Late recurrence of left atrial myxoma with multiple intracranial aneurysms

Multiple Fusiform Cerebral Aneurysms and Highly Elevated Serum Interleukin-6 in Cardiac Myxoma

“…Although the pathogenesis of aneurysm formation in CM is not fully understood, radiological characteristics of cerebral aneurysms associated with CM are similar to those of emboli in choriocarcinoma or infective endocarditis, suggesting that aneurismal formation in CM is not caused by intracerebral hemodynamic change, but direct myxomatous cell invasion into the vessel wall 2) . Embolization of the myxomatous cell to the intracranial vasculature occurred, with tumor cells lodging in the distal intracranial arteries 10) . With the ability of mitotic and proliferating activity within the vessel, myxomatous cells can penetrate the vessel wall and infiltrate the internal elastic lamina, subsequently leading to weakening of the subintimal wall.…”

Rupture of Cerebral Myxomatous Aneurysm Months After Resection of the Primary Cardiac Tumor

“…Myxomatous aneurysms have been reported to occur in patients of all ages and are twice as common in females, similar to the trend in non-myxomatous cerebral aneurysms [18]. The most common morphology of myxomatous aneurysms is fusiform, although saccular aneurysms have been reported [1,3,[17][18][19]. Myxomatous aneurysms are strictly pseudoaneurysms, i.e., they do not involve all three layers of the artery.…”

“…Sabolek et al [18] reported that 56% of patients presented with aneurysms prior to cardiac surgery, but the remainder presented after cardiac myxoma resection, in some cases years after resection. Yilmaz et al [19] described a young woman who presented with pathologically proven myxomatous cerebral aneurysms, both saccular and fusiform, 25 years after the initial cardiac presentation. Given the variability in time course from cardiac resection to neurological presentation, the rate at which myxomatous aneurysms enlarge must be unpredictable, and is not well known.…”

“…MR of the brain may disclose an inflammatory reaction in parenchyma underlying a myxomatous aneurysm, and can guide angiography. By analogy with un-ruptured non-myxomatous aneurysms, aneurysm enlargement may warrant consideration for treatment [5,19,[26][27][28].…”

Right atrial myxoma with tumor vascularity originated from the left and right coronary arteries

“…Atrial myxoma is a most frequent tumor in the heart; approximately 50% of cardiac tumor is atrial myxoma [1,2]. "Tumor blush" is known as an angiographic feature of cardiac myxoma [3].…”