Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke

Shaheryar, Zaib Ali; Khan, Mahtab Ahmad; Hameed, Huma; Zaidi, Syed Awais Ali; Anjum, İrfan; Rahman, Muhammad Shafeeq Ur

doi:10.1016/j.ejphar.2023.175990

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…Since ACT was shown to have anti‐oxidant properties (Esnault et al., 2017 ; Millan‐Oropeza, Henry, et al., 2017 ), the deletion of the ACT cluster in M1141 is likely to be correlated with a raise of oxidative stress in this strain. Consistently, the lipidic compounds, lauric acid (CH₃–(CH₂)₁₀–COOH) and squalene, that are known to have anti‐oxidant properties (Shaheryar et al., 2023 ; Tian et al., 2023 ), were more abundant in M1141 than in M145 (Figures 3 and 4B ). Their biosynthesis might be triggered by the high oxidative stress resulting for the deletion of the ACT cluster and would thus compensate for the loss of ACT production.…”

Section: Resultsmentioning

confidence: 63%

Consequences of the deletion of the major specialized metabolite biosynthetic pathways of Streptomyces coelicolor on the metabolome and lipidome of this strain

Lejeune,

Abreu,

Guérard

et al. 2024

Microbial Biotechnology

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Chassis strains, derived from Streptomyces coelicolor M145, deleted for one or more of its four main specialized metabolites biosynthetic pathways (CPK, CDA, RED and ACT), in various combinations, were constructed for the heterologous expression of specialized metabolites biosynthetic pathways of various types and origins. To determine consequences of these deletions on the metabolism of the deleted strains comparative lipidomic and metabolomic analyses of these strains and of the original strain were carried out. These studies unexpectedly revealed that the deletion of the peptidic clusters, RED and/or CDA, in a strain deleted for the ACT cluster, resulted into a great increase in the triacylglycerol (TAG) content, whereas the deletion of polyketide clusters, ACT and CPK had no impact on TAG content. Low or high TAG content of the deleted strains was correlated with abundance or paucity in amino acids, respectively, reflecting high or low activity of oxidative metabolism. Hypotheses based on what is known on the bio‐activity and the nature of the precursors of these specialized metabolites are proposed to explain the unexpected consequences of the deletion of these pathways on the metabolism of the bacteria and on the efficiency of the deleted strains as chassis strains.

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Section: Resultsmentioning

confidence: 63%

Consequences of the deletion of the major specialized metabolite biosynthetic pathways of Streptomyces coelicolor on the metabolome and lipidome of this strain

Lejeune,

Abreu,

Guérard

et al. 2024

Microbial Biotechnology

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“…During reperfusion following an ischemic stroke, the reintroduction of blood flow causes a paradoxical surge in ROS production, exacerbating the injury ( Wu et al, 2021 ; Hong et al, 2023 ). Oxidative stress damages the BBB by directly affecting the endothelial cells, pericytes, and basal lamina as well as activating MMPs, and inflammatory pathways indirectly ( Shaheryar et al, 2023 , 2023 ; Wang S. et al, 2023 ). A compromised BBB increases the risk of hemorrhagic transformation and vasogenic edema.…”

Section: Oxidative Stressmentioning

confidence: 99%

Emerging diagnostic markers and therapeutic targets in post-stroke hemorrhagic transformation and brain edema

Yao,

Liu,

et al. 2023

Front. Mol. Neurosci.

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Stroke is a devastating condition that can lead to significant morbidity and mortality. The aftermath of a stroke, particularly hemorrhagic transformation (HT) and brain edema, can significantly impact the prognosis of patients. Early detection and effective management of these complications are crucial for improving outcomes in stroke patients. This review highlights the emerging diagnostic markers and therapeutic targets including claudin, occludin, zonula occluden, s100β, albumin, MMP-9, MMP-2, MMP-12, IL-1β, TNF-α, IL-6, IFN-γ, TGF-β, IL-10, IL-4, IL-13, MCP-1/CCL2, CXCL2, CXCL8, CXCL12, CCL5, CX3CL1, ICAM-1, VCAM-1, P-selectin, E-selectin, PECAM-1/CD31, JAMs, HMGB1, vWF, VEGF, ROS, NAC, and AQP4. The clinical significance and implications of these biomarkers were also discussed.

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Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke

Cited by 2 publications

References 36 publications

Consequences of the deletion of the major specialized metabolite biosynthetic pathways of Streptomyces coelicolor on the metabolome and lipidome of this strain

Consequences of the deletion of the major specialized metabolite biosynthetic pathways of Streptomyces coelicolor on the metabolome and lipidome of this strain

Emerging diagnostic markers and therapeutic targets in post-stroke hemorrhagic transformation and brain edema

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