Lateral sinus thrombosis and intracranial hypertension in essential thrombocythaemia.

Mitchell, David C.; Fisher, J; Irving, Doreen; Gazzard, Brian; Guiloff, R J

doi:10.1136/jnnp.49.2.218

Cited by 22 publications

(5 citation statements)

References 2 publications

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“…Three of our thirteen patients suffered potentially life-threatening events, demonstrating that youth is not protective against the more catastrophic complications of ET. Others have observed serious thrombotic complications in younger patients as well, including splenic [6] and cerebral [7,8] venous thromboses. A review of the neurologic manifestations of ET found no difference in age between symptomatic and asymptomatic patients [9].…”

Section: Discussionmentioning

confidence: 99%

Clinical manifestations of essential thrombocythemia in young adults

et al. 1990

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Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by isolated overproduction of platelets, thrombohemorrhagic complications, and a median age of 50-60. When it occurs in younger patients, the incidence of complications has been reported to be quite low, with a good long-term prognosis. We report a retrospective review of 13 patients with ET between the ages of 22 and 35 in which 11 were symptomatic at diagnosis, with only one remaining asymptomatic during follow-up. Three patients presented with potentially life-threatening complications (two myocardial infarctions, one stroke), although no deaths were observed. The majority of the nonlife-threatening complications were vaso-occlusive in nature, including erythromelalgia and transient neurologic symptoms. We conclude that ET in young adults is not always a benign disease and that potentially life-threatening complications are not rare. The optimum approach to treatment in this or any other age group remains uncertain.

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Section: Discussionmentioning

confidence: 99%

Clinical manifestations of essential thrombocythemia in young adults

et al. 1990

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“…These associations include the thrombophilias [81,101,112,119] as well as other prothrombotic states such as essential [118] and iron deficiency anaemia [69]. This association between prothrombotic conditions and PTS was reviewed by Sussman et al [169].…”

Section: Venous Sinus Obstruction In Pseudotumor Cerebri Syndromementioning

confidence: 98%

Cranial Venous Outflow Obstruction and Pseudotumor Cerebri Syndrome

Owler

Parker

Hálmagyi

et al. 2005

Advances and Technical Standards in Neurosurgery

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“…Several hematological disorders have been linked to CVST; these are polycythemia [184], paroxysmal nocturnal hemoglobinuria [185], sickle cell disease [186][187][188][189][190][191], idiopathic hypereosinophilic syndrome [192], hemolytic anemia [75], and thrombocythemia [193,194].…”

Section: Hematological Diseasesmentioning

confidence: 99%

Risk Factors of Cerebral Vein and Sinus Thrombosis

Freitas

Bogousslavsky

2007

Handbook on Cerebral Venous Thrombosis

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The risk factors for deep venous thrombosis (and for cerebral vein and sinus thrombosis, CVST) differ from those for arterial disease. The risk factors for venous thrombosis are linked to the Virchow triad of stasis of the blood, changes in the vessel wall, and changes in the composition of the blood, especially the first and third of these. Risk factors are usually divided into acquired (e.g. surgery, trauma, pregnancy, puerperium, lupus anticoagulant, malignant disease, and female hormones) and genetic (congenital thrombophilia). However, the separation of genetic and acquired risk factors is somewhat artificial, since they have additive effects and venous thrombosis is often multifactorial. In this review, we discuss acquired risk factors for CVST. These include hormonal changes (e.g. oral contraceptives use, hormone replacement therapy, pregnancy and puerperium), mechanical precipitants (e.g. head trauma, jugular catheterization, surgery, lumbar puncture), local and generalized infections, cancer, acquired prothrombotic states (e.g. hyperhomocysteinemia, nephrotic syndrome), inflammatory diseases (e.g. vaculitis, intestinal inflammatory disease), hematological disorders, neurological diseases (e.g. dural arteriovenous malformations, spontaneous intracranial hypotension), drugs and other situations. However, only some conditions are consistently present in case series, while many appear only in anecdotal reports. Thus, in most situations, a causal link cannot be established. Determining a cause-and-effect relationship is essential for developing preventive, diagnostic, and therapeutic strategies. Therefore, further multicentered, case-controlled studies are crucial for better understanding the pathogenesis of CVST.

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Lateral sinus thrombosis and intracranial hypertension in essential thrombocythaemia.

Cited by 22 publications

References 2 publications

Clinical manifestations of essential thrombocythemia in young adults

Clinical manifestations of essential thrombocythemia in young adults

Cranial Venous Outflow Obstruction and Pseudotumor Cerebri Syndrome

Risk Factors of Cerebral Vein and Sinus Thrombosis

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