Late toxicity of image-guided hypofractionated radiotherapy for prostate: non-randomized comparison with conventional fractionation

Jereczek‐Fossa, Barbara Alicja; Surgo, A.; Maisonneuve, Patrick; Maucieri, A.; Gerardi, Marianna Alessandra; Zerini, Dario; Marvaso, Giulia; Ciardo, D.; Volpe, Stefania; Rojas, Damaris Patricia; Riva, Giulia; Alessandro, Ombretta; Dicuonzo, Samantha; Fanetti, Giuseppe; Romanelli, P.; Starzyńska, Anna; Cattani, Federica; Cambria, Raffaella; Fodor, C.; Garibaldi, Cristina; Romanò, Chiara; Cobelli, Ottavio De; Orecchia, Roberto

doi:10.1007/s11547-018-0937-9

Cited by 16 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RT is a common therapeutic choice in prostate cancer, it can be performed by external beam RT or brachytherapy [82][83][84][85]. RT may induce physiological changes that must be correctly interpreted given that they can hinder tumor detection as well as mimic tumor recurrence.…”

Section: Urinary and Prostatementioning

confidence: 99%

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

et al. 2021

View full text Add to dashboard Cite

Newer biologic drugs and immunomodulatory agents, as well as more tolerated and effective radiation therapy schemes, have reduced treatment toxicity in oncology patients. However, although imaging assessment of tumor response is adapting to atypical responses like tumor flare, expected changes and complications of chemo/radiotherapy are still routinely encountered in post-treatment imaging examinations. Radiologists must be aware of old and newer therapeutic options and related side effects or complications to avoid a misinterpretation of imaging findings. Further, advancements in oncology research have increased life expectancy of patients as well as the frequency of long-term therapy-related side effects that once could not be observed. This pictorial will help radiologists tasked to detect therapy-related complications and to differentiate expected changes of normal tissues from tumor relapse.

show abstract

Section: Urinary and Prostatementioning

confidence: 99%

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

et al. 2021

View full text Add to dashboard Cite

show abstract

“…After further exclusion, 26 articles were eligible for inclusion, but 6 of them were excluded due to the inappropriate form of outcomes [17] , [37] , [38] , [39] , [40] , [41] and 2 were excluded because of the same cohort of patients [42] , [43] . Ultimately, 18 studies that met the eligibility criteria were finally selected, including 3 RCTs, [19] , [23] , [44] 4 PCSs [45] , [46] , [47] , [48] and 11 RCSs [18] , [21] , [22] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] . A PRISMA flow diagram depicting the study identification and selection is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

The role of image-guided radiotherapy in prostate cancer: A systematic review and meta-analysis

Wang

Tang

Luo

et al. 2023

Clinical and Translational Radiation Oncology

View full text Add to dashboard Cite

“…The upper limit for the prescribed dose for DIL was considered 70 Gy in 27 fractions for high risk DILs. This hypofractionated dose escalation was used and evaluated in many studies (35)(36)(37)(38)(39)(40)(41)(42). According to a study by Onjukka et al (43), this hypofractionated dose was equivalent to 86 Gy in 37 sessions (used in the study of Uzan et al (44).…”

Section: Methodsmentioning

confidence: 99%

Introducing new plan evaluation indices for prostate dose painting IMRT plans based on apparent diffusion coefficient images

Moradi

Hashemi

Bakhshandeh

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Dose painting planning would be more complicated due to different levels of prescribed doses and more complex evaluation with conventional plan quality indices considering uniform dose prescription. Therefore, we tried to introduce new indices for evaluating the dose distribution conformity and homogeneity of treatment volumes based on the tumoral cell density and relative volumes of each lesion in prostate IMRT. Methods: CT and MRI scans of 20 male patients having local prostate cancer were used for IMRT DP planning. Apparent diffusion coefficient (ADC) images were imported to a MATLAB program to identify lesion regions based on ADC values automatically. Regions with ADC values lower than 750 mm2/s and regions with ADC values higher than 750 and less than 1500 mm2/s were considered CTV70Gy (clinical tumor volume with 70Gy prescribed dose), and CTV60Gy, respectively. Other regions of the prostate were considered as CTV53Gy. New plan evaluation indices based on evaluating the homogeneity (IOE(H)), and conformity (IOE(C)) were introduced, considering the relative volume of each lesion and cellular density obtained from ADC images. These indices were compared with conventional homogeneity and conformity indices and IOEs without considering cellular density. Furthermore, tumor control probability (TCP) was calculated for each patient, and the relationship of the assessed indices were evaluated with TCP values.Results: IOE (H) and IOE (C) with considering cellular density had significantly lower values compared to conventional indices and IOEs without considering cellular density. (P<0.05). TCP values had a stronger relationship with IOE(H) considering cell density (R2=-0.415), and IOE(C) without considering cell density (R2=0.624). Conclusion: IOE plan evaluation indices proposed in this study can be used for evaluating prostate IMRT dose painting plans. We suggested to consider cell densities in the IOE(H) calculation formula and it’s appropriate to calculate IOE(C) without considering cell density vaqlues.

show abstract

Late toxicity of image-guided hypofractionated radiotherapy for prostate: non-randomized comparison with conventional fractionation

Cited by 16 publications

References 25 publications

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

Imaging side effects and complications of chemotherapy and radiation therapy: a pictorial review from head to toe

The role of image-guided radiotherapy in prostate cancer: A systematic review and meta-analysis

Introducing new plan evaluation indices for prostate dose painting IMRT plans based on apparent diffusion coefficient images

Contact Info

Product

Resources

About