2018
DOI: 10.1021/acs.jproteome.8b00383
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Launching the C-HPP neXt-CP50 Pilot Project for Functional Characterization of Identified Proteins with No Known Function

Abstract: An important goal of the Human Proteome Organization (HUPO) Chromosome-Centric Human Proteome Project (C-HPP) is to correctly define the number of canonical protein encoded by their cognate open reading frames on each chromosome in the human genome. When identified with high confidence of protein evidence (PE) such proteins are termed PE1 proteins in the online database resource, neXtProt. However, proteins that have not been identified unequivocally at the protein level, but that have other evidence suggestiv… Show more

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Cited by 42 publications
(71 citation statements)
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“…The term "proteoform" encompasses all the various forms of proteins that result from molecular or cellular modifications (1). Given their important biological roles, proteoforms have been included in the list of proteome parts examined in the global Chromosome-centric Human Proteome Project (C-HPP) 1 (2)(3)(4). Fusion proteoforms are protein products that are translated from the fusion transcripts that form when two different transcripts join because of chromosomal translocation, structural variation, or trans-splicing.…”
Section: In Addition Our Prediction Results Indicate That Fusion Tramentioning
confidence: 99%
See 1 more Smart Citation
“…The term "proteoform" encompasses all the various forms of proteins that result from molecular or cellular modifications (1). Given their important biological roles, proteoforms have been included in the list of proteome parts examined in the global Chromosome-centric Human Proteome Project (C-HPP) 1 (2)(3)(4). Fusion proteoforms are protein products that are translated from the fusion transcripts that form when two different transcripts join because of chromosomal translocation, structural variation, or trans-splicing.…”
Section: In Addition Our Prediction Results Indicate That Fusion Tramentioning
confidence: 99%
“…FAM133B: CDK6) in Jurkat T cells. As the scope of the global C-HPP is extended to mapping human proteoforms (3,4), FusionPro may contribute to this global project by deepening the pool of proteomes, which could provide potential biomarkers and drug targets for human cancers.…”
Section: Discussionmentioning
confidence: 99%
“…(4) Whereas the annotation of rice proteins and identification of MPs are important steps to enhance our understanding of rice proteome, the ''parts list'' alone does not inform function. The next step should be functional characterization of identified proteins with no known function using a variety of experimental approaches (Paik et al, 2018). (5) Finally, a systematic global effort will be necessary to identify yet-to-be-annotated rice proteins in biological samples that lack sufficient experimental evidence at the protein level for confident protein identification.…”
Section: Molecular Plantmentioning
confidence: 99%
“…Among the validated proteins (PE1), 1,254 are devoid of functional annotation, either predicted or experimental. These proteins, called uPE1, are now prioritized for characterization in the context of the recently launched HPP neXt-CP50 project [5]. Nearly all neXtProt entries have at least one single amino acid variant (SAAV) associated and 78% have at least one PTM associated.…”
Section: Introductionmentioning
confidence: 99%