At the same time, AQP4 has been demonstrated to be involved in cell proliferation, invasiveness, migration, and apoptotic potential in glioma cells [24].…”

Section: Discussionmentioning

confidence: 99%

Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis

Cai¹,

Yang²,

Jiang³

et al. 2020

CRJ

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Nasal-type NK/T-cell lymphoma (nasal-type NKTL) is one of the most lethal cancers for. Our study aimed to identify hub differentially expressed genes (DE-genes) and their upstream microRNAs between nasal-type NK/T-cell lymphoma (NKTL) tumor samples and normal nasal tissues through integrated bioinformatics. The 503 DE-genes and 106 DE-miRNAs were identified between NKTL and human normal nasal samples. GO and KEGG analysis were significantly enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, deubiquitination, enriched in meiotic recombination, regulation of syncytium formation by plasma membrane fusion, and stem cell division. And 11 differential expression hub genes and their upstream microRNAs were identified between nasal-type NKTL and normal nasal samples. In summary, after a series of analyses, we found that 11 hub DE-genes and their upstream DE-miRNAs (CDC27-miR-548c-3p, FREM2-miR-373 * , ARHGAP29-miR-548c-3p, QSER1-miR-548c-3p, CD3EAP-miR-149 * , between nasal-type NKTL and normal nasal samples. They are highly likely to be serve as promising biomarkers in nasal-type NKTL.

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Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls

et al. 2019

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Late post-transplant anti-aquaporin-4 Ab-positive optic neuritis in a patient with AML

Cited by 8 publications

References 10 publications

Naïve B cells followed by aquaporin-4 antibodies characterise the onset of neuromyelitis optica: evidence from stem cell transplantation

Naïve B cells followed by aquaporin-4 antibodies characterise the onset of neuromyelitis optica: evidence from stem cell transplantation

Identification of 11 Differentially Expressed Hub Genes and Their Upstream microRNAs in Nasal-type NK/T-cell Lymphoma Based on Clinical Sample Analysis

Diagnosing acute encephalitis in patients with hematological disorders: caveats and pitfalls

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