Latent Autoimmune Diabetes in Adults

Brooks-Worrell, Barbara; Palmer, Jerry P.

doi:10.1007/978-1-60327-478-4_19

Cited by 2 publications

(4 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All participants have signed an informed consent. Patients with LADA were enrolled if medical history included all of the following criteria: (1) onset at the age of 35 years or over; (2) presence of positive diabetes-associated autoantibodies, such as islet-cell cytoplasm autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GAD65A) ( 41 ), insulinoma-associated-2 antibodies – tyrosine phosphatase-associated (IA-2A) ( 42 ), zinc transporter 8 autoantibodies (ZnT8A) ( 43 ); (3) no need for insulin treatment for at least 6 months after diagnosis ( 39 ). All participants were assayed for GAD65A within the study as well ( Supplementary Table 1 , see section on supplementary data given at the end of this article).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

Zaharieva¹,

Kamenov²,

Velikova

et al. 2018

Endocrine Connections

View full text Add to dashboard Cite

BackgroundInterleukin-18 (IL-18) is an inflammatory cytokine found to be elevated in obesity, metabolic syndrome and type 2 diabetes (T2D) as a part of the chronic low-grade inflammatory process in these states. The aim of the study was to evaluate the interleukin level in patients with latent autoimmune diabetes of the adults (LADA) in comparison to that in T2D subjects.Materials and methodsIL-18 was analyzed through enzyme-linked immunosorbent assay in 76 participants with T2D and 24 with LADA and 14 control subjects. Evaluation was also carried out in body mass index (BMI)- and glycemic control-matched diabetic patients.ResultsThe serum concentration of IL-18 was higher in patients with T2D (389.04 ± 203.44 pg/mL) and LADA (327.04 ± 144.48 pg/mL) than that in control subjects (219.88 ± 91.03 pg/mL), P < 0.05. However, it was not significantly different between both diabetic groups (P = 0.255) despite higher IL-6 (4.78 ± 5.84 vs 1.79 ± 0.96 pg/mL, P < 0.001) and hs-CRP (2.60 ± 1.70 vs 1.29 ± 1.20 mg/L, P = 0.002) level in T2D patients. The results were persistent in BMI-matched subjects with diabetes (IL-18 = 403.48 ± 226.32 vs 329.30 ± 146.30 pg/mL, respectively for T2D and LADA, P = 0.391). The correlations in T2D group concerning HDL cholesterol (r = −0.377, P = 0.001), postprandial glucose (r = 0.244, P = 0.043), IL-6 (r = 0.398, P < 0.001) and hs-CRP (r = 0.427, P = 0.001) were not confirmed in LADA and control subjects.ConclusionThe IL-18 serum level was higher in T2D and LADA than that in control subjects, but did not differ between both diabetic groups, even when they were BMI matched. Correlations with lipid, glycemic and inflammatory parameters were present in T2D only.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The aim of the current study was to compare the serum level of IL-18 between patients with T2D and subjects who meet the criteria for LADA ( 39 ) and to estimate its association with weight, glycemic and lipid control, as well as that of the inflammatory markers IL-6 and hs-CRP within both groups.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

Zaharieva¹,

Kamenov²,

Velikova

et al. 2018

Endocrine Connections

View full text Add to dashboard Cite

show abstract

“…Inclusion criteria were age between 35 and 65 years, T2D diagnosed according to the criteria of the American Diabetes Association [ 19 ]. Patients with LADA were included if they meet the following three criteria: (1) onset at the age of 35 or more; (2) presence of positive diabetes-associated autoantibodies; and (3) history of satisfying glycemic control without insulin treatment for at least 6 months after diagnosis [ 5 ]. The control group included clinically healthy volunteers with BMI < 30 kg/m 2 .…”

Section: Methodsmentioning

confidence: 99%

“…This type of diabetes has been variously described as latent autoimmune diabetes in adults (LADA), diabetes type 1.5, autoimmune diabetes in adults with slowly progressive β -cell failure, and so forth [ 1 – 3 ]. Although questioned repeatedly [ 4 ], current criteria for the diagnosis of LADA remain age at the onset, the presence of positive diabetes-associated autoantibodies—islet-cell cytoplasm autoantibodies (ICA), glutamic acid decarboxylase autoantibodies (GAD65A), insulinoma-associated-2 antibodies—tyrosine phosphatase associated (IA-2A), zinc transporter 8 autoantibodies (ZnT8A); and satisfying glycemic control without insulin treatment for at least 6 months after diagnosis [ 5 – 8 ]. Frequency of positive autoantibodies among patients initially diagnosed with T2D varies between 4 and 14% [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population

Zaharieva

Velikova

Tsakova

et al. 2017

Journal of Diabetes Research

View full text Add to dashboard Cite

Background The study aimed to estimate the prevalence of unrecognized cases with positive autoantibodies among type 2 diabetes (T2D) in a sample of the Bulgarian population and to compare some metabolic and inflammatory markers to those of patients having negative autoantibodies and subjects with latent autoimmune diabetes (LADA). Methods Patients with T2D, patients with LADA, and control participants were enrolled. Antiglutamic acid decarboxylase, anti-insulinoma-associated 2, and antizinc transporter 8 autoantibodies were assayed through ELISA. C-reactive protein and interleukin 6 (IL-6) and tumor necrosis factor alpha were assessed. Results Ten percent of patients with T2D had positive autoantibodies. They had lower body mass index (p = 0.014), worse glycemic control (HbA1c, p = 0.033), and better HDL cholesterol (p = 0.026) than those in negative autoantibodies cases. Compared to LADA, glycemia and anthropometric data did not differ significantly but metabolic syndrome was more prevalent among newly found cases with positive autoantibodies (p = 0.046). Their level of inflammatory markers was similar to that of patients having negative autoantibodies (p > 0.05), but IL-6 was higher when compared to LADA (p = 0.002). Conclusion Prevalence of patients having positive autoantibodies within T2D in the analyzed sample of the Bulgarian population was 10%. They shared common metabolic features with subjects with LADA, but inflammatory phenotype was closer to that of T2D.

show abstract

Latent Autoimmune Diabetes in Adults

Cited by 2 publications

References 81 publications

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

Interleukin-18 serum level is elevated in type 2 diabetes and latent autoimmune diabetes

Prevalence of Positive Diabetes-Associated Autoantibodies among Type 2 Diabetes and Related Metabolic and Inflammatory Differences in a Sample of the Bulgarian Population

Contact Info

Product

Resources

About