2024
DOI: 10.1371/journal.pone.0305526
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Later-age neutering causes lower risk of early‐onset urinary incontinence than early neutering–a VetCompass target trial emulation study

Camilla Pegram,
Karla Diaz-Ordaz,
Dave C. Brodbelt
et al.

Abstract: There is growing evidence supporting clinically important associations between age at neutering in bitches and subsequent urinary incontinence (UI), although much of this evidence to date is considered weak. Target trial emulation is an innovative approach in causal inference that has gained substantial attention in recent years, aiming to simulate a hypothetical randomised controlled trial by leveraging observational data. Using anonymised veterinary clinical data from the VetCompass Programme, this study app… Show more

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