“…However, oral examination alone is not sufficient for the detection and accurate distinction of benign, PMD, and malignant lesions. 19,20 Clinical screening followed by histopathological analysis is crucial, given the estimated annual number of new lip cancer cases worldwide and the wide range of lesions that occur in this location. 21,22 Biopsy, paired with clinical examination, is recommended for final diagnosis; in addition, this approach is recommended when lesions persist despite treatment or the removal of local irritants (of traumatic or inflammatory origin), when lesions do not recede in 2 weeks, when malignancy is suspected, and when lesions interfere with function or impair aesthetics.…”