Late Recurrence of Renal Cell Carcinoma: Retrospective and Collaborative Study of the Japanese Society of Renal Cancer

Miyao, Noriomi; Naito, Seiji; Ozono, Seiichiro; Shinohara, Nobuo; Masumori, Naoya; Igarashi, Tatsuo; Nakao, Masahiro; Tsushima, Tomoyasu; Sugita, Y.; Horie, Shigeo; Kanayama, Hiro‐omi; Tokuda, Noriaki; Kobayashi, Mikio

doi:10.1016/j.urology.2010.07.462

Cited by 88 publications

(81 citation statements)

References 15 publications

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“…The most common late recurrence sites were lung (n=16), and bone (n=6). Only four patients developed brain metastasis (8 A long disease free interval was considered to be a favorable prognostic factor in metastatic RCC (10). The overall survival was affected by the age at initial nephrectomy, not by late recurrence itself.…”

Section: Discussionmentioning

confidence: 98%

“…The biologic behavior of RCC is unique and different. The late recurrence is one of the specific entity with a rate of 10.5%-21.6% at 15 and 20 years respectively (8). Nakona et al revealed that two (4.3%) of 43 patients had late recurrence 10 years after nephrectomy (9).…”

Section: Discussionmentioning

confidence: 99%

“…Miyao N et al suggested that follow up of RCC ≥10 years after nephrectomy. Abdominal tomography or abdominal ultrasonography and pulmonary examination with chest x-ray or tomography should be recommended annually (8). For brain and bone metastases symptoms based follow up is important.…”

Section: Discussionmentioning

confidence: 99%

“…After an initial 5-year postoperative disease free interval the late recurrence rate was reported as 6-20% (8,13). The most recurrences were distant rather than local.…”

Section: Discussionmentioning

confidence: 99%

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Solitary Cerebral Metastases from Renal Cell Carcinoma 16 years After Nephrectomy

Gümüşay¹,

Benekli²,

Algın³

et al. 2014

Acta Oncol Tur.

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ÖZETTanıdan l0 yıl sonar gelişen local nüks ve uzak metastaz, renal hücreli kanserin (RCC) geç rekkürrensi olarak adlandırılır. Geç rekürrens %4.7-11 oranında görülmektedir. Bu olgu sunumunda RCC nedeniyle nefrektomi yapılan ve 16 yıl sonra soliter beyin metastazı gelişen 54 yaşındaki kadın hastayı tartışmayı amaçladık. İntrakranial tumor nedeni ile gross total eksizyon yapıldı. Patolojik tanısı RCC metastazı olarak saptandı. Yapılan immune histokimyasal incelemede beyin metastazı ile 16 yıl once yapılan nefrektomi patolojisinin aynı olduğu saptandı. Postoperatif hastaya gamma-knife uygulandı. Hastaya interferon başlandı. Erken evre RCC hastalarında da yıllık kontrollerin >10 yıl sonra da devam edilmesi ile nüksün erken saptanması ile cerrahi rezeksiyon şansı sağlayabilir. Gelecekte yapılan çalışmalarla, gerçekkürens gelişiminde rolalan risk faktörlerinin belirlenmesi uzun takip süresi gereken hastalaları belirleme de katkı sağlayacaktır. Anahtar Kelimeler: Geç Rekürrens; Renal Hücreli Kanser; Beyin Metastazı ABSTRACT Late recurrence of RCC was described as developing local recurrence or distant metastasis with a latency period of more than 10 years after nephrectomy. The rate of late recurrence after nephrectomy ranges from 4.7% to 11%. Here we report the case of a 54 year-old white female with RCC who developed brain metastasis 16 years after nephrectomy. Gross total resection of intracranial tumor was performed. Histologic examination and immunohistochemical profile of the primary renal tumor and metastatic cranial tumor showed identical morphology and immunophenotype. She was treated with gamma knife stereotactic radiosurgery. Postoperatively, the patient received interferon. Long term surveillance in RCC could be important for earlier detection of recurrence and provide chance for surgical resection. Future studies and long follow up are needed to identify risk factors for late recurrence in patients with RCC.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…After an initial 5-year postoperative disease free interval the late recurrence rate was reported as 6-20% (8,13). The most recurrences were distant rather than local.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Solitary Cerebral Metastases from Renal Cell Carcinoma 16 years After Nephrectomy

Gümüşay¹,

Benekli²,

Algın³

et al. 2014

Acta Oncol Tur.

