Latent autoimmune diabetes in adults in China

Abstract

Latent autoimmune diabetes in adults (LADA) is a type of diabetes caused by slow progression of autoimmune damage to pancreatic beta cells. According to the etiological classification, LADA should belong to the autoimmune subtype of type 1 diabetes (T1D). Previous studies have found general immune genetic effects associated with LADA, but there are also some racial differences. Multicenter studies have been conducted in different countries worldwide, but it is still unclear how the Chinese and Caucasian populations differ. The epidemiology and phenotypic characteristics of LADA may vary between Caucasian and Chinese diabetic patients as lifestyle, food habits, and body mass index differ between these two populations. The prevalence of LADA in China has reached a high level compared to other countries. The prevalence of LADA in China has reached a high level compared to other countries, and the number of patients with LADA ranks first in the world. Previous studies have found general immune genetic effects associated with LADA, but some racial differences also exist. The prevalence of LADA among newly diagnosed type 2 diabetes patients over the age of 30 years in China is 5.9%, and LADA patients account for 65% of the newly diagnosed T1D patients in the country. As a country with a large population, China has many people with LADA. A summary and analysis of these studies will enhance further understanding of LADA in China. In addition, comparing the similarities and differences between the Chinese and the Caucasian population from the perspectives of epidemiology, clinical, immunology and genetics will help to improve the understanding of LADA, and then promote LADA studies in individual populations.

Relationship between β-Cell Autoantibodies and Their Combination with Anthropometric and Metabolic Components and Microvascular Complications in Latent Autoimmune Diabetes in Adults

“…In a clinical setting, it is essential to differentiate these two clinical phenotypes within the adult patient population because the prevalence of LADA has reached a high level in some countries. Nowadays, there is an increased prevalence of LADA in up to 5.9% of newly diagnosed patients with type 2 diabetes over the age of 30 and in almost 65% of patients with newly diagnosed T1DM in China [ 30 ].…”

A study on the mechanism of action of YiQiYangYin decoction for the treatment of diabetes based on network pharmacology

“…Diabetes mellitus (DM) is the most common metabolic disease of the endocrine system and is mostly seen in middle-aged and elderly people. China has the largest number of diabetic patients in the world (1). According to the data of the International Diabetes Federation in 2013, the total number of diabetic patients aged 20-79 years was 382 million worldwide, accounting for 8.3% of the total population in this age group, of which China accounts for 98 million, and it is estimated that the number will increase to 143 million in 2035 (2)(3)(4).…”