Lateral static overload on immediately restored implants decreases the osteocyte index in peri-implant bone: a secondary analysis of a pre-clinical study in dogs

Calais, Celson Domingos de; Bordin, Dimorvan; Piattelli, Adriano; Iezzi, Giovanna; Negretto, Alexandre; Shibli, Jamil Awad

doi:10.1007/s00784-020-03662-1

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Another index which has been utilized in histomorphometry to assess outcomes of regenerated bone is the Osteocyte index (OI), in particular when investigating the bone response to functional loading. Most studies where OI was investigated related this index to different dental implant placement and loading patterns 52–56 . As the histological samples in this study were harvested before implant placement, the OI, albeit useful, might have been of lesser indication.…”

Section: Discussionmentioning

confidence: 97%

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Gene expression, micro‐CT and histomorphometrical analysis of sinus floor augmentation with biphasic calcium phosphate and deproteinized bovine bone mineral: A randomized controlled clinical trial

Arunjaroensuk,

Nampuksa,

Monmaturapoj

et al. 2024

Clin Implant Dent Rel Res

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AimsThe aim of this randomized controlled clinical trial was to compare the gene expression, micro‐CT, histomorphometrical analysis between biphasic calcium phosphate (BCP) of 70/30 ratio and deproteinized bovine bone mineral (DBBM) in sinus augmentation.Materials and MethodsTwenty‐four patients in need for sinus floor augmentation through lateral approach were randomized into BCP 70/30 ratio or DBBM. After at least 6 months of healing, a total of 24 bone specimens were collected from the entire height of the augmented bone at the area of implant placement and underwent micro‐CT, histomorphometric and gene expression analysis. The 12 bone specimens of BCP 70/30 ratio were equally allocated to micro‐CT and histologic analysis (test group, n = 6) and gene expression analysis (test group, n = 6). Similarly, the 12 bone specimens of DBBM were also allocated to micro‐CT and histologic analysis (control group, n = 6) and gene expression analysis (control group, n = 6). The newly formed bone, remaining graft materials and relative change in gene expression of four target genes were assessed.ResultsThe micro‐CT results showed no statistically significant difference in the ratio of bone volume to total volume (BV/TV ratio) for the two groups (BCP 41.51% vs. DBBM 40.97%) and the same was true for residual graft material to total volume (GV/TV ratio, BCP 9.97% vs. DBBM 14.41%). Similarly, no significant difference was shown in the histological analysis in terms of bone formation, (BCP 31.43% vs. DBBM was 30.09%) and residual graft area (DBBM 40.76% vs. BCP 45.06%). With regards to gene expression, the level of ALP was lower in both groups of bone grafted specimens compared with the native bone. On the contrary, the level of OSX, IL‐1B and TRAP was higher in augmented bone of both groups compared with the native bone. However, the relative difference in all gene expressions between BCP and DBBM group was not significant.ConclusionsThe BCP, HA/β‐TCP ratio of 70/30 presented similar histological and micro‐CT outcomes in terms of new bone formation and residual graft particles with DBBM. The gene expression analysis revealed different gene expression patterns between augmented and native bone, but showed no significant difference between the two biomaterials.

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Section: Discussionmentioning

confidence: 97%

“…Most studies where OI was investigated related this index to different dental implant placement and loading patterns. [52][53][54][55][56] As the histological samples in this study were harvested before implant placement, the OI, albeit useful, might have been of lesser indication.…”

Section: Groupmentioning

confidence: 99%

Gene expression, micro‐CT and histomorphometrical analysis of sinus floor augmentation with biphasic calcium phosphate and deproteinized bovine bone mineral: A randomized controlled clinical trial

Arunjaroensuk,

Nampuksa,

Monmaturapoj

et al. 2024

Clin Implant Dent Rel Res

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“…In addition, several studies have focused particular attention on the implants’ osteocyte index. The presence of osteocytes is an index of bone reactivity [ 28 , 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Guided Bone Regeneration with Occlusive Titanium Barrier: A Case Report and Clinical Considerations

Milillo¹,

Petruzzi

2023

Biomimetics

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The need to obtain adequate bone volumes for prosthetic rehabilitation supported by implants, using different techniques and materials, represents an urgent need in modern dentistry. We report a case regarding the management of implant-prosthetic rehabilitation of the first and second upper right molars, in which no less than 4 mm of crestal bone remained to insert two implants. Regeneration of the residual bone was previously performed using a customized titanium barrier and a filler of a blood clot with tricalcium beta phosphate. The bone gain (3 mm) was evaluated by comparing CBCT images, while the implant stability (mean 70) was assessed with the ISQ measurement. A regenerated bone sample was taken for histological analysis. Guided bone regeneration obtained with a titanium barrier and blood clot allowed for the insertion of stable implants in a mature bone without heterologous material.

