Latest Estimates of Survival Rates of the 24 Most Common Cancers in Adolescent and Young Adult Americans

Bleyer, Archie

doi:10.1089/jayao.2010.0005

Cited by 93 publications

(76 citation statements)

References 15 publications

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“…[1][2][3] More than 70,000 new cancers are diagnosed in patients age 15 to 39 years each year, approximately eight times the number of those diagnosed in children younger than 15 years of age. 1,4 Excluding homicide, suicide, and unintentional injury, cancer is the leading cause of death in the AYA population.…”

Section: Introductionmentioning

confidence: 99%

Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?

Parsons

Harlan

Seibel

et al. 2011

JCO

164

233

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A B S T R A C T PurposeBecause adolescent and young adult (AYA) patients with cancer have experienced variable improvement in survival over the past two decades, enhancing the quality and timeliness of cancer care in this population has emerged as a priority area. To identify current trends in AYA care, we examined patterns of clinical trial participation, time to treatment, and provider characteristics in a population-based sample of AYA patients with cancer. MethodsUsing the National Cancer Institute Patterns of Care Study, we used multivariate logistic regression to evaluate demographic and provider characteristics associated with clinical trial enrollment and time to treatment among 1,358 AYA patients with cancer (age 15 to 39 years) identified through the Surveillance, Epidemiology, and End Results Program. ResultsIn our study, 14% of patients age 15 to 39 years had enrolled onto a clinical trial; participation varied by type of cancer, with the highest participation in those diagnosed with acute lymphoblastic leukemia (37%) and sarcoma (32%). Multivariate analyses demonstrated that uninsured, older patients and those treated by nonpediatric oncologists were less likely to enroll onto clinical trials. Median time from pathologic confirmation to first treatment was 3 days, but this varied by race/ethnicity and cancer site. In multivariate analyses, advanced cancer stage and outpatient treatment alone were associated with longer time from pathologic confirmation to treatment. ConclusionOur study identified factors associated with low clinical trial participation in AYA patients with cancer. These findings support the continued need to improve access to clinical trials and innovative treatments for this population, which may ultimately translate into improved survival.

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Section: Introductionmentioning

confidence: 99%

Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?

Parsons

Harlan

Seibel

et al. 2011

JCO

164

233

View full text Add to dashboard Cite

show abstract

“…3 While the 5-year survival rates for some common young adult malignancies such as thyroid and testicular cancer exceed 80%, the survival rates for diseases such as leukemia remain less than 60%, with survival rates for some solid tumors even lower. 4 An emerging trend in the literature suggests that nonelderly adults are more likely to receive aggressive treatment in the last month of their life (chemotherapy, intensive care unit [ICU] admission, cardiopulmonary resuscitation [CPR], intubation, and mechanical ventilation), but much of what we know is based on Medicare utilization in adults over 65. [5][6][7][8][9][10] Nonelderly adults are also less likely to receive palliative and/or hospice services prior to death.…”

Section: Introductionmentioning

confidence: 99%

End-of-Life Care Characteristics for Young Adults with Cancer Who Die in the Hospital

Keim‐Malpass

Erickson

Malpass

2014

Journal of Palliative Medicine

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Background: Evidence suggests nonelderly adults with cancer are likely to receive aggressive treatment in their last month of life and less likely to receive hospice and/or palliative services. Young adults with cancer (18-39 years) are a unique population, and little is known about the characteristics of their end-of-life care trajectories when they die in the hospital. Objective: The purpose of this descriptive pilot study was to explore the characteristics of death among young adults with cancer who died in a tertiary academic hospital in order to elucidate their end-of-life trajectories. Methods: A retrospective chart review was conducted among hospitalized young adults with a primary cancer diagnosis who died in the hospital within a 10-year period. Study variables were abstracted for quantification and medical record notes were reviewed for validation. Results: A review of 61 patient records indicate that young adults commonly received cancer treatment within weeks of death and that do-not-resuscitate orders were frequently written only when death appeared imminent. Palliative care teams were frequently consulted for management of physical symptoms but often within days of death and most commonly on the day of death. Conclusions: Findings suggest palliative care was initiated late in the care trajectory for young adults with cancer who died in the hospital. This study highlights the need for further inquiry into end-of-life care for young adults with cancer so that interventions can be developed to meet the physical, emotional, social, and spiritual needs of this unique group of patients, their families, and friends.

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“…5 Less than half of the 24 most common AYA cancer diagnoses have a 5-year survival rate exceeding 80%. 6 Compared with survival trends among pediatric and older cancer populations, there has been limited progress in improving the survival rates of AYA cancers in recent decades.…”

Section: Introductionmentioning

confidence: 99%

A narrative review of the occurrence of posttraumatic stress responses in adolescent and young adult cancer survivors

Vuotto¹,

Perez²,

Krull³

et al. 2015

COAYA

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Adolescent and young adult cancer survivors may experience posttraumatic stress responses following cancer diagnosis or treatment. The current paper reviews 23 studies reporting the occurrence of posttraumatic stress symptoms (PTSS) and posttraumatic stress disorder (PTSD), and associated predictors of these outcomes in adolescent and young adult cancer survivors. Results indicate considerable variability among prevalence estimates of PTSD (0%-34.8%) and PTSS (4.4%-78%). Measurement inconsistencies limiting the ascertainment of reliable prevalence and risk estimates are discussed in the context of the reviewed literature. Specifically, differences in assessment measures utilized, the timing of assessment relative to diagnosis, the criteria used to define the outcome, and identification of the precipitating traumatic event may account for discrepancies in prevalence and risk estimates across studies. The application of specific PTSD diagnostic criteria to a survivorship population is discussed. Empirically supported interventions utilizing cognitive behavioral therapy approaches for the treatment of PTSS in adolescent and young adult cancer survivors are identified.

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Latest Estimates of Survival Rates of the 24 Most Common Cancers in Adolescent and Young Adult Americans

Cited by 93 publications

References 15 publications

Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?

Clinical Trial Participation and Time to Treatment Among Adolescents and Young Adults With Cancer: Does Age at Diagnosis or Insurance Make a Difference?

End-of-Life Care Characteristics for Young Adults with Cancer Who Die in the Hospital

A narrative review of the occurrence of posttraumatic stress responses in adolescent and young adult cancer survivors

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