Launaea taraxacifolia leaf partitions ameliorate alloxan-induced pathophysiological complications via antioxidant mechanisms in diabetic rats

Abstract

Launaea taraxacifolia (Wild.) Amin ex. Jeffery belongs to family Asteracaea. The plant is used for treatment of diseases and eaten as vegetable in Nigeria. This study investigated the ameliorative potentials of L . taraxacifolia leaf partitions in alloxan induced diabetic complications. Male Albino rats were divided into eleven groups of five rats each. Diabetes was induced following intraperitoneal administration of 150 mg/kg alloxan monohydrate and was treated with 200 and 300 mg/kg of each partitioned fractions. Hyperglycemia was reversed in all treated rats within seven days of treatments. Rats treated with the partitions showed significant increase in hematological parameters compared with diabetic control. N-hexane fraction had the best overall effect against oxidative stress particularly on heart and pancreas reduced glutathione (GSH), superoxide dismutase (SOD) and kidney glutathione S-transferase (GST) activities. The various degrees of degeneration observed in the kidney, liver, pancreas and heart of the untreated diabetic rats were milder in rats treated with partitions. The results therefore revealed the ameliorative potentials of the partitioned fractions of L. taraxacifolia leaf extract against diabetes mellitus complications via activation of the antioxidant enzymes.

Chemical Profile of Launaea nudicaulis Ethanolic Extract and Its Antidiabetic Effect in Streptozotocin-Induced Rats

“…Moreover, the L. nudicaulis extract was found to improve the renal functions including that deduced via enhancement of creatinine, uric acid, and urea compared with glibenclamide. All these data are in full agreement with Gbadmosi, et al’s results [ 61 ]. All the results revealed to the capability of the extract to manage the serum insulin levels along with the weekly body weight.…”

“…The reduction of the blood glucose levels via the effect of the extract induction might be ascribed to its capacity to increase glucose absorption as well as the decreasing of the glucagon releasing (11). All these effects were documented from several medicinal plants including some Launaea plants such as L. taraxacifolia and L. cornuta [61]. Also, the inhibitory action of the extract of α-glucosidase might be one of the possible mechanismatic pathways that increase the polysaccharide conversion to simple sugars [62].…”

“…The polyphenolics in L. nudicaulis including phenolic acids and flavonoids, were reported to have potential role in the inhibition and/or controlling of diabetes via several pathways such as (i) pancreatic islet β-cell protection, (ii) inhibition and/or decrease of βcell apoptosis, (iii) increased β-cell proliferation, (iv) oxidative stress reduction, (v) insulin secretion activation, (vi) digestive enzymes and glucose absorption inhibition, and other effects [70]. Additionally, the roles of these phenolic compounds in the enhancement of diabetic complications were reported [61] and help account for the protective effects observed in this study. The simple phenolic acids i.e., gallic, caffeic, and p-coumaric acids and their derivatives were described as significant hypoglycemic agents [78,79], which act through multiple mechanisms i.e., inhibition of gluconeogenesis, increasing of C-peptide and insulin secretion and glycolysis, enhancing of the functions of liver and renal in addition of others [70].…”

Evaluation of Antidiabetic Effect of Luteolin in STZ Induced Diabetic Rats: Molecular Docking, Molecular Dynamics, In Vitro and In Vivo Studies

“…This was further substantiated by histology findings, which showed that diabetic groups displayed shrinkage, necrosis, and damaged β-cell populations; however, after administering LUT, these effects returned to normal. We found an interesting agreement between our findings and recently published reports [ 25 , 26 ].…”

“…The LUT treatment for diabetic rats possessed insulin-secretory effects like GLB [ 24 ]. These findings showed that LUT can reduce insulin resistance in diabetic animals [ 25 , 26 ]. This was further substantiated by histology findings, which showed that diabetic groups displayed shrinkage, necrosis, and damaged β-cell populations; however, after administering LUT, these effects returned to normal.…”