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“…Research connects the OI with the bone response to functional loading, as the osteocyte is perceived to be a critical link in the mechanosensitive biological response and respective bone remodeling 37 . Studies investigating with OI in the proximity of implants with different loading patterns have identified potential differences in the response to adverse loading 38 . However, as the histological section in this study was harvested before the implant placement and thus any loading of the bone, the OI might have not been of primary relevance.…”

Section: Discussionmentioning

confidence: 99%

“…37 Studies investigating with OI in the proximity of implants with different loading patterns have identified potential differences in the response to adverse loading. 38 However, as the histological section in this study was harvested before the implant placement and thus any loading of the bone, the OI might have not been of primary relevance. In future studies, it might be interesting to follow this parameter, too, in particular in relation to bone remodeling after early loading.…”

Section: Clinical Evaluationmentioning

confidence: 99%

The impact of deproteinized bovine bone particle size on histological and clinical bone healing outcomes in the augmented sinus: A randomized controlled clinical trial

Kamolratanakul

Mattheos

Yodsanga

et al. 2022

Clin Implant Dent Rel Res

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Objective: The effect of different deproteinized bovine bone mineral (DBBM) particle sizes on bone healing in maxillary sinus floor augmentation remains unclear. This study compared the newly formed tissue and angiogenesis-related bone healing after sinus floor augmentation using large or small DBBM particles.Materials and Methods: Overall 32 patients were randomly divided into two groups using either large (1-2 mm) or small (0.25-1 mm) DBBM particles for sinus floor augmentation. After 6 months, the mineralized tissue volume was calculated using micro-computed tomography (micro-CT) analysis. The newly formed tissue composition was histomorphometrically analyzed. Angiogenesis was also examined by means of vascular endothelial growth factor (VEGF) expression. Implant failure and marginal bone loss were measured at a 1-year follow-up. Statistical analysis was performed using independent samples t-test.Results: Micro-CT analysis demonstrated that grafting with large particles resulted in higher bone volume (6.99 ± 2.72 mm 3 , p = 0.002) and Bone Volume/Tissue Volume (0.25 ± 0.1, p = 0.03) compared with small particles (3.76 ± 1.83 mm 3 and 0.14 ± 0.13, respectively). Small particles showed higher non-mineralized tissue volume (26.31 mm 3 ) compared with large particle group (17.4 ± 5.34 mm 3 ) with p = 0.001. The histological data revealed significantly higher area of newly formed bone (32.15% ± 14.04% for the large particle and 15.99% ± 14.12% for the small particle groups, p = 0.004). Likewise, non-mineralized tissue was significantly greater in the small particle group (66.48% ± 20.97%) compared with the large particle group (44.36%, p = 0.016). Moreover, use of large particles resulted in a significantly higher VEGF staining intensity score and VEFG positive cells. No implant failure was recorded in both groups, while no difference was found in terms of marginal bone loss at the 1-year follow-up.Conclusions: Sinus floor augmentation using large DBBM particles resulted in more angiogenesis expression, higher bone volume, and new bone formation at 6 months after sinus augmentation. However, clinical outcomes with regards to implant placement were similar in both groups.

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Lateral static overload on immediately restored implants decreases the osteocyte index in peri-implant bone: a secondary analysis of a pre-clinical study in dogs

Cited by 6 publications

References 31 publications

Gene expression, micro‐CT and histomorphometrical analysis of sinus floor augmentation with biphasic calcium phosphate and deproteinized bovine bone mineral: A randomized controlled clinical trial

Gene expression, micro‐CT and histomorphometrical analysis of sinus floor augmentation with biphasic calcium phosphate and deproteinized bovine bone mineral: A randomized controlled clinical trial

Guided Bone Regeneration with Occlusive Titanium Barrier: A Case Report and Clinical Considerations

The impact of deproteinized bovine bone particle size on histological and clinical bone healing outcomes in the augmented sinus: A randomized controlled clinical trial

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