Laxatives and the Special Role of Senna

Godding, Edmund W.

doi:10.1159/000138445

Cited by 17 publications

(10 citation statements)

References 5 publications

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“…Thus sennosides are not absorbed in the upper gastrointestinal tract. The β‐glucosidase of enteric bacteria hydrolyze sennosides into rhein mono‐anthrones, which become active when they reach the large bowel . This active drug then induces a rapid increase in the motility of the colon , causing 3 to 10 high‐amplitude contractions that occur 6 to 10 hours after ingestion.…”

Section: Discussionmentioning

confidence: 99%

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Contact Burn with Blister Formation in Children Treated with Sennosides

Cogley

Echevarria

Correa

et al. 2017

Pediatric Dermatology

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Eight children treated for severe constipation with sennosides unexpectedly developed contact burns with blisters secondary to the use of these laxatives. All patients wore diapers, and the injuries occurred overnight. To avoid this side effect, we recommend that patients treated with sennosides, especially those in diapers, receive the medication at a time that allows for bowel movements to occur during the day and not overnight.

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Section: Discussionmentioning

confidence: 99%

“…We treat patients with idiopathic constipation and constipation due to anorectal malformations and Hirschsprung's disease. The choice between osmotic and stimulant laxatives is made according to the condition of the patient . We prefer to use sennosides, a stimulant laxative with particular effect on colonic motility.…”

mentioning

confidence: 99%

Contact Burn with Blister Formation in Children Treated with Sennosides

Cogley

Echevarria

Correa

et al. 2017

Pediatric Dermatology

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“…Its main pharmacological components are the sennosides. Sennosides are decomposed into rheinanthrone by bacteria in the colon, and then stimulate Auerbach's plexus to exert their laxative effects (Godding, 1988).…”

Section: Discussionmentioning

confidence: 99%

Immunological changes in the intestines and skin after senna administration

Yamate

Hiramoto

Yokoyama

et al. 2014

Pharmaceutical Biology

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Context: It has been reported that chronic sennoside use is associated with the development of melanosis coli, colonic adenoma, and/or carcinomas. Objectives: In this study, we investigated the immunological changes in the colon and skin after the administration of senna. Materials and methods: In this study, we investigated the colon and epidermis of C57/BL6j mice after a single administration of 10 mg/kg of senna [Cassia angustifolia (Caesalpiniaceae); 3, 6, 12, and 24 h after administration] and after repeated once per week administrations (on days 3, 5, 7, 14, and 21 of administration). The LD 50 and ED 50 of senna used in this experiment were 165 mg/kg and 13 g/kg, respectively. Results: We demonstrated that the DOPA-positive cells in the colon increased at 12 h after single administration and were further increased from at 5-28 d after repeated administration. We also studied the physiological changes of the small intestine using the charcoal meal test. We found that there was a tendency for peristalsis to be inhibited after repeated senna administration. In the epidermis, we investigated the number of Langerhans cells, because they are important immune cells of the skin. The number of these cells decreased, especially after repeated administration. Discussion and conclusion: The present findings suggested that it is necessary to pay attention to not only the intestine but also the skin, during long-term senna treatment.

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“…These are degraded in the lower reaches of the gastrointestinal tract only and act for the most part by inducing a net secretion of fluid into the colon . They are also direct stimulants to nerve endings in the colonic mucosa, increasing motility and enhancing colonic transit . While the active principles may appear in breast milk, the amounts are probably insufficient to cause diarrhoea in a breastfed child .…”

mentioning

confidence: 99%

“…They are also direct stimulants to nerve endings in the colonic mucosa, increasing motility and enhancing colonic transit . While the active principles may appear in breast milk, the amounts are probably insufficient to cause diarrhoea in a breastfed child . Senna comes in different preparations – granules, capsules, tablets and chocolate squares.…”

mentioning

confidence: 99%