Latent variable analysis of negative affect and its contributions to neural responses during shock anticipation

Kirlić, Namik; Aupperle, Robin L.; Rhudy, Jamie L.; Misaki, Masaya; Kuplicki, Rayus; Sutton, Anne F.; Alvarez, Ruben P.

doi:10.1038/s41386-018-0187-5

Cited by 17 publications

(13 citation statements)

References 45 publications

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“…Several studies have documented effects of anxiety on neural processing and reporting of pain. 32 , 48 , 64 Pain-related anxiety in ASD could contribute to or arise due to altered neural processing of pain. In ASD, reports of heightened responses in the anterior cingulate during pain anticipation 24 and substantial late phase suppression of the neural pain signature during a painful stimulus 17 are consistent with increased pain-related anxiety and varying profiles of pain sensitivity based on the temporal profile of the stimuli as reported in this study.…”

Section: Discussionmentioning

confidence: 99%

Increased pain sensitivity and pain-related anxiety in individuals with autism

Failla

Gerdes

Williams

et al. 2020

PR9

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Introduction: Individuals with autism spectrum disorder (ASD) often exhibit differences in pain responsivity. This altered responsivity could be related to ASD-related social communication difficulties, sensory differences, or altered processing of pain stimuli. Previous neuroimaging work suggests altered pain evaluation could contribute to pain-related anxiety in ASD. Objectives: We hypothesized that individuals with ASD would report increased pain sensitivity and endorse more pain-related anxiety, compared to typically developing controls. Methods: We recruited 43 adults (ASD, n = 24; typically developing, n = 19) for 3 heat pain tasks (applied to the calf). We measured heat pain thresholds using a method of limits approach, a pain-rating curve (7 temperatures between 40 and 48°C, 5 seconds, 5 trials each), and a sustained heat pain task with alternating low (42°C) and high (46°C) temperatures (21 seconds, 6 trials each). Individual differences in pain-related anxiety, fear of pain, situational pain catastrophizing, depressive symptoms, and autism-related social communication were assessed by self-report. Results: There were no group differences in pain thresholds. For suprathreshold tasks, mean pain ratings were higher in ASD across both the pain-rating curve and the sustained heat pain tasks, but responses in the ASD group were more varied. Pain anxiety (PASS-Total) and pain-related fear (FOP-III-Total) were higher in the ASD group and were positively associated with pain ratings. Conclusions: Our results suggest that both sensory and cognitive experiences of pain are heightened and interact reciprocally in adults with ASD. Future studies are needed to evaluate the impact of pain-related anxiety on treatment-seeking and pain behaviors, given higher levels of pain-related anxiety in ASD.

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Section: Discussionmentioning

confidence: 99%

Increased pain sensitivity and pain-related anxiety in individuals with autism

Failla

Gerdes

Williams

et al. 2020

PR9

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“…The neural circuits governing trait-like individual differences in dispositional negativity have only recently started to come into focus. Work by our group and others demonstrates that humans and monkeys with a more negative disposition show heightened responses to threatrelevant cues in a number of brain regions, including the amygdala, anterior hippocampus, anterior insula, bed nucleus of the stria terminalis (BST), mid-cingulate cortex, orbitofrontal cortex, and periaqueductal gray (Avery, Clauss, & Blackford, 2016;Cavanagh & Shackman, 2015;Fox & Kalin, 2014b;Fox & Shackman, 2019;Kalin, 2017;Kirlic et al, 2019;Lowery-Gionta, DiBerto, Mazzone, & Kash, 2018;Shackman et al, 2011b;Shackman et al, 2016c). While all of these regions are important, here we focus on the most intensely scrutinized component of this system, the amygdala, a heterogeneous collection of nuclei buried beneath the temporal lobe (Freese & Amaral, 2009; Yilmazer-Hanke, 2012) (Figure 1).…”

Section: Relevance Of the Amygdala To Dispositional Negativitymentioning

confidence: 98%

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

Hur

Stockbridge

Fox

et al. 2019

Progress in Brain Research

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When extreme, anxiety can become debilitating. Anxiety disorders, which often first emerge early in development, are common and challenging to treat, yet the underlying mechanisms have only recently begun to come into focus. Here, we review new insights into the nature and biological bases of dispositional negativity, a fundamental dimension of childhood temperament and adult personality and a prominent risk factor for the development of pediatric and adult anxiety disorders. Converging lines of epidemiological, neurobiological, and mechanistic evidence suggest that dispositional negativity increases the likelihood of psychopathology via specific neurocognitive mechanisms, including attentional biases to threat and deficits in executive control. Collectively, these observations provide an integrative translational framework for understanding the development and maintenance of anxiety disorders in adults and youth and set the stage for developing improved intervention strategies.

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“…To be clear, the distinction made here between affect-based conflict and pain- or monetary-based conflict is not meant to suggest that losing money or feeling the unpleasant sensation of pain do not involve affective responses. 21 The distinction motivating the use of affect-based tasks is one of maximizing ecological validity: affective disorders more often involve avoidance of the more complex “emotional pain” induced by socio-emotional cues (e.g., social rejection, losing a job, death). The visual/auditory stimuli used in affect-based AAC tasks are designed to more closely match such cues (e.g., by depicting social interactions mirroring some of those cues) and the emotionally painful responses they evoke.…”

Section: Introductionmentioning

confidence: 99%

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

Smith

Kirlić

Stewart

et al. 2021

jpn

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Background: Imbalances in approach-avoidance conflict (AAC) decision-making (e.g., sacrificing rewards to avoid negative outcomes) are considered central to multiple psychiatric disorders. We used computational modelling to examine 2 factors that are often not distinguished in descriptive analyses of AAC: decision uncertainty and sensitivity to negative outcomes versus rewards (emotional conflict). Methods: A previously validated AAC task was completed by 478 participants, including healthy controls (n = 59), people with substance use disorders (n = 159) and people with depression and/or anxiety disorders who did not have substance use disorders (n = 260). Using an active inference model, we estimated individual-level values for a model parameter that reflected decision uncertainty and another that reflected emotional conflict. We also repeated analyses in a subsample (59 healthy controls, 161 people with depression and/or anxiety disorders, 56 people with substance use disorders) that was propensity-matched for age and general intelligence. Results: The model showed high accuracy (72%). As further validation, parameters correlated with reaction times and self-reported task motivations in expected directions. The emotional conflict parameter further correlated with self-reported anxiety during the task (r = 0.32, p < 0.001), and the decision uncertainty parameter correlated with self-reported difficulty making decisions (r = 0.45, p < 0.001). Compared to healthy controls, people with depression and/or anxiety disorders and people with substance use disorders showed higher decision uncertainty in the propensity-matched sample (t = 2.16, p = 0.03, and t = 2.88, p = 0.005, respectively), with analogous results in the full sample; people with substance use disorders also showed lower emotional conflict in the full sample (t = 3.17, p = 0.002). Limitations: This study was limited by heterogeneity of the clinical sample and an inability to examine learning. Conclusion: These results suggest that reduced confidence in how to act, rather than increased emotional conflict, may explain maladaptive approach-avoidance behaviours in people with psychiatric disorders.

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Latent variable analysis of negative affect and its contributions to neural responses during shock anticipation

Cited by 17 publications

References 45 publications

Increased pain sensitivity and pain-related anxiety in individuals with autism

Increased pain sensitivity and pain-related anxiety in individuals with autism

Dispositional negativity, cognition, and anxiety disorders: An integrative translational neuroscience framework

Greater decision uncertainty characterizes a transdiagnostic patient sample during approach-avoidance conflict: a computational modelling approach

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