Lavandula stoechas essential oil from Morocco as novel source of antileishmanial, antibacterial and antioxidant activities

Bouyahya, Abdelhakim; Et-Touys, Abdeslam; Abrini, Jamal; Talbaoui, Ahmed; Fellah, Hajiba; Bakri, Youssef; Dakka, Nadia

doi:10.1016/j.bcab.2017.10.003

Cited by 59 publications

(66 citation statements)

References 35 publications

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“…LAEO was active against all studied strains, so it can be considered as a new source of antibiotics. The obtained results are similar to previous studies concerning other Lavandula species …”

Section: Resultssupporting

confidence: 92%

“…is one of Lavandula species founded only in Morocco . The literature is rich in information concerning the biological activities of different Lavandula species, but all these studies have neither described the chemical composition nor the biological activities of this species. The goal of this study is to analyze and characterize the chemical constituents of LAEO, to evaluate its antibacterial activity against resistant bacteria, as well as to determine the relationships between some of selected terpenes descriptors with antibacterial activity in order to determine the compounds influencing the antibacterial activity of LAEO.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships

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Ouarhach

Rabie

et al. 2020

Chemistry & Biodiversity

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The genus Lavandula is known for its different uses in traditional medicine. This study is interested in the chemical composition of Lavandulapedunculata subsp.atlantica (BRAUN-BLANQ.) ROMO as well as evaluating its antibacterial potential against multi-resistant strains. The analysis of Lavandulaatlantica essential oil (LAEO) allows the identification of 47 components representing 93.6 % of all identified. The main constituent of LAEO was camphor (50.4 %), followed by fenchone (14.1 %) and camphene (5.6 %). The antibacterial assays revealed that LAEO was active against all the studied bacteria. A preliminary study of the relationship between certain terpenoids and antibacterial activity was also carried out in order to note the compound(s) that are responsible for LAEO's antibacterial activity. This study showed that the activity of the essential oil may be due to the presence of certain minor compounds such as carvone, considering the presence of the synergistic effect between the essential oil.

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Section: Resultssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships

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Ouarhach

Rabie

et al. 2020

Chemistry & Biodiversity

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“…MICs were determined using the broth micro‐dilution assay as described . Briefly, agar at 0.15% (w/v) was used as a stabilizer of the extract–water mixture and resazurin as a bacterial growth indicator.…”

Section: Methodsmentioning

confidence: 99%

“…The MBC corresponded to the lowest concentration of the molecule yielding negative subcultures after incubation at appropriate temperature for 24 h. It is determined in broth dilution tests by sub‐culturing 10 µL from negative wells on plate count agar (PCA) medium. All the tests were performed in triplicate …”

Section: Methodsmentioning

confidence: 99%

Concise synthesis and antibacterial evaluation of novel 3‐(1,4‐disubstituted‐1,2,3‐triazolyl)uridine nucleosides

Tachallait

Bouyahya

Talha

et al. 2018

Archiv der Pharmazie

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We report herein a simple and efficient synthesis of a new series of antibacterial uridine nucleosides. The strategy involved a sequential silylation/N-glycosylation/ N-propargylation procedure of uracil 1 for preparing the dipolarophile 5 in good yield.A series of novel uridine-[1,2,3]triazole nucleosides 6a-j were efficiently synthesized via the copper-catalyzed azide-alkyne cycloaddition (CuAAC) from dipolarophile 5 with different selected azides. The reactions were carried out under both conventional and ultrasonic irradiation conditions. In general, improvements were observed when reactions were carried out under sonication. Their antibacterial potential has been evaluated by means of a micro-dilution assay against either Gram-positive or Gram-negative bacteria. Compounds 6i and 6j have shown significant bactericidal activity against Staphylococcus aureus (MIC = 10 and 6 μM, respectively), and 6hagainst Escherichia coli (MIC = 8 μM). Moreover, antibacterial kinetic assays showed that 6i and 6j significantly reduced the S. aureus growth rate at the MIC concentration, after 6 h, compared to their deprotected analogs, 6k and 6l, respectively. Compound 6h also significantly reduced the growth of E. coli. These antibacterial effects may be related to the penetrating properties of these compounds, as revealed by the leakage of nucleic acids from the sensitive strains.

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“…In vitro studies showed that the lipoxygenase inhibitory and hyaluronidase inhibition effect and antibacterial activity of Lavandula spp. EO are related to its antioxidant activity [109,110,113,114].…”

Section: Antioxidant Activity Of Lavandula Spp Plantsmentioning

confidence: 99%

Plants of the Genus Lavandula: From Farm to Pharmacy

Salehi

Mnayer

Özçelik

et al. 2018

Natural Product Communications

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The Lavandula genus, belonging to the Lamiaceae, includes 39 species, with nearly 400 registered cultivars. Lavandula are worldwide plants that occur over the Mediterranean, Europe, North Africa, southwest Asia to southeast India. Lavandula plants have been used since ancient time to flavor and preserved food, to treat diseases including wound healing, sedative, antispasmodic, microbial and viral infections. Numerous researches have described the chemical composition and the primary components of lavender oils are the monoterpenoids (linalool, linalyl acetate, 1,8-cineole, β-ocimene, terpinen-4-ol, and camphor), sesquiterpenoids (β-caryophyllene and nerolidol) and other terpenoid compounds (e.g., perillyl alcohol). The high concentrations of linalyl acetate make them attractive in perfumery, flavoring, cosmetics and soap industries. Currently, data on the antimicrobial activity of lavender plants have been scientifically confirmed. Indeed, lavender essential oils possess wide spectra of biological activities such as antispasmodic, carminative, analgesic, sedative, hypotensive, antiseptic, antimicrobial, antifungal, antidiuretic and general tonic action. In addition, clinical studies support their uses as treatment of health conditions. However, further clinical studies are necessary to define the magnitude of the efficacy, mechanisms of action, optimal doses, long-term safety, and, potential side effects of lavender plants.

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Lavandula stoechas essential oil from Morocco as novel source of antileishmanial, antibacterial and antioxidant activities

Cited by 59 publications

References 35 publications

Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships

Evaluation of Antibacterial Activity of Lavandulapedunculata subsp. atlantica (Braun‐Blanq.) Romo Essential Oil and Selected Terpenoids against Resistant Bacteria Strains–Structure–Activity Relationships

Concise synthesis and antibacterial evaluation of novel 3‐(1,4‐disubstituted‐1,2,3‐triazolyl)uridine nucleosides

Plants of the Genus Lavandula: From Farm to Pharmacy

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