Laurencin, a constituent from species

Irie, Toshi; Suzuki, Minoru; Masamune, Tadashi

doi:10.1016/s0040-4039(00)90038-8

Cited by 123 publications

(52 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other brominated compounds are a sesquiternoid (laurenterol) from Laurencia intermedia (10), and an acetylenic, heterocyclic compound, laurencin, from L. glandulifera (10). The principal phenol of P. lanosa has been characterized as 2,3-dibromobenzyl alcohol-4,5-disulfate, dipotassium salt (8).…”

Section: Bromophenols From Red Algae Bromophenols From Red Algaementioning

confidence: 99%

Bromophenols from Red Algae

Craigie¹,

Gruenig²

1967

Science

View full text Add to dashboard Cite

show abstract

Section: Bromophenols From Red Algae Bromophenols From Red Algaementioning

confidence: 99%

Bromophenols from Red Algae

Craigie¹,

Gruenig²

1967

Science

View full text Add to dashboard Cite

show abstract

“…The thalli are erect, forming dense tufts 4–20 cm high, brown-purple or violet-greenish in color [1]. The genus Laurencia [2] was recognized, since the first studies on natural products in the 1960s, as an important source of secondary metabolites, mainly halogenated compounds [3,4]. The secondary metabolites of Laurencia play a relevant ecological role as chemical defenses against bacterial colonization and infection [5-7].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic analysis of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta) and its microbiome

et al. 2012

View full text Add to dashboard Cite

BackgroundSeaweeds of the Laurencia genus have a broad geographic distribution and are largely recognized as important sources of secondary metabolites, mainly halogenated compounds exhibiting diverse potential pharmacological activities and relevant ecological role as anti-epibiosis. Host-microbe interaction is a driving force for co-evolution in the marine environment, but molecular studies of seaweed-associated microbial communities are still rare. Despite the large amount of research describing the chemical compositions of Laurencia species, the genetic knowledge regarding this genus is currently restricted to taxonomic markers and general genome features. In this work we analyze the transcriptomic profile of L. dendroidea J. Agardh, unveil the genes involved on the biosynthesis of terpenoid compounds in this seaweed and explore the interactions between this host and its associated microbiome.ResultsA total of 6 transcriptomes were obtained from specimens of L. dendroidea sampled in three different coastal locations of the Rio de Janeiro state. Functional annotations revealed predominantly basic cellular metabolic pathways. Bacteria was the dominant active group in the microbiome of L. dendroidea, standing out nitrogen fixing Cyanobacteria and aerobic heterotrophic Proteobacteria. The analysis of the relative contribution of each domain highlighted bacterial features related to glycolysis, lipid and polysaccharide breakdown, and also recognition of seaweed surface and establishment of biofilm. Eukaryotic transcripts, on the other hand, were associated with photosynthesis, synthesis of carbohydrate reserves, and defense mechanisms, including the biosynthesis of terpenoids through the mevalonate-independent pathway.ConclusionsThis work describes the first transcriptomic profile of the red seaweed L. dendroidea, increasing the knowledge about ESTs from the Florideophyceae algal class. Our data suggest an important role for L. dendroidea in the primary production of the holobiont and the role of Bacteria as consumers of organic matter and possibly also as nitrogen source. Furthermore, this seaweed expressed sequences related to terpene biosynthesis, including the complete mevalonate-independent pathway, which offers new possibilities for biotechnological applications using secondary metabolites from L. dendroidea.

show abstract

“…The first acetogenin halogenated C15 of red seaweed was isolated from the methanol extract of seaweed Laurencia glandulifera [107]. Halogenated aromatic polyketides can be classified as linear or cyclic, where the ring of the cyclic metabolites can range from five to twelve atoms in their structure [108].…”

Section: Red Seaweeds As a Source Of New Bioactive Prototypesmentioning

confidence: 99%

Seaweeds as Source of New Bioactive Prototypes

Nogueira¹,

Teixeira²

2016

Algae - Organisms for Imminent Biotechnology

View full text Add to dashboard Cite

Living organisms endowed with natural benefits have been used for millions of years in the medical practice. Seaweeds have been widely used around the world for the production of agar and food; however, the pharmaceutical industry has drawn attention to the activities of these natural products. In this chapter, we present some bioactive metabolites of the three phyla of seaweed (green, brown, and red algae) along with their potential for drug development.

show abstract

Laurencin, a constituent from species

Cited by 123 publications

References 1 publication

Bromophenols from Red Algae

Bromophenols from Red Algae

Transcriptomic analysis of the red seaweed Laurencia dendroidea (Florideophyceae, Rhodophyta) and its microbiome

Seaweeds as Source of New Bioactive Prototypes

Contact Info

Product

Resources

About