Latency of the Gastric Secretory Response to Sham Feeding in the Dog

Rm, Preshaw

doi:10.1139/y67-076

Cited by 2 publications

(1 citation statement)

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“…In the present study we failed to demonstrate significant inhibition in vagally innervated fundic pouches. This result confirms the findings in our previous investigation (Wheeler et al, 1973) and that reported by Preshaw (1967); consequently no support is provided for the existence of a neuronal inhibitory mechanism of antral origin active against pentagastrinstimulated acid secretion.…”

Section: Discussionsupporting

confidence: 88%

Antral acidification and the gastric secretory response to pentagastrin and acetylcholine in dogs

Wheeler

Prescott

Forrest

1974

Journal of British Surgery

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In 6 dogs with innervated antral pouches (3 with vagally innervated fundic pouches and 3 with vagally denervated fundic pouches) gastric secretion was stimulated by a range of submaximal doses of pentagastrin, each infused intravenously for a period of 6 hours. During the three consecutive 2‐hour collection periods of each test the antral pouch was perfused with isotonic saline of pH 7 0, 1.0 and 7.0 respectively at a rate of I ml/min. Neither acid nor pepsin secretion was inhibited by antral acidification. When the antral perfusion rate was increased to 3 ml/min there was still no inhibition of acid secretion from either type of fundic pouch. In each dog the acid response of the fundic pouch to perfusion of the innervated antral pouch with 0‐5 per cent acetylcholine was significantly reduced when the pH of the perfusate was lowered from 7.0 to 1.0. The results provide no support for the existence of either an antral inhibitory hormone or inhibitory neural reflex active against pentagastrin‐stimulated gastric secretion in the dog. It would seem that antral inhibition of gastric secretion is the result of a diminished release or formation of endogenous gastrin.

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Section: Discussionsupporting

confidence: 88%