Latent 1,3-β-D-glucan acts as an adjuvant for allergen-specific IgE production induced by Japanese cedar pollen exposure

Kanno, Takashi; Adachi, Yoshiyuki; Ohashi-Doi, Katsuyo; Matsuhara, Hiroki; Hiratsuka, Rie; Ishibashi, Keiichiro; Yamanaka, Daisuke; Ohno, Naohito

doi:10.1016/j.alit.2020.08.004

Cited by 9 publications

(5 citation statements)

References 46 publications

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Section: Discussionmentioning

confidence: 99%

“…Recently, Kanno et al [ 46 ] reported that β-D-glucan in JCP acts as an immunological adjuvant for allergic inflammation, and may be associated with exacerbated sneezing in a mouse model. β-D-glucan was detected in the exine and cell wall of the generative cell and tube cell of the grain of JCP [ 46 ]. In that study, β-D-glucan in the exine stimulated the production of tumor necrosis factor α and IL-6 in bone marrow-derived dendritic cells through dectin-1 [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…β-D-glucan was detected in the exine and cell wall of the generative cell and tube cell of the grain of JCP [ 46 ]. In that study, β-D-glucan in the exine stimulated the production of tumor necrosis factor α and IL-6 in bone marrow-derived dendritic cells through dectin-1 [ 46 ]. As for eosinophils, the expression of dectin-1 remains controversial [ 12 47 48 ].…”

Section: Discussionmentioning

confidence: 99%

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Japanese cedar pollen upregulates the effector functions of eosinophils

Miyauchi

Nakagome

Noguchi

et al. 2021

Asia Pacific Allergy

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Background Symptoms of rhinitis and asthma can be exacerbated during Japanese cedar pollen (JCP)-scattering season, even in subjects who are not sensitized to JCP, suggesting that innate immune responses may contribute to this process. We previously reported that house dust mite directly activates the effector functions of eosinophils. Similar mechanisms may play roles in the JCP-related aggravation of allergic diseases. Objective To investigate whether JCP or Cry j 1, a major allergen of JCP, can modify the effector functions of eosinophils. Methods Eosinophils isolated from the peripheral blood of healthy donors were stimulated with either JCP or Cry j 1, and their adhesion to human intercellular adhesion molecule-1 was measured using eosinophil peroxidase assays. The generation of eosinophil superoxide anion (O 2 − ) was measured based on the superoxide dismutase-inhibitable reduction of cytochrome C. Concentrations of eosinophil-derived neurotoxin in the cell media were measured by enzyme-linked immunosorbent assay as a marker of degranulation. Results Both JCP and Cry j 1 directly induced eosinophil adhesiveness, generation of O 2 − , and release of eosinophil-derived neurotoxin. Both anti-αM and anti-β2 integrin antibodies blocked all of these eosinophil functions induced by JCP and Cry j 1. Similarly, PAR-2 antagonists also partially suppressed all of these effector functions induced by JCP and Cry j 1. Conclusion JCP and Cry j 1 directly activate the functions of eosinophils, and both αMβ2 integrin and partly PAR-2 are contributed to this activation. Therefore, JCP-induced eosinophil activation may play a role in the aggravation of allergic airway diseases in nonsensitized patients as well as in JCP-sensitized patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Japanese cedar pollen upregulates the effector functions of eosinophils

Miyauchi

Nakagome

Noguchi

et al. 2021

Asia Pacific Allergy

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“…The potential of glucans for allergen-specific immunotherapy is still controversial. Some researchers demonstrated b-(1,3)-glucans, which can be found in either HDM feces or pollen grains derived from several plant species, to exacerbate allergic inflammation by activating DCs in vitro and enhancing allergen-specific IgE antibody as well as Th2 cytokine production in vivo (120,121). However, in another in vivo OVA-based food allergy mouse model, the authors applied either the low-molecular-weight b-(1,3)or a 50-80% branched b-(1,6)-glucan (purified from Aureobasidium pullulans).…”

Section: Glucansmentioning

confidence: 99%

Novel adjuvants in allergen-specific immunotherapy: where do we stand?

