Groundwater constitutes one of the main sources used to satisfy the water demands of the different users located in a basin. Current groundwater pumping rates in many cases exceed natural recharge, resulting in the overexploitation of aquifers and the deterioration of water quality. Consequently, many aquifer systems in the world have applied and adapted policies to manage the use of groundwater. In this article, we investigate the impacts of groundwater management policies on the Caplina aquifer located in the Atacama Desert, Peru. To evaluate these impacts, we review policies and regulations implemented during the last 40 years. Likewise, more than 25 scientific investigations that were carried out in this aquifer are reviewed and analyzed to understand its hydrodynamics and hydrochemistry, as well as the impact of climate change, among other aspects. The results, based on scientific evidence, show that the current and future conditions of the groundwater of the Caplina aquifer are not sustainable, and likewise, public policies are not effective for reversing this situation. This leads the aquifer system to a situation in which there is a quality degradation of the water, to a point that may be irreversible.