2021
DOI: 10.1038/s41531-021-00209-3
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Lateralized effects of deep brain stimulation in Parkinson’s disease: evidence and controversies

Abstract: The bilateral effects of deep brain stimulation (DBS) on motor and non-motor symptoms of Parkinson’s disease (PD) have been extensively studied and reviewed. However, the unilateral effects—in particular, the potential lateralized effects of left- versus right-sided DBS—have not been adequately recognized or studied. Here we summarized the current evidence and controversies in the literature regarding the lateralized effects of DBS on motor and non-motor outcomes in PD patients. Publications in English languag… Show more

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Cited by 15 publications
(10 citation statements)
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References 68 publications
(137 reference statements)
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“…Although the on-medication overall motor performance remained comparable between the initial GPi DBS and the rescue STN DBS, the latter substantially reduced the anti-parkinsonian medication. The clinically relevant improvement provided by rescue STN DBS was associated with an insignificant decline in speech performance, which is consistent with the current literature (Phokaewvarangkul et al, 2019 ; Lin et al, 2021 ).…”
Section: Discussionsupporting
confidence: 92%
“…Although the on-medication overall motor performance remained comparable between the initial GPi DBS and the rescue STN DBS, the latter substantially reduced the anti-parkinsonian medication. The clinically relevant improvement provided by rescue STN DBS was associated with an insignificant decline in speech performance, which is consistent with the current literature (Phokaewvarangkul et al, 2019 ; Lin et al, 2021 ).…”
Section: Discussionsupporting
confidence: 92%
“…Our findings demonstrate that these potential cognitive phenotypes likely interact differentially with unilateral STN DBS. The magnitude of verbal fluency declines following unilateral left STN DBS in our sample are compatible with published declines following bilateral DBS 10,41,42 , and with prior observations that have linked left STN lead location with changes in verbal fluency output 41 . Collectively, these findings suggest that the left hemisphere lead likely drives most of the observed verbal fluency declines following bilateral surgeries.…”
Section: Discussionsupporting
confidence: 91%
“…Neuromodulation through brain stimulation involves the application of electrical currents, magnetic fields, or ultrasound waves to either excite or inhibit neuronal activity by modulating the activity of specific brain regions. Brain stimulation techniques can be used as an effective non-pharmacological approach for the treatment of diseases including depression [ 1 ], Alzheimer's [ 2 ], Parkinson's [ 3 ], and addiction [ 4 ]. This approach can be categorized into transcranial magnetic stimulation (TMS) [ 5 ], transcranial electrical stimulation (tES) [ 6 ], transcranial ultrasound stimulation (TUS) [ 7 ], and invasive deep brain stimulation (DBS) [ 8 ].…”
Section: Introductionmentioning
confidence: 99%