Late rectal bleeding after conformal radiotherapy of prostate cancer (II): volume effects and dose–volume histograms

In this study, we present an intensity‐modulated radiotherapy technique based on forward planning dose calculations to provide a concave dose distribution to the prostate and seminal vesicles by means of modified dynamic arc therapy (M‐DAT). Dynamic arcs (350 degrees) conforming to the beam's eye view of the prostate and seminal vesicles while shielding the rectum, combined with two lateral oblique conformal fields (15 degrees with respect to laterals) fitting the prostate only, were applied to deliver doses of 78 Gy and 61.23 Gy in 39 fractions to the prostate and seminal vesicles respectively. Dynamic wedges (45 degrees of thick end, anteriorly oriented) were used with conformal beams to adjust the dose homogeneity to the prostate, although in some cases, hard wedges (30 degrees of thick part, inferiorly oriented) were used with arcs to adjust the dose coverage to the seminal vesicles. The M‐DAT was applied to 10 patients in supine and 10 patients in prone positioning to determine the proper patient positioning for optimum protection of the rectum. The M‐DAT was compared with the simplified intensity‐modulated arc therapy (SIMAT) technique, composed of three phases of bilateral dynamic arcs. The mean rectal dose in M‐DAT for prone patients was 22.5±5.1 Gy; in M‐DAT and SIMAT for supine patients, it was 30.2±5.1 Gy and 39.4±6.0 Gy respectively. The doses to 15%, 25%, 35%, and 50% of the rectum volume in M‐DAT for prone patients were 44.5±10.2 Gy, 33.0±8.2 Gy, 25.3±6.4 Gy, and 16.3±5.6 Gy respectively. These values were lower than those in M‐DAT and in SIMAT for supine patients by 7.7%, 18.2%, 22.4%, and 28.5% and by 25.0%, 32.1%, 34.9%, and 41.9% of the prescribed dose (78 Gy) respectively. Ion chamber measurements showed good agreement of the calculated and measured isocentric dose (maximum deviation of 3.5%). Accuracy of the dose distribution calculation was evaluated by film dosimetry using a gamma index, allowing 3% dose variation and 4 mm distance to agreement as the individual acceptance criteria in prostate and seminal vesicle levels alike for all supine and prone patients. We found that fewer than 10% of the pixels in the dose distribution of the calculated area of 10×10−cm failed the acceptance criteria. These pixels were observed mainly in the low‐dose regions, particularly at the level of the seminal vesicles.In conclusion, the single‐phase M‐DAT technique with patients in the prone position was found to provide the intended coverage of the prescribed doses to the prostate and seminal vesicles with improved protection for the rectum. Accordingly, M‐DAT has replaced non‐modulated conformal radiotherapy or SIMAT as the standard treatment for prostate cancer in our department.PACS number: 87.53.Tf

Section: Resultssupporting

confidence: 82%

Forward‐planning intensity‐modulated radiotherapy technique for prostate cancer

Metwaly

Awaad

El-Sayed

et al. 2007

“…Although 3D‐CRT and IMRT have reduced the morbidity of prostate radiotherapy, the incidence of late rectal bleeding/injury has been shown to increase as the prescription dose rises above 70 Gy (16) (17) Several studies ( 16 – 21 ) have also indicated that volume effects may influence the incidence of chronic rectal injuries. The percentage volume of the rectum exposed to doses between 40 Gy and 50 Gy and the existence of a reserve of unexposed tissue also play a role in the development of late rectal injury (16) .…”

Section: Introductionmentioning

confidence: 99%

“…, (17) Several studies ( 16 – 21 ) have also indicated that volume effects may influence the incidence of chronic rectal injuries. The percentage volume of the rectum exposed to doses between 40 Gy and 50 Gy and the existence of a reserve of unexposed tissue also play a role in the development of late rectal injury (16) . These studies suggest that late rectal bleeding/injury is a dose‐limiting complication in prostate radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Stereotactic IMRT for prostate cancer: Dosimetric impact of multileaf collimator leaf width in the treatment of prostate cancer with IMRT

