Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors

Steineck, Gunnar; Sjöberg, Fei; Skokic, Viktor; Bull, Cecilia; Wilderäng, Ulrica; Alevronta, Eleftheria; Dunberger, Gail; Bergmark, Karin; Jörnsten, Rebecka

doi:10.1080/0284186x.2017.1307519

Cited by 9 publications

(11 citation statements)

References 22 publications

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“…Symptoms from the pelvic region originated predominantly from the bowels, the urinary tract, the lymphatic system and the genitals (Alevronta et al., ; Bergmark, Åvall‐Lundqvist, Dickman, Henningsohn, & Steineck, , ; Dunberger et al., ; Liavaag, Dørum, Fosså, Tropé, & Dahl, ; Lind et al., , ; Lindgren et al., ; Mikkelsen, Sørensen, & Dieperink, ; Mouritsen et al., ; Nesvold & Fosså, ; Steineck et al., , ; Vistad, Cvancarova, Fosså, & Kristensen, ). Bowel symptoms, such as diarrhoea, were experienced more often by gynaecological cancer survivors than by noncancer controls (Nord, Mykletun, Thorsen, Bjøro, & Fosså, ).…”

Section: Resultsmentioning

confidence: 99%

“…Symptoms from the pelvic region originated predominantly from the bowels, the urinary tract, the lymphatic system and the genitals Bergmark, Åvall-Lundqvist, Dickman, Henningsohn, & Steineck, 1999Dunberger et al, 2013;Liavaag, Dørum, Fosså, Tropé, & Dahl, 2009;Lind et al, 2011Lind et al, , 2016Lindgren et al, 2017;Mikkelsen, Sørensen, & Dieperink, 2017;Mouritsen et al, 2013;Nesvold & Fosså, 2002;Steineck et al, 2017aSteineck et al, , 2017bVistad, Cvancarova, Fosså, & Kristensen, 2008).…”

Section: Physical Well-being In a Changed Bodymentioning

confidence: 99%

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Lived experiences and quality of life after gynaecological cancer—An integrative review

Sekse

Dunberger²,

Olesen

et al. 2019

Journal of Clinical Nursing

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Aim and objectives To review the literature on Nordic women's lived experiences and quality of life (QoL) after gynaecological cancer treatment. Background While incidence and survival are increasing in all groups of gynaecological cancers in the Nordic countries, inpatient hospitalisation has become shorter in relation to treatment. This has increased the need for follow‐up and rehabilitation. Design Integrative literature review using the Equator PRISMA guidelines. Methods The review was selected, allowing inclusion of both experimental and nonexperimental research. The search included peer‐reviewed articles published 1995–2017. To frame the search strategy, we applied the concept of rehabilitation, which holds a holistic perspective on health. Results Fifty‐five articles were included and were contextualised within three themes. Physical well-being in a changed body encompasses bodily changes comprising menopausal symptoms, a changed sexual life, complications in bowels, urinary tract, lymphoedema and pain, bodily‐based preparedness and fear of recurrence. Mental well-being as a woman deals with questioned womanliness, the experience of revitalised values in life, and challenges of how to come to terms with oneself after cancer treatment. Psychosocial well-being and interaction deals with the importance of having a partner or close person in the process of coming to terms with oneself after cancer. Furthermore, the women needed conversations with health professionals around the process of coping with changes and late effects, including intimate and sensitive issues. Conclusion Years after gynaecological cancer, women have to deal with fundamental changes and challenges concerning their physical, mental and psychosocial well‐being. Future research should focus on how follow‐up programmes can be organised to target the multidimensional aspects of women's QoL. Research collaboration across Nordic countries on rehabilitation needs and intervention is timely and welcomed. Relevance to clinical practice To ensure that all aspects of cancer rehabilitation are being addressed, we suggest that the individual woman is offered an active role in her follow‐up.

