Lateral diffusion of saturated phosphatidylcholines in cholesterol-containing bilayers

Lateral diffusion in sphingomyelin bilayers

“…The calculated E D values are 36.6 (DPPC), 43 (eSM) and 44 kJ/mol (PSM, bSM and mSM), which agree with the earlier published results 36 kJ/mol for DPPC [28] and 40-44 kJ/mol for SMs. [26] Another peculiarity of natural SM diffusion is the deviation of the forms of DDs from the monoexponential function (1).…”

“…[28,39] Alongside this, LDCs of SMs are essentially less and E D of SMs are higher than that of DPPC at comparable molecular masses (M of DPPC is 734 Da, while that of SMs is in the range of 703-801 Da, according to the 'Avanti' data). This effect has been observed earlier [23,26] in bilayers of eSM; however, here we can, for the first time, directly compare DPPC and PSM, both of which are homogeneous in molecular composition and have identical polar and hydrophobic parts but differ only in molecular base structure (glycerol and sphingosine, respectively).…”

“…Recently, on an example of PC it has been demonstrated that at the same temperature and hydration, dimyristoylPC is characterized by higher values of D L than DPPC. [28] While the difference in molecular masses of these lipids was approximately 8%, the divergence in diffusion coefficients was on the order of 30% in the temperature range [45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60] • C. However, one-phase bilayer prepared from the mixture of phospholipids shows convergence of D L s of individual values inherent to individual lipids to the same mean value, while DD remains near-exponential in form. This was demonstrated on an example of bilayers prepared from an equimolar mixture of dioleoylPC and eSM.…”

“…Earlier studies showed that the DD non-exponentiality in lipid-oriented bilayers can be conditioned by the bilayer heterogeneity, particularly due to the liquid-crystalline phase decomposition. [24,26,28] In that case, DD was the sum of two exponential terms of type (1), with LDCs differing by 1.5-5-fold. It has been suggested that phase decomposition is the result of noncompatibility of different types of lipids under certain circumstances, such as the presence of cholesterol.…”

Binding of a Ruthenium Complex to a Thioether Ligand Embedded in a Negatively Charged Lipid Bilayer: A Two‐Step Mechanism

“…Although rather different metal-ligand systems show quite similar behavior, [59] the generality of this mechanism will need to be evaluated. Indeed, although the charge of metal cations is an important parameter for their adsorption to lipid bilayers, other parameters such as the nature of the metal, the ligands that may be coordinated to it, the number of coordination sites available, the presence of cholesterol or cholesterol derivatives in the membrane, [60][61][62][63][64][65][66] and also the surrounding environment (ionic force, pH, etc. ), can all have a strong influence on the adsorption process.…”