Wang

Movsas

Jacob

et al. 2004

The focus of this work is the dosimetric impact of multileaf collimator (MLC) leaf width on the treatment of prostate cancer with intensity‐modulated radiation therapy (IMRT). Ten patients with prostate cancer were planned for IMRT delivery using two different MLC leaf widths—4 mm and 10 mm— representing the Radionics micro‐multileaf collimator (mMLC) and Siemens MLC, respectively. Treatment planning was performed on the XKnifeRT2 treatment‐planning system (Radionics, Burlington, MA). All beams and optimization parameters were identical for the mMLC and MLC plans. All the plans were normalized to ensure that 95% of the planning target volume (PTV) received 100% of the prescribed dose. The differences in dose distribution between the two different plans were assessed by dose–volume histogram (DVH) analysis of the target and critical organs. We specifically compared the volume of rectum receiving 40 Gy (V40), 50 Gy (V50), 60 Gy (V60), the dose received by 17% and 35% of rectum (D17 and D35), and the maximum dose to 1 cm3 of the rectum for a prescription dose of 74 Gy. For the urinary bladder, the dose received by 25% of bladder (D25), V40, and the maximum dose to 1 cm3 of the organ were recorded. For PTV we compared the maximum dose to the “hottest” 1 cm3 (Dmax1cm3) and the dose to 99% of the PTV (D99). The dose inhomogeneity in the target, defined as the ratio of the difference in Dmax1cm3 and D99 to the prescribed dose, was also compared between the two plans. In all cases studied, significant reductions in the volume of rectum receiving doses less than 65 Gy were seen using the mMLC. The average decrease in the volume of the rectum receiving 40 Gy, 50 Gy, and 60 Gy using the mMLC plans was 40.2%, 33.4%, and 17.7%, respectively, with p<0.0001 for V40 and V50 and p<0.012 for V60. The mean dose reductions for D17 and D35 for the rectum using the mMLC were 20.4% (p<0.0001) and 18.3% (p<0.0002), respectively. There were consistent reductions in all dose indices studied for the bladder. The target dose inhomogeneity was improved in the mMLC plans by an average of 29%. In the high‐dose range, there was no significant difference in the dose deposited in the “hottest” 1 cm3 of the rectum between the two plans for all cases (p>0.78). In conclusion, the use of the mMLC for IMRT of the prostate resulted in significant improvement in the DVH parameters of the prostate and critical organs, which may improve the therapeutic ratio.PACS number: 87.53.Tf

“…These reductions in rectal doses may reduce chronic rectal injuries with these techniques, as suggested by several studies. ( 24 – 26 ) …”

Section: Resultsmentioning

confidence: 99%

Comparison of intensity‐modulated radiotherapy and forward‐planning dynamic arc therapy techniques for prostate cancer

Metwaly

Awaad

El-Sayed

et al. 2008

We compare an inverse‐planning intensity‐modulated radiotherapy (IMRT) technique with three previously published forward‐planning dynamic arc therapy techniques and a newly implemented technique for treatment of prostate only. The three previously published dynamic arc techniques are dynamic arc therapy (DAT), two‐axis dynamic arc therapy (2A‐DAT), and modified dynamic arc therapy (M‐DAT). The newly implemented technique is the bilateral wedged dynamic arc (BW‐DAT). In all dynamic arcs, the multileaf collimator is moving during rotation to fit the prostate, except that, in 2A‐DAT, it is fitting two separate symmetrical rhombi including the prostate. The rectum is shielded during rotation only in the cases of M‐DAT and BW‐DAT.The results obtained indicate that the BW‐DAT, M‐DAT, and DAT techniques provide the intended dose coverage of the prescribed dose to the planning target volume (PTV)—that is, 95% of the PTV is covered by 100% of the dose. The maximum dose to a 3‐cm margin of healthy tissue that surrounds the PTV is lower by 2.5% in the case of IMRT than in both BW‐DAT and M‐DAT, but it is lower by 5.0% than that in both DAT and 2A‐DAT. The maximum dose to the rest of the healthy tissue in the case of BW‐DAT is 33.2Gy±2.2Gy. This dose covers percentage healthy body volumes of 8%±3.2% with IMRT, 4%±1.5% with DAT, and 6%±1.2% with both 2A‐DAT and M‐DAT. Also, this dose is much lower than the accepted maximum dose (52 Gy) to the femoral heads and necks according to Report 62 from the International Commission on Radiation Units and Measurements. Accordingly, it would be possible to neglect delineation of the femoral heads and necks as organs at risk in cases of BW‐DAT.Doses to 15%, 25%, 35%, and 50% (D15%, D25%, D35%, and D50%) of the rectum volume in the case of BW‐DAT were 43.5Gy±8.6Gy, 24.2Gy±8.7Gy, 13.2Gy±4.2Gy, and 5.7Gy±2.1Gy respectively. The D15% of rectum in the case of IMRT was lower than that in BW‐DAT, M‐DAT, 2A‐DAT, and DAT by 7.3%, 10.3%, 33.0%, and 17.6% of the prescribed dose (78 Gy in 39 fractions) respectively. The D25%, D35%, and D50% of the rectum volume in the cases of IMRT and DAT were comparable (with a maximum variation of 4.5%); they were similarly comparable in the cases of M‐DAT and BW‐DAT (with maximum variation of 1.5%). These same doses in BW‐DAT were lower than those in IMRT by 8.7%, 10.6%, and 6.2% respectively, but they were quite lower than those in 2A‐DAT, because the average variation was 41.6% (with a maximum of 44.0%).The D15%, D25%, D35%, and D50% of the bladder volume in the case of BW‐DAT were 33.2Gy±10.9Gy, 17.4Gy±7.9Gy, 6.5Gy±4.3Gy, and 4.2Gy±3.5Gy respectively. The D15% and D25% of the bladder in the cases of IMRT, M‐DAT, and BW‐DAT were comparable (with a maximum variation of 2.2% and 3.6% respectively), and the mean values of each dose were lower in DAT by 14.3% and 11.7% respectively. However, the values of D35% and D50% in the four techniques were comparable, with maximum variations of 5.1% and 2.7% respectively. The D15%, D25%, D35%, and D50% of the bladder in the ...