We theoretically study the inelastic scattering rate and the carrier mean free path for energetic hot electrons in graphene, including both electron-electron and electron-phonon interactions. Taking account of optical phonon emission and electron-electron scattering, we find that the inelastic scattering time τ ∼ 10 −2 − 10 −1 ps and the mean free path l ∼ 10 − 10 2 nm for electron densities n = 10 12 − 10 13 cm −2 . In particular, we find that the mean free path exhibits a finite jump at the phonon energy 200 meV due to electron-phonon interaction. Our results are directly applicable to device structures where ballistic transport is relevant with inelastic scattering dominating over elastic scattering.The existence [1] of gated two-dimensional (2D) graphene layers, where carrier transport controlled by an external gate has become possible [2], provides the exciting possibility of novel high-speed electronic device structures [3] utilizing the high graphene carrier mobility [2,4]. Such fast graphene devices would work in the ballistic transport regime, where carrier mobility limited by elastic scattering, is essentially irrelevant (i.e. l e > l, with l e , l, being respectively the elastic and the inelastic carrier mean free path), and what matters is the inelastic scattering due to electron-electron and electron-phonon interactions. Such ballistic devices for ultrafast applications can only work if the relevant device dimensions are smaller than the inelastic mean free path l, and the speed of this device is limited by the inelastic scattering time τ (< τ e , where τ e is the elastic relaxation time). In currently available high-mobility (> 20, 000 cm 2 /Vs) graphene samples, l e (τ e ) 10 3 nm (1 ps), and therefore, inelastic scattering will dominate device operations for length (time) scales below 10 3 nm (1 ps).In this Letter, we calculate the inelastic mean free path (l) and the corresponding inelastic scattering rate τ −1 in graphene limited by electron-electron and electronphonon interactions. Our study is motivated by electron transport in the hot electron transistor device structure which is so designed as to allow electrons to traverse the base region ballistically. In such a device scheme, highly energetic electrons are injected in the emitter region which then travel through the base region ballistically before reaching the collector region. The fraction of electrons α that reach the collector goes as α ∼ e −d/l , where d is the width of the base region. The mean free path is given by l = vτ , where v is the Fermi velocity of electron and τ is the inelastic scattering time, which, in general, is a strong function of the injected energy of electrons and the electron density in the base region.We consider two principal mechanisms contributing to inelastic scattering arising from many-body interactions: (1) absorption or emission of optical phonons by electrons due to electron-phonon (e-ph) interaction; (2) exchangecorrelation effects induced by electron-electron (e-e) interaction. For the e-ph interact...