Objective
The purpose of this study is to examine the association between verbal learning, fluency, and processing speed with anxious-depression symptomatology among diverse Hispanic/Latinos. We hypothesize an inverse association of anxious-depression with neurocognition among Hispanic/Latinos of different heritage.
Design
Data are from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The sample included 9,311participants aged 45–74 years (Mean:56.6). A latent class analysis of items from the Center for Epidemiological Studies for Depression (CESD-10 item) and the Spielberger State-Trait Anxiety Inventory was used to derive an anxious-depression construct. Neurocognitive measures included scores on the Brief Spanish English Verbal Learning Test (B-SEVLT learning and recall trials), Word Fluency (WF), Digit Symbol Substitution (DSS) test and a Global Cognitive Score (GCS). We fit survey linear regression models to test the associations between anxious-depression symptomatology and cognitive function.
Results
Among men, 71% reported low, 24% moderate, and 5% high ADS. Among women, 54.7% reported low, 33.2% moderate, and 12.2% high ADS. After controlling for age, sex, weight, socio-demographic characteristics, cardiovascular risk factors, and antidepressant use, we found significant inverse associations between moderate and high anxious-depression (ref:low) with B-SEVLT learning and recall, DSST and GCS (p-values≤0.05). Moderate, but not high, anxious-depression was inversely associated with WF (p-value<0.05).
Conclusion
Increased anxious-depression symptomatology is associated with decreased neurocognitive function among Hispanic/Latinos. Longitudinal studies are needed to establish temporality and infer if negative emotional symptoms precede cognitive deficits.