Latent tuberculosis infection screening in persons newly-diagnosed with HIV infection in Italy: A multicentre study promoted by the Italian Society of Infectious and Tropical Diseases

Goletti, Delia; Navarra, Assunta; Petruccioli, Elisa; Cimaglia, Claudia; Compagno, Mirko; Cuzzi, Gilda; Carli, Gabriella De; Fondaco, Laura; Franzetti, Fabio; Giannetti, Alberto; Gori, Andrea; Lapadula, Giuseppe; Lichtner, Miriam; Mastroianni, Claudio Maria; Mazzotta, Valentina; Orchi, Nicoletta; Pavone, Paolo; Piacentini, Daniela; Pirriatore, Veronica; Pontali, Emanuele; Sarmati, Loredana; Spolti, Anna; Tacconelli, Evelina; Galli, Massimo; Antinori, Andrea; Calcagno, Andrea; Girardi, Enrico

doi:10.1016/j.ijid.2019.12.031

Cited by 16 publications

(18 citation statements)

References 28 publications

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“…These result also in accordance with other results in other developing countries showing under than 20% HIV-TB coinfection cases [12], [13]. While, those HIV-TB cases in developed countries showed < 10% [14]. Thus, these results confirm the necessity to conduct screening for early detection of HIV and HIV-TB co-infection.…”

Section: Discussionsupporting

confidence: 92%

The Occurrence of Tuberculosis Infection among Newly HIV Diagnosed Patient in Indonesia

Gumilang

Indriati

Diyantoro

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Human immunodeficiency virus (HIV) is a big threat to Indonesia and the rest of the world. People with HIV are more prone to opportunistic diseases like tuberculosis (TB) because HIV damages the immune system. AIM: This study aims to determine the prevalence and risk factors (age and gender) that contribute to pulmonary TB among HIV/AIDS patients admitted to Genteng Hospital Banyuwangi. METHODS: This research uses the Observational Analytical, Cross-Sectional method. We collected data from 372 new diagnosed HIV patients between 2019 and 2021. HIV diagnosis was obtained with a rapid test method. At the same time, a pulmonary TB diagnosis was obtained with Xpert MTB/RIF. RESULTS: We found that 372 individuals were HIV positive, and 63 patients among them were also positive for TB (16.93%). The majority of individuals were male (53.22%), in the age group of adults (26–45 years old) (62.1%). While HIV-TB patients were found among those in adult age group (16.13%), all patients positive with HIV-TB still susceptible to rifampicin treatment. The prevalence of TB among HIV patients did not differ significantly by gender or age. CONCLUSION: We found TB co-infection in newly diagnosed HIV patients. Individuals at risk of HIV infection should be screened early to minimize co-infection with other diseases that can aggravate their condition. As a result, the severity and death rate of HIV patients can be reduced in the long run.

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Section: Discussionsupporting

confidence: 92%

The Occurrence of Tuberculosis Infection among Newly HIV Diagnosed Patient in Indonesia

Gumilang

Indriati

Diyantoro

et al. 2022

Open Access Maced J Med Sci

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“…The assays used in the present study to detect SARS-CoV-2 specific response are easy and highly reproducible (17,(33)(34)(35)(36)(37)(38), and therefore are compatible with the routine monitoring of vaccinated individuals (4,5,16). Indeed, the T-cell response was detected by a whole blood assay, whose platform is similar to current tests measuring T-cell-specific responses against M. tuberculosis in both immune-competent and immunesuppressed subjects (39)(40)(41)(42).…”

Section: Discussionmentioning

confidence: 84%

ImmunosuppressiveTherapies Differently Modulate Humoral- and T-Cell-Specific Responses to COVID-19 mRNA Vaccine in Rheumatoid Arthritis Patients

