f (Q, T) theory of gravity is very recently proposed to incorporate within the action Lagrangian, the trace T of the energy-momentum tensor along with the non-metricity scalar Q. The cosmological application of this theory in a spatially flat isotropic and homogeneous Universe is well-studied. However, our Universe is not isotropic since the Planck era and therefore to study a complete evolution of the Universe we must investigate the f (Q, T) theory in a model with a small anisotropy. This motivated us to presume a locally rotationally symmetric (LRS) Bianchi-I spacetime and derive the motion equations. We analyse the model candidate f (Q, T) = αQ n+1 + βT, and to constrain the parameter n, we employ the statistical Markov chain Monte Carlo (MCMC) method with the Bayesian approach using two independent observational datasets, namely, the Hubble datasets, and Type Ia supernovae (SNe Ia) datasets.