Latex Gloves with a Lower Protein Content Reduce Bronchial Reactions in Subjects with Occupational Asthma Caused by Latex

Abstract

Latex gloves have been documented as causing rhinitis and asthma. Using inhalation challenges, we evaluated the bronchial response to hypoallergenic gloves in eight health care workers with latex-induced asthma. The subjects were exposed to the powdered latex gloves causing asthma at work and various brands of gloves with a lower protein content, either low-powdered, nonpowdered, or powdered. Exposure to hypoallergenic gloves resulted in the absence (in six subjects) or a significant reduction (in two subjects) of bronchial response. The effects of repeated exposure to hypoallergenic gloves was assessed in two subjects who did not demonstrate changes in peak expiratory flow rates and nonspecific bronchial responsiveness to histamine. This study on a limited number of patients suggests that the use of hypoallergenic gloves could be an effective means of reducing the risk of asthmatic reactions in health care workers with latex-induced asthma when complete avoidance cannot be achieved. The long-term effect of exposure as well as the widespread use of hypoallergenic gloves warrant further investigation on larger cohorts of subjects.

Clinical Value of Conjunctival Allergen Challenge in Diagnosing Allergic Conjunctivitis Related to Latex

“…They applied latex glove extracts in increasing concentrations and assessed the clinical response and spirometry. Currently, this test may be performed with the use of atomized latex extract [23] and is considered useful for the diagnosis of occupational allergy in particular working conditions [23,24]. …”

Different latex aeroallergen size distributions between powdered surgical and examination gloves: Significance for environmental avoidance

“…Many hospitals have worked toward the goal of a latex-safe environment by attempting to eliminate all powdered and in some cases nonpowdered latex medical gloves. [4][5][6]12,13 Although most have been successful with conversion of powdered nonsterile latex examination gloves to synthetic alternatives, it has been more difficult to get surgeons to convert from powdered sterile surgical gloves to nonpowdered or synthetic alternatives. 14 The cited reasons for this include barrier protein concerns, leakage rates, undesirable tactile characteristics, and cost.…”

Occupational Rhinitis

“…OR has been well-described in health care workers [1, [17][18][19]. Natural rubber latex (NRL) and psyllium are commonly associated with OR in health care workers.…”

“…Studies have shown that strategies to reduce occupational exposure have successfully decreased OR symptoms in cases of OR caused by NRL [18] and proteolytic enzymes [37]. Steps to modify the workplace could include providing adequate ventilation and aspiration of pollutants, using less hazardous materials, and creating closed-circuit manufacturing processes.…”