Lateral cerebellar nucleus stimulation promotes motor recovery and suppresses neuroinflammation in a fluid percussion injury rodent model

Chan, Hugh H.; Wathen, Connor; Mathews, Nicole D.; Hogue, Olivia; Modic, James P.; Kundalia, Ronak; Wyant, Cara; Park, Hyun-Joo; Najm, Imad; Trapp, Bruce D.; Machado, André G.; Baker, Kenneth B.

doi:10.1016/j.brs.2018.07.051

Cited by 31 publications

(37 citation statements)

References 81 publications

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“…[58] The sensory input training strategy may enhance motor rehabilitation through anti-apoptotic, neuroprotective, and anti-inflammatory effects. [59]…”

Section: Clinical Rehabilitation Technologies Based On Sensory Inputmentioning

confidence: 99%

Therapeutic effects of sensory input training on motor function rehabilitation after stroke

Chen

Liu²,

Yan³

et al. 2018

Medicine

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Motor dysfunction is a common and severe complication of stroke that affects the quality of life of these patients. Currently, motor function rehabilitation predominantly focuses on active movement training; nevertheless, the role of sensory input is usually overlooked. Sensory input is very important to motor function. Voluntary functional movement necessitates preparation, execution, and monitoring functions of the central nervous system, while the monitoring needs the participation of the sensory system. Sensory signals affect motor functions by inputting external environment information and intrinsic physiological status as well as by guiding initiation of the motor system. Recent studies focusing on sensory input-based rehabilitation training for post-stroke dyskinesia have demonstrated that sensory function has significant effects on voluntary functional movements. In conclusion, sensory input plays a crucial role in motor function rehabilitation, and the combined sensorimotor training modality is more effective than conventional motor-oriented approaches.

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“…[58] The sensory input training strategy may enhance motor rehabilitation through anti-apoptotic, neuroprotective, and anti-inflammatory effects. [59]…”

Section: Clinical Rehabilitation Technologies Based On Sensory Inputmentioning

confidence: 99%

Therapeutic effects of sensory input training on motor function rehabilitation after stroke

Chen

Liu²,

Yan³

et al. 2018

Medicine

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“…The DRTT is a bundle that originates from the DN, runs in the SCP, and then mainly decussates to the contralateral RN to ascend to the thalamus and finally to the cortex. [ 5 , 19 , 26 ] In all cases, we obtained the tractography of the DRTT bilaterally and we aimed for the contacts to be close or within the projection of DRTT.…”

Section: Discussionmentioning

confidence: 99%

“…Thus far, small improvements were noted, DN DBS was effective for treating ataxia in SCA type 3, cerebellar stroke, dystonia, and essential tremor. [ 5 , 9 , 10 , 18 , 25 , 35 ]…”

Section: Introductionmentioning

confidence: 99%

Dentate nucleus deep brain stimulation: Technical note of a novel methodology assisted by tractography

Diniz

Cury

Iglesio

et al. 2021

Surgical Neurology International

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Background: The cerebellum has emerged as an attractive and promising target for neuromodulation in movement disorders due to its vast connection with important cortical and subcortical areas. Here, we describe a novel technique of deep brain stimulation (DBS) of the dentate nucleus (DN) aided by tractography. Methods: Since 2015, patients with movement disorders including dystonia, ataxia, and tremor have been treated with DN DBS. The cerebellar target was initially localized using coordinates measured from the fastigial point. The target was adjusted with direct visualization of the DN in the susceptibility-weighted imaging and T2 sequences of the MRI and finally refined based on the reconstruction of the dentatorubrothalamic tract (DRTT). Results: Three patients were treated with this technique. The final target was located in the anterior portion of DN in close proximity to the DRTT, with the tip of the lead on the white matter and the remaining contacts on the DN. Clinical outcomes were variable and overall positive, with no major side effect. Conclusion: Targeting the DN based on tractography of the DRTT seems to be feasible and safe. Larger studies will be necessary to support our preliminary findings.

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“…The combination of a PDMS window with the ET-1 stroke model (Fig. 2) also allows targeting several injuries to cortical and sub-cortical regions without interfering with the activity recording, by using either multiple simultaneous injections [58,[70][71][72][73] or by sequential injections to study the effects of consecutive stroke events. Additional recording techniques, such as implanted multisite electrodes [74], implanted optical fibers, or fMRI studies, may expand the proposed framework to provide functional information on subcortical brain regions that are not easily accessible using TPLSM.…”

Section: Discussionmentioning

confidence: 99%

Cellular-resolution monitoring of ischemic stroke pathologies in the rat cortex

Chornyy

Das

Borovicka

et al. 2021

Preprint

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Stroke is a leading cause of disability in the Western world. Current post-stroke rehabilitation treatments are only effective in approximately half of the patients. Therefore, there is a pressing clinical need for developing new rehabilitation approaches for enhancing the recovery process, which requires the use of appropriate animal models. Here we study the activity patterns of multiple cortical regions in the rat brain using two-photon microscopy. We longitudinally recorded the fluorescence signal from thousands of neurons labeled with a genetically-encoded calcium indicator before and after an ischemic stroke injury, and found substantial functional changes across motor, somatosensory, and visual cortical regions during the post-stroke cortical reorganization period. We show that a stroke injury in the primary motor cortex has an effect on the activity patterns of neurons not only in the motor and somatosensory cortices, but also in the more distant visual cortex, and that these changes include modified firing rates and kinetics of neuronal activity patterns in response to a sensory stimulus. Changes in neuronal population activity provided animal-specific, circuit-level information on the post-stroke cortical reorganization process, which may be essential for evaluating the efficacy of new approaches for enhancing the recovery process.

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Lateral cerebellar nucleus stimulation promotes motor recovery and suppresses neuroinflammation in a fluid percussion injury rodent model

Cited by 31 publications

References 81 publications

Therapeutic effects of sensory input training on motor function rehabilitation after stroke

Therapeutic effects of sensory input training on motor function rehabilitation after stroke

Dentate nucleus deep brain stimulation: Technical note of a novel methodology assisted by tractography

Cellular-resolution monitoring of ischemic stroke pathologies in the rat cortex

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