Late potentials and ventricular arrhythmias in acromegaly

Maffei, Pietro; Martini, Chiara; Milanesi, Anna; Corfini, Alberto; Mioni, Roberto; Carlo, Eugenio De; Menegazzo, Carla; Scanarini, M.; Vettor, Roberto; Federspil, Giovanni; Sicolo, Nicola

doi:10.1016/j.ijcard.2004.12.010

Cited by 40 publications

(37 citation statements)

References 25 publications

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“…17 Pathological ECGs even in patients with remission might point out irreversible fibrotic process and permanent arrhythmogenic pathways. 20 In a study by Maffei et al, late QT max: QT maximum, QT min: QT minimum, QTc: corrected QT potentials were reported not to be related with GH and IGF-1 levels, and they supposed that GH and IGF-1 play no role in arrhytmic process. 20 Fatti et al also detected no correlation between GH and IGF-1 levels, and pre-and post-treatment QTc intervals.…”

Section: Discussionmentioning

confidence: 98%

“…20 In a study by Maffei et al, late QT max: QT maximum, QT min: QT minimum, QTc: corrected QT potentials were reported not to be related with GH and IGF-1 levels, and they supposed that GH and IGF-1 play no role in arrhytmic process. 20 Fatti et al also detected no correlation between GH and IGF-1 levels, and pre-and post-treatment QTc intervals. 17 As consistent with Fatti et al, Unubol et al observed no correlation between GH and IGF-1, and QTc dispersion.…”

Section: Discussionmentioning

confidence: 98%

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The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

Başer¹,

Bayram²,

Polat³

et al. 2014

Acta Med Port

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Introduction: It was aimed to calculate QT intervals in patients with acromegaly and to reveal its correlation between QT intervals, and growth hormone and insulin like growth factor-1. Material and Methods: Forty-one patients with acromegaly were enrolled into the study. Another 41 individuals with similar features, such as comorbid diseases, age and sex constituted the control group. The electrocardiographies of patients with acromegaly were evaluated at the baseline and after the follow-up. Only one electrocardiography was performed for controls. QT maximum, QT minimum, QT dispersion, corrected QT maximum, corrected QT minimum and corrected QT dispersion were calculated. Results: Baseline QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion were significantly longer than the values of controls. Corrected QT maximum and corrected QT dispersion were significantly shorter after the follow-up, compared to the baseline in patients. QT maximum, QT dispersion, corrected QT maximum and corrected QT dispersion after the follow-up were not statistically different from the values of controls. Except the negative correlation between growth hormone and corrected QT dispersion in patients after the follow-up, no other correlation was detected between QT values and growth hormone or insulin like growth factor-1 levels. Corrected QT dispersion was found to be related with the disease duration in patients. Discussion: For acromegaly patients, it is important to detect clinical predictors of cardiac arrhytmias. QT dispersion is considered a beneficial predictor for ventricular arrhytmias. When compared to controls, prolonged QT intervals were determined in our acromegalic patients. Conclusion:We consider that QT intervals may also be utilized in the evaluation of increased cardiovascular risk in patients with acromegaly. Keywords: Acromegaly; Arrhythmias, Cardiac; Electrocardiography; Heart Rate. RESUMO

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

Başer¹,

Bayram²,

Polat³

et al. 2014

Acta Med Port

View full text Add to dashboard Cite

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“…It was found that late potentials were significantly higher in patients with acromegaly than in healthy subjects, a finding that was suggested to be attributable to growth hormone elevation seen in the patients with acromegaly. 3 In conclusion, either myocardial repolarization or depolarization abnormalities may account for the increased risk of ventricular arrhythmias in patients with AN, perhaps because of excess growth hormone. This relationship warrants additional evaluation in large-scale, prospective studies and may explain part of the increased cardiac complications seen in patients with AN.…”

Section: To the Editormentioning

confidence: 94%

Letter by Aparci et al Regarding Article, “Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa”

Aparcı

Kardeşoğlu

2016

Circulation

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“…Ventricular arrhythmias may occur due to excess or insuicient hormone activity on myocardial receptors, myocardial changes, electrolyte imbalances, or acceleration of progression of structural cardiac disorders [4]. Sudden death and increased prevalence of ventricular arrhythmias and LVPs have been described in acromegaly [34]. Ventricular arrhythmia risk in acromegaly is related to the speciic cardiomyopathy associated with left ventricular hypertrophy, myocardial ibrosis, comorbidities, especially hypertension and sleep apnea, and, possibly, to the direct efects of the growth hormone and insulin growth factor 1 on myocardial cells and cardiac ion channels [34,35].…”

Section: Interpreting Cardiac Electrograms -From Skin To Endocardiummentioning

confidence: 99%

“…Ventricular arrhythmia risk in acromegaly is related to the speciic cardiomyopathy associated with left ventricular hypertrophy, myocardial ibrosis, comorbidities, especially hypertension and sleep apnea, and, possibly, to the direct efects of the growth hormone and insulin growth factor 1 on myocardial cells and cardiac ion channels [34,35]. The prevalence of LVPs was signiicantly higher in patients with acromegaly compared to healthy controls, related to a longer duration of the disease, premature ventricular contractions, and left ventricular hypertrophy [34]. Herrmann et al…”

Section: Interpreting Cardiac Electrograms -From Skin To Endocardiummentioning

confidence: 99%

Signal-Averaged ECG: Basics to Current Issues

Mozoş¹,

Stoian²

2017

Interpreting Cardiac Electrograms - From Skin to Endocardium

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Signal-averaged ECG (SAECG) is a high-resolution, noninvasive electrocardiographic method enabling detection of late ventricular potentials (LVP), which are low-amplitude and high-frequency signals, predicting reentry ventricular arrhythmias, and sudden cardiac death (SCD). Three criteria are used to detect late ventricular potentials as follows: signal-average ECG QRS duration (SAECG-QRS), the duration of the terminal part of the QRS complex with an amplitude below 40 μV (LAS40) and the root mean square (RSM) signal amplitude of the last 40 ms of the signal < 20 μV (RMS40). Late ventricular potentials can be detected not only at the end of a QRS complex but also as intra-QRS (IQRS) potentials. Signal-averaged ECG was modiied to enable the analysis of the P-wave and to detect atrial late potentials (ALPs), low-amplitude potentials at the terminal part of the iltered P-wave, and predictors of atrial ibrillation (AF). Late atrial and ventricular potentials originate from areas of delayed, fragmented, and heterogenous conduction within atrial or ventricular myocardium. This chapter reviews the most important mechanisms explaining the occurrence of late ventricular, intra-QRS, and atrial potentials; their predictive value for arrhythmia, focusing on recent clinical data, long-term follow-up, and outcome; and analysis of SAECG variables in cardiac and noncardiac diseases.

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Late potentials and ventricular arrhythmias in acromegaly

Cited by 40 publications

References 25 publications

The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

The Evaluation of QT Intervals During Diagnosis and After Follow-Up in Acromegaly Patients

Letter by Aparci et al Regarding Article, “Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa”

Signal-Averaged ECG: Basics to Current Issues

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