Latest update of odontogenic tumors in Alexandria University, Egypt: A 5-year retrospective study using WHO 2017 classification

Noureldin, Marwa; Ragab, Hala R.

doi:10.21608/edj.2019.72229

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…2019. [23,31] Aging may predispose to cancer due to the disturbances in immune and endocrine systems. It is also associated with variations in molecular, cellular and systemic levels that influence carcinogenesis and subsequent cancer growth.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

Hasan

Nagdy

Ibrahim

2021

JST

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Background: Ameloblastoma is a common benign aggressive odontogenic tumor with a tendency for high recurrence rate. Ameloblastic Carcinoma is the malignant counterpart of Ameloblastoma. However, they are usually difficult to be distinguished from one another. Therefore, using Immunohistochemical markers might be beneficial for diagnosing them accurately.Objective: Evaluation of SOX2 and GPC3 expressions as well as evaluating their roles in the tumorigenesis and the biological behavior of Ameloblastoma and Ameloblastic Carcinoma.Methods: Tissue samples are composed of 34 archived histopathologically confirmed cases of (19 Conventional Ameloblastomas, and 15 Ameloblatic Carcinomas). Sections were subjected to Immunohistochemical staining according to a standard protocol by applying antibodies to SOX2, and GPC3.Results: SOX2 and GPC3 expressions in recurrent Ameloblastoma were significantly higher than non- recurrent cases. Ameloblastic Carcinoma showed the highest immune-reactivity to SOX2 and GPC3 compared to the Conventional Ameloblastoma. Desmoplastic Ameloblastoma showed the highest scores of SOX2 and GPC3 compared to the other subtypes.Conclusions: SOX2 and GPC3 can be used as a panel for diagnosing the aggressive and the malignant odontogenic tumors accurately. Desmoplastic Ameloblastoma behaves more aggressively than other Conventional Ameloblastoma subtypes.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

Hasan

Nagdy

Ibrahim

2021

JST

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A comprehensive analysis of odontogenic tumors according to recent WHO (2022) classification: An institution-based retrospective study

Asnani,

Ali,

Odedra

et al. 2024

Journal of Oral and Maxillofacial Pathology

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Background: Odontogenic tumors constitute a rare group of lesions with diverse characteristics originating from tooth-forming tissues, primarily within the maxillofacial region. Variations in incidence across populations in India and with changes incorporated in successive World Health Organization (WHO) classifications, necessitate continued research to understand their epidemiology. Objective: This retrospective study aims to provide an extensive analysis of Odontogenic tumors reported in a dental institute in Gujarat, India, using the 5th edition of the WHO classification. The study also seeks to compare the findings with data from other regions. Methods: A retrospective analysis was conducted on archived histopathological records from the Oral Pathology department of our institute, spanning from 1966 to 2023. This analysis focused on demographic details, tumor types, and their distribution. The data were reclassified according to the WHO 5th edition and subjected to descriptive statistical analysis. Results: Among 10,907 biopsies, 501 cases (4.6%) were diagnosed as Odontogenic tumors, with 97.6% being benign. Benign epithelial tumors, predominantly Ameloblastoma (68.9%) was most common. Supporting their rare occurrence malignant cases included Ameloblastic carcinoma (2.2%) and Clear Cell Odontogenic Carcinoma (0.2%). An overall male predominance (51.7%) was noted, with female dominance in Adenomatoid Odontogenic tumor (60%), Cemento-Ossifying Fibroma (62.5%), Odontogenic fibroma (91%), and Odontogenic Myxoma (66.7%). Most cases occurred in the third decade (27.1%), with a notable mandibular predominance (78%). Conclusion: The findings contribute to the understanding of Odontogenic tumors epidemiology, emphasizing the importance of further regional studies and adapting to evolving classifications for accurate assessments and cross-population comparisons.

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Latest update of odontogenic tumors in Alexandria University, Egypt: A 5-year retrospective study using WHO 2017 classification

Cited by 2 publications

References 46 publications

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

Prognostic significance of SOX2 and GPC3 in Ameloblastoma and its malignant counterpart (Ameloblastic Carcinoma)

A comprehensive analysis of odontogenic tumors according to recent WHO (2022) classification: An institution-based retrospective study

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