Latent Profile Analysis of Neuropsychiatric Symptoms and Cognitive Function of Adults 2 Weeks After Traumatic Brain Injury

Abstract

Key Points Question Are distinct phenotypes of neurobehavioral function identifiable 2 weeks after traumatic brain injury (TBI), and are phenotypes associated with 6-month quality of life and daily functioning? Findings In this cohort study of 1757 patients with TBI, 4 distinct neurobehavioral phenotypes were identified 2 weeks after injury based on self-report and cognitive performance measures. Phenotypes were associated with improved estimations of 6-month outcomes compared with conventional medical record documentation and injury severity factors. Meaning These findings suggest that a phenotype-based classification system could potentially be used as part of an applied precision medicine approach to reliably identify patients at risk for poor outcomes and in need of early, targeted intervention based on phenotypic characteristics following TBI.

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