Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats

Sánchez-Vidaña, Dalinda Isabel; Po, Kevin Kai-ting; Fung, Timothy Kai-Hang; Chow, Jason Ka-Wing; Lau, Way Kwok‐Wai; So, Pui‐Kin; Lau, Benson Wui-Man; Tsang, Hector W.H.

doi:10.1016/j.neulet.2019.02.042

Cited by 65 publications

(34 citation statements)

References 90 publications

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“…We determined significant effects on neurite outgrowth in PC12 cells and on synapse density in primary hippocampal neurons. Sanchez-Vidana et al [29] found significantly enhanced neurogenesis after 14 day of treatment with lavender oil in the presence of cortisone treatment in the rat dentate gyrus compared to the cortisone-treated group. The neuroprotective effects of lavender oil were also investigated in a mouse model.…”

Section: Discussionmentioning

confidence: 98%

“…The standardized lavender oil preparation Silexan had been shown to possess preclinical [1][2][3] and clinical [4][5][6][7][8]29] anxiolytic properties. As possible anxiolytic mechanism of action, an inhibition of VOCCs has been postulated with some similarities but also differences to the anxiolytic drug pregabalin [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…Our findings regarding the antidepressant activity of Silexan in the FST test is supported by results from other groups, which re-ported antidepressant effects of lavender oil in the FST or the tail suspension test, another well-accepted behavioral paradigm to investigate antidepressant effects of drugs in mice. Sanchez-Vidana et al [29] investigated the antidepressant effects of lavender oil in rats using the FST. To induce depression-like behavior, the animals received cortisone for 14 days.…”

Section: Discussionmentioning

confidence: 99%

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Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties

et al. 2020

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Background Silexan, a special essential oil from flowering tops of lavandula angustifolia, is used to treat subsyndromal anxiety disorders. In a recent clinical trial, Silexan also showed antidepressant effects in patients suffering from mixed anxiety-depression (ICD-10 F41.2). Since preclinical data explaining antidepressant properties of Silexan are missing, we decided to investigate if Silexan also shows antidepressant-like effects in vitro as well as in vivo models. Methods We used the forced swimming test (FST) in rats as a simple behavioral test indicative of antidepressant activity in vivo. As environmental events and other risk factors contribute to depression through converging molecular and cellular mechanisms that disrupt neuronal function and morphology—resulting in dysfunction of the circuitry that is essential for mood regulation and cognitive function—we investigated the neurotrophic properties of Silexan in neuronal cell lines and primary hippocampal neurons. Results The antidepressant activity of Silexan (30 mg/kg BW) in the FST was comparable to the tricyclic antidepressant imipramine (20 mg/kg BW) after 9-day treatment. Silexan triggered neurite outgrowth and synaptogenesis in 2 different neuronal cell models and led to a significant increase in synaptogenesis in primary hippocampal neurons. Silexan led to a significant phosphorylation of protein kinase A and subsequent CREB phosphorylation. Conclusion Taken together, Silexan demonstrates antidepressant-like effects in cellular as well as animal models for antidepressant activity. Therefore, our data provides preclinical evidence for the clinical antidepressant effects of Silexan in patients with mixed depression and anxiety.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties

et al. 2020

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“…Lavender EO displayed a neuroprotective role in different in vitro and in vivo models of AD (Xu et al, 2016). In addition, lavender EO has been recently demonstrated to counteract anxiety by modulating voltage‐gated calcium channels (VGCC) (Schuwald et al, 2013) and to have a beneficial effect on neuroplasticity and neurogenesis (Sánchez‐Vidaña et al, 2019). C. sativum L. (coriander), a member of Umbelliferae/Apiaceae family, has been reported to have antioxidant, antiinflammatory, anticonvulsive properties, and to exert beneficial effects against Aβ 1‐42 toxicity.…”

Section: Introductionmentioning

confidence: 99%

Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid‐β neurotoxicity

Caputo

Piccialli

Ciccone

et al. 2020

Phytotherapy Research

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Alzheimer's disease (AD) is a neurodegenerative disorder leading to cognitive deficits and cognitive decline. Since no cure or preventing therapy is currently available to counteract AD, natural‐derived compounds are investigated to find new potential neuroprotective agents for its treatment. In the present study, we tested the neuroprotective effect of lavender and coriander essential oils (EOs) and their main active constituent linalool, against the neurotoxicity elicited by Aβ1‐42 oligomers, a key molecular factor in the neurodegeneration of AD. Importantly, our findings on neuronally differentiated PC12 cells exposed to Aβ1‐42 oligomers are in accordance with previous in vivo studies reporting the neuroprotective potential of lavender and coriander EOs and linalool. We found that lavender and coriander EOs at the concentration of 10 μg/mL as well as linalool at the same concentration were able to improve viability and to reduce nuclear morphological abnormalities in cells treated with Aβ1‐42 oligomers for 24 hours. Lavender and coriander EOs and linalool also showed to counteract the increase of intracellular reactive oxygen species production and the activation of the pro‐apoptotic enzyme caspase‐3 induced by Aβ1‐42 oligomers. Our findings provide further evidence that these EOs and their main constituent linalool could be natural agents of therapeutic interest against Aβ1‐42‐induced neurotoxicity.

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“…Furthermore, Sánchez-Vidaña et al indicated that inhalation of lavender essential oils ameliorates depression-like behaviour and increases neurogenesis in rats [ 22 ]. These relaxation effects of lavender are thought to arise from not only psychological effects but also physiological effects of the volatile components [ 23 ]. Lavender oil includes linalool and linalyl acetate as main components [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study

Ogata

Ataka

Suzuki

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. The aim of the present study was to assess the effects of lavender oil inhalation on blood pressure, pulse measurements, cortisol levels, depressive mood, and anxiety in healthy male adults. The mechanism was investigated by the action on oxytocin single neurons in the hypothalamus of rodents. Methods. The participants (n = 7) were aged 20–40 years. After randomisation, they received an inhaled dose of lavender oil or distilled water for 20 min. They received the other treatment after a washout period of one week. We assessed the outcomes using the Self-Rating Depression Scale, State-Trait Anxiety Inventory, and self-rated unidimensional Visual Analogue Scale for depression; anxiety; and hunger, thirst, and appetite, respectively. Blood pressure, pulse rate, and cortisol concentration in the peripheral blood were assessed before and after inhalation. In the rodent study (n = 4), oxytocin single neurons were isolated from the mouse hypothalamus. Intracellular Ca2+ concentration in the oxytocin neurons isolated from the hypothalamus was measured following direct administration of lavender oil. Results. Seven participants completed the study. Lavender inhalation decreased Self-Rating Depression Scale score and systolic and diastolic blood pressure. Ex vivo administration of lavender oil increased intracellular Ca2+ concentration in the hypothalamic oxytocin neurons. Conclusions. Lavender oil might be a useful therapy for stress relief, and its mechanism of action may include activation of the central oxytocin neurons.

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Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats

Cited by 65 publications

References 90 publications

Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties

Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties

Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid‐β neurotoxicity

Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study

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