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Section: Resultsmentioning

confidence: 99%

Section: Physical Well-being In a Changed Bodymentioning

confidence: 99%

Lived experiences and quality of life after gynaecological cancer—An integrative review

Sekse

Dunberger²,

Olesen

et al. 2019

Journal of Clinical Nursing

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“…There are several potential weaknesses in this study. These include the study of a relatively small sample of patients retrospectively which hampers meaningful subgroup analyses based on the five previously described late radiation-induced bowel syndromes [23] and the derivation of the radiation dose volume parameters of the OARs based on a single planning CT scan of the pelvis previously reported to be problematic in the proper understanding of dose volume relationships of OARs at risk of late GI toxicity [24]. However, we believe that these are outweighed by the strengths which include (i) a standard treatment technique of the patients and follow-up protocol by a single tertiary institution based radiation oncologist, (ii) comparisons of the data with a population of age matched patients before radiotherapy for carcinoma of the prostate although comparisons with the baseline data of the same patient group would have been preferable and (iii) meaningful significant relationships between the modified LENT-SOMA urgency of defecation, mucous discharge scores and anorectal motor function parameters which not only confirms previous reports that weakness of the IAS and EAS contribute to anorectal dysfunction [7,8,14] but also suggests that the underlying etiology of the weakness is neurogenic.…”

Section: Discussionmentioning

confidence: 99%

Pudendal nerve injury impairs anorectal function and health related quality of life measures ≥2 years after 3D conformal radiotherapy for prostate cancer

et al. 2017

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“…Late side effects such as fibrosis, atrophy, vascular damage, and nerve damage tend to be irreversible and often progressive. Cancer survivors who have undergone pelvic radiotherapy for gynecological or other pelvic cancers, such as rectal or anal cancer, may have persistent symptoms for many years, possibly even lifelong, after cancer therapy (5,56,61).…”

Section: Pelvic Cancer Treatmentmentioning

confidence: 99%

Incontinence, physical activity, and pelvic floor muscle training in female pelvic cancer survivors after radiotherapy

Lindgren

2020

Linköping University Medical Dissertations

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Background: Cancer treatment continues to improve, contributing to an evergrowing population of cancer survivors. Pelvic cancer survivors (PCS) constitute the second largest group of female cancer survivors after breast cancer. Many female PCS have been treated with radiotherapy as a part of their cancer treatment. Unfortunately, like all effective cancer treatments, pelvic radiotherapy is associated with a risk of subsequent, unwanted side effects. Some side effects remain or persist long after the end of treatment and some are even lifelong. A common and burdensome side effect after pelvic radiotherapy is urinary and/or fecal incontinence. Incontinence is known to negatively affect quality of life (QoL) and physical activity levels. Physical activity contributes to several positive health effects. In cancer survivors, it may reduce the risk of recurrence and even the mortality risk. Cancer survivors in general, and female PCS in particular, tend to be less physically active after cancer treatment than before treatment. When suffering from urinary and even fecal incontinence, pelvic floor muscle training (PFMT) is recommended as a first-line treatment for the general population. In addition to decreased incontinence levels, PFMT may contribute to increased physical activity and better QoL. However, little attention is given to PFMT as a potential treatment for incontinence in the Swedish national care program for pelvic cancer rehabilitation. Furthermore, there is as yet no evidence that PFMT is as effective in female PCS as in female non-cancer survivors. The effectiveness of PFMT cannot be taken for granted because female PCS survivors often have treatment-induced damage to structures in the pelvic floor that might affect its applicability. However, the problem of incontinence among female PCS remains, along with the fact that they tend to be less physically active than other cancer survivors. Indeed, this is an important research area and a necessary problem for health-care providers to resolve, not least for physiotherapists. Aim: The overall aim of this thesis is to improve the understanding of female PCS' experiences of incontinence in relation to physical activity, QoL, and rehabilitative efforts, including PFMT. This includes gaining increased knowledge about the relation between incontinence and physical activity in the form of exercise and QoL, and whether PCS experience that physiotherapy contributes in a valuable way to reducing their incontinence. This could enable the development of meaningful physiotherapeutic interventions, that PCS can and are willing to engage in, to achieve a potential reduction in incontinence, as well as increased QoL and activity levels. Methods: The thesis includes four different studies, using three different methods, all conducted with female PCS. Studies I (n=13) and IV (n=11) are qualitative individual interview studies, using semi-structured interview guides. Study II is a cohort-based cross-sectional observational study (n=578) and Study III is a prospective cohort-b...

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Late radiation-induced bowel syndromes, tobacco smoking, age at treatment and time since treatment – gynecological cancer survivors

Cited by 9 publications

References 22 publications

Lived experiences and quality of life after gynaecological cancer—An integrative review

Lived experiences and quality of life after gynaecological cancer—An integrative review

Pudendal nerve injury impairs anorectal function and health related quality of life measures ≥2 years after 3D conformal radiotherapy for prostate cancer

Incontinence, physical activity, and pelvic floor muscle training in female pelvic cancer survivors after radiotherapy

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