Latent autoimmune diabetes in the young

New-Onset Diabetes in Obese Adolescents ? Type 1 or Type 2 Diabetes? Comparative Cases Report

“…If such a situation occurs, he will be diagnosed as LADY characterized by the slow progression of β-cell dysfunction [29]. Such a case report was presented by Zachariah et al, who demonstrated that autoimmune diabetes can be slowly progressive even in younger patients with insulin independency period lasting for more than two years [30]. Conversely, our female patient rather seems to have T1DM, with high titers of autoantibodies and lower endogenous insulin production.…”

Standard mortality rates and years of life lost for serologically defined adult-onset type 1 and type 2 diabetes – A fifteen year follow-up

“…One might argue that while about 50% of our patients were classical onset type 1 patients, about 50% of the autoimmune patients in our cohort were in fact LADA (Latent Autoimmune Diabetes in Adults) patients, were some might have a better prognosis, but this was not the case in the few reports of prognosis in LADA that exist [31][32][33][34]. The problem however, is that the definition of LADA is not exact, some use age as a criteria, but this has been demonstrated to be unsatisfactory, as has time to need of insulin treatment [35,36]. The World Health Organization (WHO) and the American Diabetes Association (ADA) categorize LADA as a subgroup of type 1 diabetes [37].…”

Slowly evolving, immune-mediated diabetes in 14-year-old patient: a case report

“…Учитывая подобное сочетание особенностей диабета 1 и 2 типов, при постановке диагноза LADA руководствуются следующими критериями: наличие антител к GAD, возраст более 35 лет и отсутствие потребности в инсулине в течение 6-12 мес от момента выявления диабета. И в самом названии «латентный аутоиммунный диабет взрослых», и в критериях постановки диагноза делается акцент на возраст больного -более 35 лет, однако симптомы LADA отмечаются и у пациентов более молодого возраста: в частности, описаны случаи заболевания у детей 8-15 лет [15][16][17][18]. Аналогично LADA, данный тип сахарного диабета был назван «латентный аутоиммунный диабет молодых» (Latent Autoimmune Diabetes in the Young, LADY), что отражает типичный возраст дебюта заболевания и схожую с LADA клиническую картину [18,19].…”