Latenzzeit zwischen Exposition und Symptomen bei Allergie gegen Naturlatex: Vorschläge zur Prävention

Allmers, H.; Kirchner, Babette; Huber, Hugo; Chen, Z.; Walther, J.; Baur, Xaver

doi:10.1055/s-2008-1043073

Cited by 11 publications

(1 citation statement)

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“…Differently from other previous papers which have considered only a subset of baseline measurements, our data include several clinical and functional findings which may be measured in these patients, including also the evaluation of the level of eosinophilic airway inflammation and the pattern of response to SIC. In effect, previous studies have shown that patients with LMWC-induced asthma had a greater duration of exposure to the specific sensitizer before the beginning of asthma symptoms than patients with HMCW-induced asthma [14, 15], or that LMWC asthma showed less frequent sputum eosinophilia [5] or a lower frequency of immediate airway response to SIC [3, 16]. All these data have been confirmed in our study which included a large set of clinical, functional, and biological findings of the disease at the baseline assessment.…”

Section: Discussionmentioning

confidence: 99%

Comparison between Airway Responses to High versus Low Molecular Weight Compounds in Occupational Asthma

Talini¹,

Novelli

Bacci

et al. 2011

Journal of Allergy

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Occupational asthma (OA) is a heterogeneous disease, and the characteristics of the sensitizer responsible for OA may induce different clinical, functional, and biological manifestations. We examined the characteristics of 74 patients with OA induced by low molecular weight compounds (LMWC) or by high molecular weight compounds (HMWC) and diagnosed by specific inhalation challenge (SIC). Patients with OA induced by LMWC had a longer occupational exposure before the beginning of symptoms, a lower sputum eosinophilia, and a higher prevalence of late airway response (LAR), in comparison with patients with OA induced by HMWC. Pulmonary function tended to be poorer and atopy tended to be less frequent in LMWC-induced OA than in HMWC-induced OA. These data confirm and extend previous observations showing that the characteristics of the specific sensitizer inducing OA may determine different clinical, functional, and biological features, probably related to the difference pathogenetic mechanisms underlying these different types of OA.

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