Lateral septum inhibition reduces motivation for cocaine: Reversal by diazepam

Pantazis, Caroline B.; Aston‐Jones, Gary

doi:10.1111/adb.12742

Cited by 18 publications

(14 citation statements)

References 42 publications

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“…Similar volumetric abnormalities have also been reported for the animal model used in this study [24,45]. In addition, the method also detected the medial septum, which plays a significant role in dopamine-related disorders such as schizophrenia [46,47] and addictions [48][49][50], which highlights the relevance of this structure in mental disorders. Regarding WM, the method found three well-defined brain areas, the frontal part of corpus callosum and WM tracts of the brainstem and the cerebellum [51,52].…”

Section: Discussionsupporting

confidence: 85%

A Novel Bayesian Linear Regression Model for the Analysis of Neuroimaging Data

et al. 2022

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In this paper, we propose a novel Machine Learning Model based on Bayesian Linear Regression intended to deal with the low sample-to-variable ratio typically found in neuroimaging studies and focusing on mental disorders. The proposed model combines feature selection capabilities with a formulation in the dual space which, in turn, enables efficient work with neuroimaging data. Thus, we have tested the proposed algorithm with real MRI data from an animal model of schizophrenia. The results show that our proposal efficiently predicts the diagnosis and, at the same time, detects regions which clearly match brain areas well-known to be related to schizophrenia.

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Section: Discussionsupporting

confidence: 85%

A Novel Bayesian Linear Regression Model for the Analysis of Neuroimaging Data

et al. 2022

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“…These changes are indicative that the LS adapts to drug intake and may subsequently affect drug-seeking behaviors. On the other hand, pharmacological inhibition of the LS by baclofen-muscimol injection reduces motivation to indulge in drug-seeking behavior ( Pantazis and Aston-Jones, 2020 ). Additionally, intra-LS injections of opioid receptor antagonists block behavioral sensitization to morphine ( Li et al, 2021 ).…”

Section: Ls-associated Circuitry In Rewardmentioning

confidence: 99%

Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways

Rizzi-Wise

Wang

2021

eNeuro

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The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as a structure of homogeneity, exhibits such multifaceted functions. Emerging evidence suggests that different functions of the LS are mediated largely by its diverse input and output connections. It has also become clear that the LS is a heterogeneous region, where its dorsal and ventral poles play dissociable and often opposing roles. This functional heterogeneity can often be explained by distinct dorsal and ventral hippocampal inputs along the LS dorsoventral axis, as well as antagonizing connections between LS subregions. Similarly, outputs from LS subregions to respective downstream targets, such as hypothalamic, preoptic, and tegmental areas, also account for this functional heterogeneity. In this review, we provide an updated perspective on LS subregion classification, connectivity, and functions. We also identify key questions that have yet to be addressed in the field.

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“…This general hypothesis is supported by work from the Aston-Jones lab that found increased septal cfos activity during cocaine-seeking behavior [39]. Furthermore, inactivation of the septum blocked contextual- and cue-induced reinstatement for cocaine [40], and attenuates motivated responding [41], supporting a role for the septum in relapse-like behavior.…”

Section: Introductionmentioning

confidence: 77%

Activation of the dorsal septum increases alcohol consumption in male C57BL/6J mice

Haun¹,

D’Ambrosio²,

Kash

2022

Preprint

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Binge drinking is a common pattern of excessive alcohol consumption associated with Alcohol Use Disorder (AUD) and unraveling the neurocircuitry that promotes this type of drinking is critical to the development of novel therapeutic interventions. The septal region was once a focal point of alcohol research yet has seen limited study over the last decade in relation to binge drinking. Numerous studies point to involvement of the dorsal septum (dSep) in excessive drinking and withdrawal, but few studies have manipulated this region in the context of binge drinking behavior. The present experiments were primarily designed to determine the effect of chemogenetic manipulation of the dSep on binge-like alcohol drinking in male and female C57BL/6J mice. Mice received bilateral infusion of AAVs harboring hM4Di, hM3Dq, or mCherry into the dSep and subjects were challenged with systemic administration of clozapine-N-oxide (CNO; 3 mg/kg) or vehicle (saline; 0.9%) in the context of binge-like alcohol consumption, locomotor activity, and sucrose drinking. CNO-mediated activation (hM3Dq) of the dSep resulted in a significant increase in binge-like alcohol consumption, locomotor activity, and sucrose intake in male mice. DSep activation promoted sucrose drinking in female mice, but alcohol intake and locomotor activity were unaffected. Conversely, silencing (hM4Di) of the dSep modestly decreased locomotor activity in males and did not influence alcohol or sucrose intake in either sex. Lastly, CNO was without effect in mCherry-expressing control groups. These data support a role for the dSep in promoting excessive, binge-like drinking behavior in a sex-dependent fashion and suggests a broad role for the region in the modulation of locomotor activity as well as general appetitive behavior such as sucrose drinking.

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Lateral septum inhibition reduces motivation for cocaine: Reversal by diazepam

Cited by 18 publications

References 42 publications

A Novel Bayesian Linear Regression Model for the Analysis of Neuroimaging Data

A Novel Bayesian Linear Regression Model for the Analysis of Neuroimaging Data

Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways

Activation of the dorsal septum increases alcohol consumption in male C57BL/6J mice

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