Lin,

Zimmermann,

Schülke

2024

Front. Immunol.

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Type I hypersensitivity, or so-called type I allergy, is caused by Th2-mediated immune responses directed against otherwise harmless environmental antigens. Currently, allergen-specific immunotherapy (AIT) is the only disease-modifying treatment with the potential to re-establish clinical tolerance towards the corresponding allergen(s). However, conventional AIT has certain drawbacks, including long treatment durations, the risk of inducing allergic side effects, and the fact that allergens by themselves have a rather low immunogenicity. To improve AIT, adjuvants can be a powerful tool not only to increase the immunogenicity of co-applied allergens but also to induce the desired immune activation, such as promoting allergen-specific Th1- or regulatory responses. This review summarizes the knowledge on adjuvants currently approved for use in human AIT: aluminum hydroxide, calcium phosphate, microcrystalline tyrosine, and MPLA, as well as novel adjuvants that have been studied in recent years: oil-in-water emulsions, virus-like particles, viral components, carbohydrate-based adjuvants (QS-21, glucans, and mannan) and TLR-ligands (flagellin and CpG-ODN). The investigated adjuvants show distinct properties, such as prolonging allergen release at the injection site, inducing allergen-specific IgG production while also reducing IgE levels, as well as promoting differentiation and activation of different immune cells. In the future, better understanding of the immunological mechanisms underlying the effects of these adjuvants in clinical settings may help us to improve AIT.

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“…2 ). Similarly, dectin-1 signaling has been proven to be essential for the development of Japanese cedar pollen–induced allergic rhinitis in mice [ 30 ] and participates in lung inflammation in a murine model of fungal allergy through the induction of IL-22 [ 31 ]. By contrast, it has been demonstrated that invertebrate tropomyosin (for example, Der p 10 in HDM) binds to dectin-1 at the mucosal surfaces and mediates protection against allergic diseases [ 32 ].…”

Section: The Role Of Clr In the Context Of Allergic Diseasesmentioning

confidence: 99%

C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens

Angelina

Martín-Cruz

Rocha-Muñoz

et al. 2023

Curr Allergy Asthma Rep

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Purpose of Review Allergic diseases represent a major health problem of increasing prevalence worldwide. In allergy, dendritic cells (DCs) contribute to both the pathophysiology and the induction of healthy immune responses to the allergens. Different studies have reported that some common allergens contain glycans in their structure. C-type lectin receptors (CLRs) expressed by DCs recognize carbohydrate structures and are crucial in allergen uptake, presentation, and polarization of T cell responses. This review summarizes the recent literature regarding the role of CLRs in the regulation of type 2 immune responses to allergens. Recent Findings In this review, we highlight the capacity of CLRs to recognize carbohydrates in common allergens triggering different signaling pathways involved in the polarization of CD4+ T cells towards specific Th2 responses. Under certain conditions, specific CLRs could also promote tolerogenic responses to allergens, which might well be exploited to develop novel therapeutic approaches of allergen-specific immunotherapy (AIT), the single treatment with potential disease-modifying capacity for allergic disease. At this regard, polymerized allergens conjugated to non-oxidized mannan (allergoid-mannan conjugated) are next-generation vaccines targeting DCs via CLRs that promote regulatory T cells, thus favoring allergen tolerance both in preclinical models and clinical trials. Summary A better understanding of the role of CLRs in the development of allergy and in the induction of allergen tolerance might well pave the way for the design of novel strategies for allergic diseases.

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Latent 1,3-β-D-glucan acts as an adjuvant for allergen-specific IgE production induced by Japanese cedar pollen exposure

Cited by 9 publications

References 46 publications

Japanese cedar pollen upregulates the effector functions of eosinophils

Japanese cedar pollen upregulates the effector functions of eosinophils

Novel adjuvants in allergen-specific immunotherapy: where do we stand?

C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens

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