Lateral hypothalamic neuronal ensembles regulate pre-sleep nest-building behavior

Sotelo, María Inés; Tyan, Jean; Markunas, Chelsea; Sulaman, Bibi A.; Horwitz, Lorraine; Lee, Han Kyu; Morrow, Joshua G.; Rothschild, Gideon; Duan, Bo; Eban-Rothschild, Ada

doi:10.1016/j.cub.2021.12.053

Cited by 28 publications

(29 citation statements)

References 80 publications

(127 reference statements)

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“…Starting from an unbiased whole-brain survey of activity patterns elicited in different contexts, we associate a group of midbrain neurons, the EWcp CART+ , with maternal behavior. Of note, nesting is most often performed as the first step of a behavioral sequence that leads the animal to sleep ( Eban-Rothschild et al., 2016 ; Sotelo, 2022 ). Our data suggest that the activity of the EWcp CART+ neurons acutely influences the transition to nesting in the wake-to-sleep sequence, and their inhibition is detrimental to the duration of the nesting phase in the sequence.…”

Section: Discussionmentioning

confidence: 99%

“…In laboratory settings, mice reorganize their nest daily: in the dark phase, the nest is disorganized by the normal activities of mice but is rebuilt in the same location at the beginning of the light phase before rest ( Jirkof, 2014 ; Jirkof et al., 2013 ). As a result, nest building happens at the start of a behavioral sequence, which consists of nesting, grooming, and then sleep ( Eban-Rothschild et al., 2016 , 2017 ; Sotelo, 2022 ). We reasoned that preparatory nesting could modify profoundly some of the essential behaviors in the daily routine of pregnant females.…”

Section: Introductionmentioning

confidence: 99%

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Edinger-Westphal peptidergic neurons enable maternal preparatory nesting

Topilko

Diaz

Pacheco

et al. 2022

Neuron

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Edinger-Westphal peptidergic neurons enable maternal preparatory nesting

Topilko

Diaz

Pacheco

et al. 2022

Neuron

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“…It is commonly experience that the pre-sleep period is characterized by a series of motivational drives that can significantly modulate sleep [ 17 , 18 ]. In several animal species, the engagement of pre-sleep behaviors has also been documented in terms of changes in neuronal function and interpreted as an important evolutionary adaptation [ 19 ]. In humans, pre-sleep behaviors are thought to facilitate the transition from wakefulness to sleep by reducing alertness and limiting exposure to environmental, activating stimuli.…”

Section: Introductionmentioning

confidence: 99%

Time Course of Motor Activity Wake Inertia Dissipation According to Age

et al. 2022

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The time course of motor activity sleep inertia (maSI) dissipation was recently investigated through actigraphy in an everyday life condition from middle childhood to late adulthood. Motor activity sleep inertia was dissipated in 70 min, and the sleep inertia phenomenon was more evident in younger participants than in older participants. The aim of the current secondary analysis of previously published data was to examine, within the same sample, the time course of motor activity wake inertia (maWI) dissipation, i.e., the motor pattern in the transition phase from wakefulness to sleep, according to age. To this end, an overall sample of 374 participants (215 females), ranging in age between 9 and 70 years old, was examined. Each participant was asked to wear an actigraph around their non-dominant wrist for one week. The variation in the motor activity pattern of the wake–sleep transition according to age was examined through functional linear modeling (FLM). FLM showed that motor activity wake inertia dissipated around 20 min after bedtime. Moreover, a lower age was significantly associated with greater motor activity within the last two hours of wakefulness and the first twenty minutes after bedtime. Overall, this pattern of results seems to suggest that maWI dissipation is comparable to that of maSI.

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“…Thus, alterations in sleep and diurnal rhythms, like those observed with feeding behavior, may provide one explanation for why AUD increases AD risk. Interestingly, a recent study also demonstrated that nest-building increases during proximity to sleep in mice (Sotelo, Tyan et al 2022). Although further studies are needed, these findings suggest that chronic ethanol drinking exacerbates disruptions in metabolism and sleep that are frequently observed in AD.…”

Section: Discussionmentioning

confidence: 97%

Ethanol exposure alters Alzheimer’s-related pathology, behavior, and metabolism in APP/PS1 mice

Gironda

Day

Clarke

et al. 2022

Preprint

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Epidemiological studies suggest that alcohol use disorder (AUD) is a risk factor for Alzheimer's disease (AD), yet the mechanisms underlying this relationship are poorly understood. Preclinical studies consistently show that chronic, high dose ethanol exposure increases amyloid-β (Aβ) and tau pathology, hallmarks of AD, in rodent models. Conversely, other studies suggest that moderate ethanol consumption may also be protective against AD-related pathology. Thus, we used a modified two-bottle choice paradigm to identify how chronic ethanol exposure, at moderate levels, alters Aβ-related pathology, cognitive performance, and metabolism. Over the course of the experiment, APP/PS1 mice consumed more ethanol than wild-type mice. This led to changes in food and water consumption in APP/PS1 mice, where ethanol-exposed APP/PS1 mice displayed a circadian shift in eating behavior. Ethanol-exposed APP/PS1 mice displayed glucose intolerance, a marker of insulin resistance, even though fasting blood glucose levels and body weights were comparable across all groups. Ethanol-exposed APP/PS1 mice exhibited deficits in nest building, a metric of self-care, as well as increased locomotor activity and central zone exploration in an open field test. Ethanol exposure also led to decreased brain mass, specifically in APP/PS1 mice, suggesting an interaction between ethanol exposure, amyloid pathology, and neurodegeneration. While there was a trend towards increased cortical Aβ deposition, there was a shift in the distribution of plaque size and numbers, with ethanol-exposed APP/PS1 mice showing a greater number of smaller plaques than H2O-exposed APP/PS1 mice. Finally, we used in vivo microdialysis to explore whether acute ethanol modulates hippocampal interstitial fluid (ISF) Aβ and ISF glucose levels in unrestrained, APP/PS1 mice. Acute intraperitoneal injection of ethanol led to a rapid rise in ISF ethanol and directly ISF Aβ (e.g. decreasing during acute exposure and increasing during acute withdrawal), and ISF glucose levels in the hippocampus. Together, these studies indicate that chronic ethanol, even at moderate doses, is sufficient to exacerbate an Alzheimer's-like phenotype in APP/PS1 mice through the direct modulation of Aβ.

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Lateral hypothalamic neuronal ensembles regulate pre-sleep nest-building behavior

Cited by 28 publications

References 80 publications

Edinger-Westphal peptidergic neurons enable maternal preparatory nesting

Edinger-Westphal peptidergic neurons enable maternal preparatory nesting

Time Course of Motor Activity Wake Inertia Dissipation According to Age

Ethanol exposure alters Alzheimer’s-related pathology, behavior, and metabolism in APP/PS1 mice

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