Late recurrence in orbital rhabdomyosarcoma: Complete remission after multimodality management

Abstract

A case of orbital rhabdomyosarcoma had a localised recurrence 13 years after being treated with chemo radiotherapy. Late recurrences are rare in orbital RMS. Only two cases have been reported to have recurred after five years of follow up. Pathological similarity of both the lesions and occurrence outside the irradiated field excluded a radiation-induced second neoplasm. Immunohistochemistry staining with p 53 was positive. Patient had good response to chemotherapy and radiotherapy. Surgical resection of residue showed complete necrosis. Retreatment with combined modality therapy resulted in complete remission and the patient is on follow up.

Orbital Rhabdomyosarcoma: Current Perspectives

“…Recently new technologies in radiation oncology are used including proton beam radiotherapy, intensity modulated radiotherapy (IMRT), 3-D conformational radiotherapy and implant brachytherapy, this therapies tend to offer an excellent survival, to reduce dose to normal tissue adjacent and to decrease the long term side effects of treatment [38].…”

Late dental and bone alterations in patients after orbital rhabdomyosarcoma treatment

“…[14] Despite technological advances, children with orbit rhabdomyosarcoma submitted to multimodal treatment (surgery, chemotherapy and radiotherapy) still present signi cant alterations in teeth and facial bones in development. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] In this scenario, the most prevalent dental changes are root shortening (14.6%), agenesis (14.3%), and microdontia (13.6%). Risk factors have been associated with these alterations such as younger age at diagnosis (< 3 years), irradiated area, and dose-dependent alkylating agent therapy.…”