et al. 2021

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ObjectiveTo assess in rheumatoid arthritis (RA) patients, treated with different immunosuppressive therapies, the induction of SARS-CoV-2-specific immune response after vaccination in terms of anti-region-binding-domain (RBD)-antibody- and T-cell-specific responses against spike, and the vaccine safety in terms of clinical impact on disease activity.MethodsHealth care workers (HCWs) and RA patients, having completed the BNT162b2-mRNA vaccination in the last 2 weeks, were enrolled. Serological response was evaluated by quantifying anti-RBD antibodies, while the cell-mediated response was evaluated by a whole-blood test quantifying the interferon (IFN)-γ-response to spike peptides. FACS analysis was performed to identify the cells responding to spike stimulation. RA disease activity was evaluated by clinical examination through the DAS28crp, and local and/or systemic clinical adverse events were registered. In RA patients, the ongoing therapeutic regimen was modified during the vaccination period according to the American College of Rheumatology indications.ResultsWe prospectively enrolled 167 HCWs and 35 RA patients. Anti-RBD-antibodies were detected in almost all patients (34/35, 97%), although the titer was significantly reduced in patients under CTLA-4-inhibitors (median: 465 BAU/mL, IQR: 103-1189, p<0.001) or IL-6-inhibitors (median: 492 BAU/mL, IQR: 161-1007, p<0.001) compared to HCWs (median: 2351 BAU/mL, IQR: 1389-3748). T-cell-specific response scored positive in most of RA patients [24/35, (69%)] with significantly lower IFN-γ levels in patients under biological therapy such as IL-6-inhibitors (median: 33.2 pg/mL, IQR: 6.1-73.9, p<0.001), CTLA-4-inhibitors (median: 10.9 pg/mL, IQR: 3.7-36.7, p<0.001), and TNF-α-inhibitors (median: 89.6 pg/mL, IQR: 17.8-224, p=0.002) compared to HCWs (median: 343 pg/mL, IQR: 188-756). A significant correlation between the anti-RBD-antibody titer and spike-IFN-γ-specific T-cell response was found in RA patients (rho=0.432, p=0.009). IFN-γ T-cell response was mediated by CD4+ and CD8+ T cells. Finally, no significant increase in disease activity was found in RA patients following vaccination.ConclusionThis study showed for the first time that antibody-specific and whole-blood spike-specific T-cell responses induced by the COVID-19 mRNA-vaccine were present in the majority of RA patients, who underwent a strategy of temporary suspension of immunosuppressive treatment during vaccine administration. However, the magnitude of specific responses was dependent on the immunosuppressive therapy administered. In RA patients, BNT162b2 vaccine was safe and disease activity remained stable.

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“…In developed countries with low TB and HIV burden, the compliance of HIV services in implementing LTBI screening was often inadequate. The LTBI screening rates among HIV-infected patients in United Kingdom, United States, New Zealand and Italy was 35%, 32%, 55% and 65% respectively (Ogbonnaya et al, 2015;White et al, 2017;Adams et al, 2017;Goletti et al, 2020). A study done by Goletti et al demonstrated that LTBI tests were inconsistently performed and were done more frequently on foreign-born patients, older individuals and those with low CD4 cell count (Goletti et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…The LTBI screening rates among HIV-infected patients in United Kingdom, United States, New Zealand and Italy was 35%, 32%, 55% and 65% respectively (Ogbonnaya et al, 2015;White et al, 2017;Adams et al, 2017;Goletti et al, 2020). A study done by Goletti et al demonstrated that LTBI tests were inconsistently performed and were done more frequently on foreign-born patients, older individuals and those with low CD4 cell count (Goletti et al, 2020). The local medical community can further improve on latent TB infection care to prevent active TB in the HIV population especially in a period of the COVID-19 pandemic to reach targets to end TB (Abri et al, 2020;Migliori et al, 2020;Zumla et al, 2021;Chakaya et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Lack of latent tuberculosis (TB) screening and delay in anti-retroviral therapy initiation in HIV-TB co-infection: an 11-year study in an intermediate TB-burden country

Teng

Chua

Lai

et al. 2021

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Latent tuberculosis infection screening in persons newly-diagnosed with HIV infection in Italy: A multicentre study promoted by the Italian Society of Infectious and Tropical Diseases

Cited by 16 publications

References 28 publications

The Occurrence of Tuberculosis Infection among Newly HIV Diagnosed Patient in Indonesia

The Occurrence of Tuberculosis Infection among Newly HIV Diagnosed Patient in Indonesia

ImmunosuppressiveTherapies Differently Modulate Humoral- and T-Cell-Specific Responses to COVID-19 mRNA Vaccine in Rheumatoid Arthritis Patients

Lack of latent tuberculosis (TB) screening and delay in anti-retroviral therapy initiation in HIV-TB co-infection: an 11-year study in an intermediate TB-burden country

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