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“…According to a previous study performed by Nakano et al (10) and Miyao et al (11), ~5% of patients who were disease-free for 10 years following nephrectomy developed late recurrence of RCC. Furthermore, Miyao et al (11) noted that lymph node metastasis was predictive of late recurrence. Conversely, lymph node metastasis was not observed in the present patient at the initial surgery.…”

mentioning

confidence: 96%

Recurrence of renal cell carcinoma diagnosed using contralateral adrenal biopsy with endoscopic ultrasound-guided fine-needle aspiration

Tanimoto

Takeuchi

Yaegashi

et al. 2016

Molecular and Clinical Oncology

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Abstract.A 76-year-old female in whom a renal cell carcinoma (RCC) lesion was resected 19 years previously presented to our hospital with cognitive dysfunction. Magnetic resonance imaging and computed tomography revealed nodules in the brain, lung, adrenal gland and a pelvic osteolytic lesion. To identify the primary cancer site, the present study performed endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the left adrenal lesion. Consequently, the pathological findings of the tissue obtained by EUS-FNA were similar to those of the previous nephrectomy specimen, revealing that the adrenal lesion was the recurrence of RCC. The majority of the metastatic lesions in the patient were reduced in size by the multiple kinase inhibitor, pazopanib. Contralateral adrenal metastasis of RCC is rare and the use of EUS-FNA in the diagnosis of adrenal lesions remains to be elucidated. This is a rare case of adrenal lesion, diagnosed by EUS-FNA. Therefore, EUS-FNA is considered to be a useful diagnostic modality of adrenal metastases from unidentified primary tumor types. IntroductionRenal cell carcinoma (RCC), which accounts for ~5% of all epithelial cancer types, is the ninth most common cancer worldwide. Around 20% of patients experience recurrence or develop metastatic RCC following nephrectomy (1). Although late recurrence of RCC following curative initial surgery is not a rare event, a previous study demonstrated that contralateral adrenal metastasis of RCC is rare (2). Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a relatively novel modality for obtaining samples from deep-seated lesions. In a previous study, adrenal gland samples obtained by EUS-FNA biopsy were adequate for determining a pathological diagnosis (3). The present study reported a rare case of contralateral adrenal metastasis of RCC, which was diagnosed by EUS-FNA. Case reportA 76-year-old female with a complaint of cognitive dysfunction visited the Department of Neurosurgery, Kanazawa University Hospital (Ishikawa, Japan). The patient was previously diagnosed with RCC of the right kidney in the Department of Urology, Public Central Hospital of Matto (Ishikawa, Japan) 19 years previously. The right kidney was removed and the patient received no adjuvant therapy at that time. A physical examination revealed no findings other than disorientation, and laboratory data, including tumor markers, revealed no notable findings. Brain gadolinium contrast-enhanced magnetic resonance imaging uncovered several nodules (Fig. 1), whereas chest and abdominal computed tomography (CT) identified a single nodule in the right lower lobe of the lungs, a mass in the left adrenal gland and an osteolytic lesion in the left pelvis (Data not shown). On the basis of these findings, the patient was diagnosed with a metastatic brain tumor. Following diagnosis, the patient received stereotactic radiosurgery with gamma knife therapy for the brain lesions. To identify the primary lesion, the present case study attempted to obtain histological confirmation...

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Role of clinicopathological variables in predicting recurrence and survival outcomes after surgery for non‐metastatic renal cell carcinoma: Systematic review and meta‐analysis

Majdoub,

Yanagisawa,

Quhal

et al. 2023

Intl Journal of Cancer

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Renal cell carcinoma (RCC) represents 2% of all diagnosed malignancies worldwide, with disease recurrence affecting 20% to 40% of patients. Existing prognostic recurrence models based on clinicopathological features continue to be a subject of controversy. In this meta‐analysis, we summarized research findings that explored the correlation between clinicopathological characteristics and post‐surgery survival outcomes in non‐metastatic RCC patients. Our analysis incorporates 99 publications spanning 140 568 patients. The study's main findings indicate that the following clinicopathological characteristics were associated with unfavorable survival outcomes: T stage, tumor grade, tumor size, lymph node involvement, tumor necrosis, sarcomatoid features, positive surgical margins (PSM), lymphovascular invasion (LVI), early recurrence, constitutional symptoms, poor performance status (PS), low hemoglobin level, high body‐mass index (BMI), diabetes mellitus (DM) and hypertension. All of which emerged as predictors for poor recurrence‐free survival (RFS) and cancer‐specific survival. Clear cell (CC) subtype, urinary collecting system invasion (UCSI), capsular penetration, perinephric fat invasion, renal vein invasion (RVI) and increased C‐reactive protein (CRP) were all associated with poor RFS. In contrast, age, sex, tumor laterality, nephrectomy type and approach had no impact on survival outcomes. As part of an additional analysis, we attempted to assess the association between these characteristics and late recurrences (relapses occurring more than 5 years after surgery). Nevertheless, we did not find any prediction capabilities for late disease recurrences among any of the features examined. Our findings highlight the prognostic significance of various clinicopathological characteristics potentially aiding in the identification of high‐risk RCC patients and enhancing the development of more precise prediction models.

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Late Recurrence of Renal Cell Carcinoma: Retrospective and Collaborative Study of the Japanese Society of Renal Cancer

Cited by 88 publications

References 15 publications

Solitary Cerebral Metastases from Renal Cell Carcinoma 16 years After Nephrectomy

Solitary Cerebral Metastases from Renal Cell Carcinoma 16 years After Nephrectomy

Recurrence of renal cell carcinoma diagnosed using contralateral adrenal biopsy with endoscopic ultrasound-guided fine-needle aspiration

Role of clinicopathological variables in predicting recurrence and survival outcomes after surgery for non‐metastatic renal cell carcinoma: Systematic review and meta‐analysis

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