Latent (slowly progressing) autoimmune diabetes in adults

Seißler, Jochen

doi:10.1007/s11892-008-0018-x

Cited by 20 publications

(8 citation statements)

References 52 publications

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“…No treatment guidelines for LADA have been published; therefore patients are mostly treated as affected by type 2 diabetes [ 3 ]. Most patients are treated with diet and oral hypoglycemic agents until the secondary failure to treatment with oral hypoglycemic agents results in the need to switch to insulin therapy [ 12 ]. Approximately 25% of LADA patients have serological evidence of autoimmune thyroiditis, but there are no reports on the frequency of clinical thyroid disease [ 10 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult

Nadhem

Nakhla

Smalligan

2015

Case Reports in Medicine

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A 54-year-old white female with hypothyroidism presented with abdominal pain, nausea, vomiting, and diarrhea. She was found to have diabetic ketoacidosis (DKA) and admitted to our hospital for treatment. Laboratory workup revealed positive antiglutamic acid decarboxylase antibodies and subsequently she was diagnosed with latent onset autoimmune diabetes in adult (LADA). She was successfully treated with insulin with clinical and laboratory improvement. Diagnosis of LADA has been based on three criteria as given by The Immunology of Diabetes Society: (1) adult age of onset (>30 years of age); (2) presence of at least one circulating autoantibody (GADA/ICA/IAA/IA-2); and (3) initial insulin independence for the first six months. The importance of this case is the unlikely presentation of LADA. We believe that more research is needed to determine the exact proportion of LADA patients who first present with DKA, since similar cases have only been seen in case reports. Adult patients who are obese and have high blood sugar may deserve screening for LADA, especially in the presence of other autoimmune diseases. Those patients once diagnosed with LADA need extensive diabetic education including potentially serious events such as diabetic ketoacidosis.

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Section: Discussionmentioning

confidence: 99%

Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult

Nadhem

Nakhla

Smalligan

2015

Case Reports in Medicine

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“…Latent Autoimmune Diabetes of Adults (LADA) is a form of adult autoimmune-mediated diabetes that phenotypically and genetically is intermediate between T1DM and T2DM [16,17]. Its diagnostic criteria are still controversial.…”

Section: Latent Autoimmune Diabetes Of Adultsmentioning

confidence: 99%

Diabetes Mellitus Type 1, Latent Autoimmune Diabetes of Adults and Hepatitis C Virus: What we Know and what we Need to Know

Maraolo¹

2013

J Diabetes Metab

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Hepatitis C virus infection and diabetes mellitus are two major public health problems worldwide and the burden\ud of these diseases is expected to increase in the near future. Hepatitis C virus is associated to autoimmune disorders\ud of several organs (e.g. thyroid and kidney) and has recently been reported to be associated also to metabolic\ud disorders including type 2 diabetes mellitus. Biologically, the homologies between the hepatitis C virus polyprotein\ud and the pancreas antigens could underlie a mechanism of molecular mimicry that could lead to autoimmune diabetes\ud (type 1 diabetes mellitus and latent autoimmune diabetes of adults). Here we review the data on the potential\ud relationship between HCV-related chronic liver disease and autoimmune mediated diabetes mellitus

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“…LADA should be diagnosed by the internists on the bariatric team by the presence of low plasma insulin, very low fasting and meal-stimulated C-peptide, and antibodies to glutamic acid decarboxylate, insulin, and/or islet cells [25][26][27][28][29][30]. These patients may initially respond to oral antidiabetic medication or GLP-1 while there are still 20% of the beta cells functioning, but will progress to insulindependent diabetes.…”

Section: Adult-onset Diabetes Typementioning

confidence: 99%

Update: Why Diabetes Does Not Resolve in Some Patients after Bariatric Surgery

Deitel

2010

OBES SURG

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Bariatric surgery provides resolution of co-morbidities of morbid obesity-importantly diabetes type 2. This is initiated by immediate postoperative decrease in intake or assimilation of glucose and is continued by the substantial loss of adipose tissue. Greater weight loss and greater resolution of type 2 diabetes occur after operations that provide rapid passage of nutrients to the hindgut, which likely results in beta-cell stimulation by incretins. Failure of resolution of the diabetes can result from lack of patient compliance, inadequate weight loss, longstanding uncontrolled diabetes, or when the diabetes is actually a type 1.

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Latent (slowly progressing) autoimmune diabetes in adults

Cited by 20 publications

References 52 publications

Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult

Diabetic Ketoacidosis as First Presentation of Latent Autoimmune Diabetes in Adult

Diabetes Mellitus Type 1, Latent Autoimmune Diabetes of Adults and Hepatitis C Virus: What we Know and what we Need to Know

Update: Why Diabetes Does Not Resolve in Some Patients after Bariatric Surgery

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