Latent Characteristics and Neural Manifold of Brain Functional Network Under Acupuncture

Abstract

Acupuncture can regulate the cognition of brain system, and different manipulations are the keys of realizing the curative effect of acupuncture on human body. Therefore, it is crucial to distinguish and monitor the different acupuncture manipulations automatically. In this brief, in order to enhance the robustness of electroencephalogram (EEG) detection against noise and interference, we propose an acupuncture manipulation detecting framework based on supervised ISOMAP and recurrent neural network (RNN). Primarily, the low-dimensional embedding neural manifold of brain dynamical functional network is extracted via the reconstructed geodetic distance. It is found that there exhibits stronger acupuncture-specific reconfiguration of brain network. Besides, we show that the distance travel along this manifold correlates strongly with changes of acupuncture manipulations. The low-dimensional brain topological structure of all subjects shows crescent-like feature when acupuncturing at Zusanli acupoints, and fixedpoints are varying under diverse manipulation methods. Moreover, Takagi-Sugeno-Kang (TSK) classifier is adopted to identify acupuncture manipulations according to the nonlinear characteristics of neural manifolds. Compared with different classifier, TSK can further improve the accuracy of manipulation identification at 96.71%. The results demonstrate the effectiveness of our model in detecting the acupuncture manipulations, which may provide neural biomarkers for acupuncture physicians.

Global trends and hotspots in research on acupuncture for stroke: a bibliometric and visualization analysis

“…The intersection of acupuncture combined with neuroscience and computational science will be an important development in acupuncture for stroke. Several studies [ 74 – 76 ] have shown that integrating complex central nerves may be the key to acupuncture. Network neuroscience and traditional functional connectivity computing rely on a node-centric network model.…”

Neural Mechanism and Effect of Acupuncture for Central Nervous System Diseases

“…Acupuncture is a common non-pharmacological treatment for improving gastrointestinal and neurological symptoms (Kwon et al, 2021;Fan et al, 2022a;Yao et al, 2022). Studies have shown that acupuncture can improve gastrointestinal and neurological symptoms while also relieving emotional symptoms (Wang et al, 2022a;Ying-Jia Li et al, 2022). However, it has also been questioned if this is a result of the placebo effects of acupuncture.…”

Neural Mechanism and Effect of Acupuncture for Central Nervous System Diseases

“…Acupuncture is a common non-pharmacological treatment for improving gastrointestinal and neurological symptoms (Kwon et al, 2021;Fan et al, 2022a;Yao et al, 2022). Studies have shown that acupuncture can improve gastrointestinal and neurological symptoms while also relieving emotional symptoms (Wang et al, 2022a;Ying-Jia Li et al, 2022). However, it has also been questioned if this is a result of the placebo effects of acupuncture.…”