Lawesson's reagent promoted deoxygenation of azlactones for the syntheses of 2,4-disubstituted thiazoles

Abstract

Azlactones and thiazoles are common stuctural motifs and possess diverse applications. A new method for the efficient and straightforward syntheses of 2,4-disubstituted thiazoles from azlactones has been developed. The reaction...

Visible-light-induced C–S bond formation in the synthesis of 2,4-disubstituted thiazoles through cascade difunctionalization of acetophenone: a greener approach

“…[11][12][13] The synthesis of phenyl thiazole compounds has garnered substantial interest in therapeutic science due to their potential pharmacological importance. These compounds have demonstrated potent and noteworthy biological effects 14,15 similar to various existing drugs with well-established uses. For instance, they exhibit properties akin to anti-inflammatory drugs like meloxicam, 16 anticancer drugs like dasatinib, 17,18 antiparasitic drugs like nitazoxanide, 19 pesticide drugs like thiabendazole, 20 antimicrobial drugs like sulfathiazole, 21 antifungal drugs like abafungin, 22,23 antineoplastic drugs like guineamide, 24,25 broad-spectrum third-generation cephalosporin antibiotics, 26 anti-bacterial drugs like cefotaxime, inhibitors like fatostatin, vitamin B 1 , thiamine, and antiulcerogenic drugs like famotidine.…”

Enhancing C–S and C–N bond formation with ultrasound assistance: lipase-catalyzed synthesis of 2,4-disubstituted thiazole derivatives from arylethanones and thioamides

“…1. 11,12 The existence of these patterns in natural substances and their diverse biological functions has sparked interest in synthesizing them. 13,14 Nowadays, there are numerous methods for the synthesis of thiazole moiety.…”