Lateral spread of dose distribution by therapeutic proton beams in liquid water

Abril, Isabel; Vera, Pablo de; García-Molina, Rafael; Kyriakou, Ioanna; Emfietzoglou, Dimitris

doi:10.1016/j.nimb.2014.11.100

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…Elaborated models can also provide energy distributions around an ion track in more specific conditions if needed [see e.g. (Friedland et al 2011(Friedland et al , 2017Abril et al 2015;Garcia-Molina et al 2009;Nikjoo et al 2006;Emfietzoglou et al 2004)]. As mentioned before, for a given particle with defined incident energy, LET is not constant along the track and several formula exist for different energy ranges (Farhataziz and Rodgers 1987), picked up by software such as SRIM to model the whole range of energy deposition of typical ions in a large domain of incident energy (Ziegler et al 2010).…”

Section: The Case Of High-let Radiationsmentioning

confidence: 99%

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

et al. 2019

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Background It is striking how chemists and biologists showed an interest for ionizing radiations very soon after their discovery by Roentgen and Becquerel, and initiated parallel developments of these new fields of research: radiation chemistry and radiobiology. Radiation chemistry deals with the chemical effects produced when materials are exposed to ionizing radiations and begun long before 1942 when it was formally named by Burton (Magee 1988). Early pioneering works were achieved by Curie and Debierne in 1901 by observing gas bubbling out of radium salt solutions, Giesel in 1902 (Giesel 1902), Ramsay in 1903, and the progress and enthusiasm persisted throughout the beginning of 20th century (Debierne 1914; Kernbaum 1909

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Section: The Case Of High-let Radiationsmentioning

confidence: 99%

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

et al. 2019

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“…As a result, it is crucial to consider the multiple elastic scattering of the proton beam since it results in a nonnegligible lateral spread around the Bragg peak and degrades the prediction of the position of the Bragg peak. 6) As described before in Sect. 2, the method used in our experiment to determine the beam deviation is to voxelized the water phantom with a series of small voxels, which allows us to detect the dose in any region of space.…”

Section: Resultsmentioning

confidence: 97%

“…4,5) Therefore, the use of proton beams is an accurate technique for external radiation therapy in which the preservation of organs close to the target and the sparing of vital structures far from the target are crucial due to the possibility of delivering large and uniform dose distributions. 6) To achieve high precision in proton therapy treatment planning, a fundamental need is to predict with accuracy the depth-dose curves of the proton, as well as its lateral distribution concerning the incident beam direction. Thus, for a better three-dimensional characterization of the dose distributions in the patient's organs, a precise description of how the incident projectile beam interacts with biological targets is required.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo simulation of the lateral spread for proton beams in voxelized water phantom using GEANT4 platform

Kaanouch

Krim

Ghazi

et al. 2023

Jpn. J. Appl. Phys.

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An evaluation of the lateral spread that the proton beams undergo during their interactions with a water phantom has been performed. We calculated and evaluated the dose distribution spatially deposed of protons acceleration up to energies between 70 and 215 MeV using a voxelized water phantom as a 3D detector. A 0.1 mm3 size precision voxel was used to detect and calculate the deposed energy and dose in any area of the water phantom using the GEANT4 platform based on the Monte-Carlo Method simulation. We find that, regardless of the initial proton energy, the lateral spread follows a parabolic pattern as a function of depth, and the ratio of the radius at the Bragg peak to the depth of the Bragg peak is around 2.8%. A good agreement has been found compared to other analytical models, simulation methods, and especially to experimental data.

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“…where ) is the root mean square (rms) scattering angle of the Gaussian distribution. Abril et al (2015) showed that the rms width of the distribution varies parabolically with depth z:…”

Section: Journal Of Young Investigators Researchmentioning

confidence: 99%

Optimal Targeting of a Tumor through Proton Beam Therapy

Pant¹,

Campbell²

2020

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the prostate, esophagus, lung and liver. A large number of pediatric patients with central nervous system (CNS) tumors also benefit from PBT (Gondi et al., 2016). Protons interact with matter in three different ways: interactions with atomic electrons, interactions with the atomic nucleus, and interactions with the atom as a whole (Verhey et al., 1998). Protons that interact with the nucleus may produce Bremsstrahlung radiation, but this occurs so infrequently that its effects are negligible. There is also the possibility that protons will collide with an atom and produce secondary protons, neutrons, or excited nuclei, although these interactions are also rare. Protons primarily lose kinetic energy as they traverse matter via inelastic Coulombic interactions with atomic orbital electrons, which also deflect the proton trajectory (Newhauser and Zhang, 2015). The deflection due to a single interaction is generally quite small as the mass of a proton is much larger than that of an electron. However, the cumulative effect of many such interactions can be significant. The most complete theory of multiple Coulombic scattering was proposed by Molière (1947). Many simplifications of this theory have been proposed, although this simplicity often reduces the accuracy in modeling Coulombic scattering at large angles. Gottschalk et al. (1993) approximated Molière's theory to take the form of a Gaussian function, assuming the small angle approximation in which sin(θ)≈θ: (1)

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Lateral spread of dose distribution by therapeutic proton beams in liquid water

Cited by 7 publications

References 26 publications

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

Importance of radiolytic reactions during high-LET irradiation modalities: LET effect, role of O2 and radiosensitization by nanoparticles

Monte Carlo simulation of the lateral spread for proton beams in voxelized water phantom using GEANT4 platform

Optimal Targeting of a Tumor through Proton Beam Therapy

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