Lateralized P3 deficit in schizotypal personality disorder

Niznikiewicz, Margaret; Voglmaier, Martina M.; Shenton, Martha E.; Dickey, Chandlee C.; Seidman, Larry J.; Teh, EngKeat; Rhoads, Richard Van; McCarley, Robert W.

doi:10.1016/s0006-3223(00)00938-0

Cited by 26 publications

(17 citation statements)

References 24 publications

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“…For example, less P50 suppression, a measure of sensory gating, has been found in SPD individuals (Cadenhead et al, 2000; 2002). A modestly reduced P300 has been also reported in SPD (Niznikiewicz et al, 2000; Salisbury et al, 1996). Reduced P300 has been found in first episode schizophrenia thus bolstering the notion that disease related changes might be occurring before the first episode and that their first appearance may be documented in less affected populations such as prodromal individuals and, likely, in SPD, even though at a reduced level.…”

Section: Discussionmentioning

confidence: 73%

Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder

Niznikiewicz

Spencer

Dickey

et al. 2009

Schizophrenia Research

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Background The goal of the study was to examine mismatch negativity (MMN) in schizotypal personality disorder (SPD) individuals. Abnormal MMN has been a consistent finding in chronic schizophrenia and there are also have been reports of reduced duration MMN in first episode schizophrenia patients (Umbricht & Krljes, 2005), with some studies finding no pitch MMN amplitude differences (Salisbury et al., 2002) while others reporting a modest reduction (Umbricht et al., 2006) in recent onset schizophrenia patients. To our knowledge no reports exist of MMN in SPD individuals. Methods Twenty six normal (14 females) control and 23 SPD (12 females) individuals were tested using the pitch MMN paradigm. Normal control (NC) and SPD individuals were recruited from the general population and assessed using DSM-IV. SPD individuals were included if they met 5 or more criteria for SPD disorder. The subjects listened to 2000 frequent 1 kHz pure tones and 100 rare 1.2 kHz pure tones while reading a magazine article. MMN was measured from a difference waveform within the latency window of 175–276 msec. Results Reduced MMN amplitude was found in SPD relative to NC subjects (p< 0.045). Conclusions These results point to potential differences between SPD and schizophrenia, where no reduction in MMN was found in most studies of first episode patients.

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Section: Discussionmentioning

confidence: 73%

Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder

Niznikiewicz

Spencer

Dickey

et al. 2009

Schizophrenia Research

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“…This results in smaller effect sizes in SPD samples for endophenotypic measures. For example, one of the most robust ERP biomarkers of schizophrenia, auditory P300 amplitude reduction, appears to be less reliably affected in SPD: Previous studies have shown moderate (Mannan et al, 2001), mild (Niznikiewicz et al, 2000) or non-significant reductions of auditory P300 amplitude (Salisbury et al, 1996; Shin et al, 2010; Trestman et al, 1996). Moreover, familial SPD participants have been reported to be more impaired than non-familial SPD participants on a variety of schizophrenia biomarkers, including smooth pursuit eye movement abnormalities (Thaker et al, 1996), grammatical comprehension errors (Condray & Steinhauer, 1992) and P300 amplitude (Kimble et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder

Rass

Forsyth

Krishnan

et al. 2012

Schizophrenia Research

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The power and phase synchronization of the auditory steady state response (ASSR) at 40 Hz stimulation are usually reduced in schizophrenia (SZ). The sensitivity of the 40 Hz ASSR to schizophrenia spectrum phenotypes, such as schizotypal personality disorder (SPD), or to familial risk has been less well characterized. We compared the ASSR of patients with SZ, persons with schizotypal personality disorder, first degree relatives of patients with SZ, and healthy control participants. ASSRs were obtained to 20, 30, 40 and 50 Hz click trains, and assessed using measures of power (mean trial power or MTP) and phase consistency (phase locking factor or PLF). The MTP to 40 Hz stimulation was reduced in relatives, and there was a trend for MTP reduction in SZ. The 40 Hz ASSR was not reduced in SPD participants. PLF did not differ among groups. These data suggest the 40 Hz ASSR is sensitive to familial risk factors associated with schizophrenia.

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“…Furthermore, smaller left posterior temporal P300 amplitudes had been found in several groups at risk for psychosis: in anhedonic probands (Simons, 1982), in questionnaire-identified subjects with schizotypal personality (Klein et al, 1999), and in patients with schizotypal personality disorder (Salisbury et al, 1996;Trestman et al, 1996;Niznikiewicz et al, 2000). These results from different high-risk groups suggest that left posterior temporal P300 deficits represent a general marker of susceptibility to schizophrenia.…”

Section: Is Left Temporoparietal P300 Amplitude a Vulnerability Marker?mentioning

confidence: 98%

Auditory P300 in individuals clinically at risk for psychosis

Frommann

Brinkmeyer

Ruhrmann

et al. 2008

International Journal of Psychophysiology

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Lateralized P3 deficit in schizotypal personality disorder

Cited by 26 publications

References 24 publications

Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder

Abnormal pitch mismatch negativity in individuals with schizotypal personality disorder

Auditory steady state response in the schizophrenia, first-degree relatives, and schizotypal personality disorder

Auditory P300 in individuals clinically at risk for psychosis

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