Latent profiles of impulsivity facets and associations with drinking behaviors

Stamates, Amy L.; Schulz, Christina T.; Ehlke, Sarah; Thompson, Lauren; Lau‐Barraco, Cathy; Kelley, Michelle L.

doi:10.1016/j.drugalcdep.2021.108979

Cited by 7 publications

(3 citation statements)

References 49 publications

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“…Findings are somewhat in line with Rogers et al (2021), as we found similar profiles characterized by either higher sensation seeking and urgency or higher (lack of) premeditation/perseverance was supported. Further, we found two profiles, a low and moderate impulsivity, that were consistent with findings from Stamates et al (2021), The high sensation seeking/urgency profile was more likely to engage in SAM use relative to the low or moderate impulsivity profile. This finding is critical as individuals who endorse SAM use may be particularly vulnerable for reward- or emotion-based impulsivity, which may heighten their risk for hazardous use (Stamates & Lau-Barraco, 2017) as well as other additional nonsubstance use types of externalizing psychopathology (Carver & Johnson, 2018).…”

Section: Discussionsupporting

confidence: 85%

“…Rogers et al (2021) found a five-class solution, whereby the high lack of premeditation and perseverance profile reported the highest level of alcohol use (Rogers et al, 2021). Stamates et al (2021) revealed a three-class solution with the profile endorsing highest levels across all facets indicating the most alcohol-related consequences (Stamates et al, 2021). However, this research has not been extended to SAM use.…”

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confidence: 99%

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Impulsivity typologies and simultaneous alcohol and cannabis use.

Stamates¹,

Linden-Carmichael²,

Miller³

et al. 2023

Experimental and Clinical Psychopharmacology

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Simultaneous use of alcohol and cannabis or marijuana (“SAM”) use is prevalent among young adults and associated with adverse outcomes. Impulsivity is a key construct associated with alcohol and other substance use in this age group, but scant work has considered the role of individual facets of impulsivity on SAM use. The present study compared latent profiles defined by facets of impulsivity (negative urgency, lack of perseverance, lack of premeditation, sensation seeking, and positive urgency) and examined whether profiles were associated with recent SAM use relative to alcohol without cannabis use. Participants were 542 young adults (53% female) recruited through Qualtrics Panels who reported past-year alcohol use and blackout drinking behavior. Participants completed online questionnaires regarding their past-year substance use behavior and typical impulsivity. Regression analysis examining the five impulsivity facets revealed that only sensation seeking predicted the likelihood of recent SAM use relative to alcohol without cannabis use. Using latent profile analysis, four profiles were identified: “low impulsivity,” “high sensation seeking/urgency impulsivity,” “moderate impulsivity,” and “high lack of premeditation/perseverance impulsivity.” Individuals in the high sensation seeking/urgency group were more likely to engage in SAM use. Impulsivity may be an important individual difference factor associated with SAM use. Young adults who engage in SAM use may be particularly vulnerable for impulsivity related to sensation seeking and urgency, which may further heighten their risk for hazardous use and related outcomes.

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Section: Discussionsupporting

confidence: 85%

mentioning

confidence: 99%

Impulsivity typologies and simultaneous alcohol and cannabis use.

Stamates¹,

Linden-Carmichael²,

Miller³

et al. 2023

Experimental and Clinical Psychopharmacology

Self Cite

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“…Stamates et al. found that individuals with high levels of impulsivity appear to have more significant negative internal and external motives for drinking ( 41 ). Moreover, high trait impulsivity, as measured with the BIS-11, may result in/from heavy drinking patterns in young social drinkers ( 42 ).…”

Section: Discussionmentioning

confidence: 99%

The effects of BDNF rs6265 and FGF21 rs11665896 polymorphisms on alcohol use disorder-related impulsivity in Han Chinese adults

Yang,

Wang,

Sun

et al. 2024

Front. Psychiatry

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IntroductionPatients with alcohol use disorder (AUD) often experience repeated withdrawal. Impulsivity is the most relevant factor influencing successful withdrawal. Brain-derived neurotrophic factor (BNDF) and fibroblast growth factor 21 (FGF21) are associated with impulsivity. Previous studies on the differential effects of BDNF or FGF21 on impulsivity have focused on single-gene effects and have inconsistent results. We aim to investigate the effects of BDNF rs6265 and FGF21 rs11665896, individually and together, on impulsivity during alcohol withdrawal in patients with AUD.MethodsWe recruited 482 adult Han Chinese males with AUD and assessed their impulsivity using the Barratt Impulsivity Scale. Genomic DNA was extracted and genotyped from peripheral blood samples. Statistical analysis was conducted on the data.ResultsThe T-test and 2 × 2 analysis of variance were used to investigate the effects of the genes on impulsivity. There was a significant BDNF × FGF21 interaction on no-planning impulsiveness (F = 9.15, p = 0.003, η2p = 0.03). Simple main effects analyses and planned comparisons showed that BDNF rs6265 A allele × FGF21 rs11665896 T allele was associated with higher no-planning impulsiveness. Finally, hierarchical regression analyses revealed that only the interaction of BDNF and FGF21 accounted for a significant portion of the variance in no-planning impulsiveness.Conclusion and significanceThe combination of BDNF rs6265 A allele and FGF21 rs11665896 T allele may increase impulsivity and discourage alcohol withdrawal. Our study provides a possible genetic explanation for the effects of associated impulsivity in patients with AUD from the perspective of gene-gene interactions.

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