Late Recurrence of Low-Risk Stage II Colorectal Cancer Shortly After Etanercept

Ibrahim, Tony; Saleh, Khalil; Track-Smayra, Viviane; Ziadé, Nelly; Sarraf, Dalia; Yazbeck, Charbel; Khalifé, Nadine; Nasr, Fadi

doi:10.1007/s12029-015-9788-y

Cited by 2 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Moreover, it has been reported that patients who were treated longer than 12 months with TNF-α inhibitors had an increased risk for various malignancies including colorectal cancer. 18 20 Colorectal cancer has also been reported as an adverse effect in psoriasis patients treated with ustekinumab. 21 Therefore, risk factors for malignancy should be determined in all patients with psoriasis before the initiation of biological agents.…”

Section: Discussionmentioning

confidence: 99%

“…Ibrahim et al reported a 66‐year‐old male patient with recurrence of low‐risk, localized sigmoid adenocarcinoma 2 months after the initiation of etanercept for the treatment of psoriasis and psoriatic arthritis. TNF‐α inhibitors may lead to tumor cell proliferation by preventing the activating role of TNF‐α in anti‐tumor immune response 20 . Colorectal cancer has also been reported as an adverse effect in psoriasis patients treated with ustekinumab 21 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Colonoscopy in patients with psoriasis before the initiation of treatment with biological agents

Tamer

Yüksel

2020

Dermatologic Therapy

View full text Add to dashboard Cite

Psoriasis may lead to subsequent colorectal cancer, since chronic systemic inflammation is the common etiologic factor in both psoriasis and colorectal cancer. It is a matter of dispute whether biological agents used in the treatment of psoriasis cause predisposition to colorectal cancer as a result of their immunosuppressive effect. Medical records of psoriasis patients who underwent colonoscopy before biological agents were reviewed. Colonoscopy was performed in all patients who were aged 50 years and older and in patients younger than 50, if they had positive fecal occult blood test results. The study included 95 patients between the age of 34 to 84. Colonoscopy results revealed tubular adenoma in 16 (16.8%) patients, hyperplastic polyps in 7 (7.4%) patients, villous adenoma in 1 (1.1%) patient, and tubulovillous adenoma in 1 (1.1%) patient. Two patients were diagnosed with colon cancer detected by a former colonoscopy, which was recommended by their dermatologist before the biological agent treatment plan. These results revealed that adenomatous polyps which can evolve to colon adenocarcinoma were the most frequent polyp type in patients with psoriasis. We suggest that routine colonoscopy should be performed before the initiation of biological therapy in psoriasis patients who are aged 50 years old and over.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%