Prefixed verbs in Latin may take an argument in the dative case, interpreted as the ground of the spatial relation codified by the preverb. This phenomenon is constrained by the semantics of that spatial relation: while preverbs encoding a location, a goal, or a source of motion generally accept the dative argument, preverbs encoding a route do not. I propose a syntactic analysis of this phenomenon, framed within the Spanning framework. I assume an analysis of the spatial dative as an applied argument interpreted as a possessor of the final location of motion. Developing a configurational theory of spatial relations, I show how only the syntax-semantics of the preverbs interpreted as encoding a location, be this final (a goal), initial (a source), or unrelated to motion (a static location), is compatible with the projection of an Appl(icative)P integrating the dative argument. By the same token, pure route preverbs, involving a path but not a location, are correctly predicted to disallow the projection of ApplP, and hence the spatial dative.