Layer-by-layer dip coating of Foley urinary catheters by chlorhexidine-loaded micelles

Srisang, Siriwan; Nasongkla, Norased

doi:10.1016/j.jddst.2018.11.019

Cited by 34 publications

(22 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly, LbL technology presented several advantages for biomedicine: (i) deposition of homogeneous films with controlled thickness, (ii) high loading capacities and controlled release of biomolecules/drugs of various nature, and (iii) coating stability under physiological conditions. This made the LbL method one of the most rapidly growing strategies for generating thin film coatings of biomedical scaffolds [ 3 , 4 , 5 , 6 ], patterned surfaces [ 7 , 8 ], medical devices [ 9 , 10 ], implants [ 11 , 12 ], and a range of alternate bioapplications ( Figure 1 ); while multilayer capsules became promising nano- and micro-carriers for drug delivery applications [ 1 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ].…”

Section: Biopolymer-based Multilayersmentioning

confidence: 99%

Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics

Campbell

Vikulina

2020

Polymers

View full text Add to dashboard Cite

Rapid development of versatile layer-by-layer technology has resulted in important breakthroughs in the understanding of the nature of molecular interactions in multilayer assemblies made of polyelectrolytes. Nowadays, polyelectrolyte multilayers (PEM) are considered to be non-equilibrium and highly dynamic structures. High interest in biomedical applications of PEMs has attracted attention to PEMs made of biopolymers. Recent studies suggest that biopolymer dynamics determines the fate and the properties of such PEMs; however, deciphering, predicting and controlling the dynamics of polymers remains a challenge. This review brings together the up-to-date knowledge of the role of molecular dynamics in multilayers assembled from biopolymers. We discuss how molecular dynamics determines the properties of these PEMs from the nano to the macro scale, focusing on its role in PEM formation and non-enzymatic degradation. We summarize the factors allowing the control of molecular dynamics within PEMs, and therefore to tailor polymer multilayers on demand.

show abstract

Section: Biopolymer-based Multilayersmentioning

confidence: 99%

Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics

Campbell

Vikulina

2020

Polymers

View full text Add to dashboard Cite

show abstract

“…Previously, we reported CHX‐loaded PCL nanospheres and CHX‐loaded PEG‐ b‐ PCL micelles coated on urinary catheter; however, both systems released CHX within 2 weeks 5,6,20 and provided limitation of CHX quantity on the catheter's surface and caused the burst release of CHX (> 30%) on the first day. Hence, in this study, we combined CHX‐loaded PEG‐ b‐ PCL micelles and CHX‐loaded PCL nanospheres to coat on urinary catheters and provided a prolonged CHX release up to 1 month with high antibacterial potential 7 .…”

Section: Methodsmentioning

confidence: 96%

“…A urinary catheter is surface device and depends on the contact duration (limited, prolonged, and permanent). It must be tested to evaluate its cytotoxicity, sensitization, irritation, and hemolysis to confirm its biosafety 1‐8 . A long‐term catheterization is called an indwelling catheterization, which allows bacteria in the urinary tract try to dwell on the catheter surface and then become a biofilm, which results in infection.…”

Section: Introductionmentioning

confidence: 99%

“…It must be tested to evaluate its cytotoxicity, sensitization, irritation, and hemolysis to confirm its biosafety. [1][2][3][4][5][6][7][8] A long-term catheterization is called an indwelling catheterization, which allows bacteria in the urinary tract try to dwell on the catheter surface and then become a biofilm, which results in infection. Various reports have presented strategies to prevent biofilm formation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biocompatibility and stability during storage of Foley urinary catheters coated chlorhexidine loaded nanoparticles by nanocoating: in vitro and in vivo evaluation

et al. 2020

Self Cite

View full text Add to dashboard Cite

Foley urinary catheters were coated by chlorhexidine‐loaded micelles and chlorhexidine‐loaded nanospheres. In our prior study, the nanocoating of Foley urinary catheter was investigated for chlorhexidine‐release study, degradation, antibacterial evaluation, and cytotoxicity assessment. These studies presented the 1 month antibacterial property of nanocoating deposited via the layers of micelles and nanospheres. In this study, we evaluated the biocompatibility of these catheters, including hemocompatibility, skin irritation, skin sensitization, and stability during the age of coated urinary catheter. Results demonstrated that coated urinary catheters presented slight hemolysis, whereas skin irritation on rabbit and skin sensitization on Dunkin Hartley guinea pig showed no signs of dermal toxicity, which indicated that inflammation, redness, and swelling did not occur. Moreover, the stability of coated urinary catheters during storage indicated no change in chlorhexidine peaks by high performance liquid chromatography. Information from these studies supports the biocompatibility of coated urinary catheters via nanocoating and their use as indwelling devices to prevent urinary tract infections.

show abstract

“…The first is to decorate the surface with quaternary ammonium polymers that interfere with the bacteria cell wall leading to cell lysis and death [12, 13, 14]. However, the second approach relies on loading the surface with biocidal agents such as antibiotic, antiseptic, enzymes or metallic nanoparticles that under go slow release to the near surroundings causing bacterial death [15, 16, 17, 18].…”

Section: Introductionmentioning

confidence: 99%

Facile coating of urinary catheter with bio–inspired antibacterial coating

Yassin

Elkhooly

Elsherbiny

et al. 2019

Heliyon

View full text Add to dashboard Cite

A B S T R A C TFormation of bacterial biofilm on indwelling urinary catheters usually causes catheter-associated urinary tract infections (CAUTIs) that represent high percent of nosocomial infections worldwide. Therefore, coating urinary catheter with antibacterial and antifouling coating using facile technique is in great demand. In this study, commercial urinary catheter was coated with a layer of the self-polymerized polydopamine which acts as active platform for the in situ formation of silver nanoparticle (AgNPs) on catheter surface. The formed coating was intensively characterized using spectroscopic and microscopic techniques. The coated catheter has the potential to release silver ion in a sustained manner with a concentration of about 2-4 μg ml À1 . Disk diffusion test and colony forming unites assay verified the significant bactericidal potential of the AgNPs coated catheter against both gram-positive and gram-negative bacteria as a consequence of silver ion release. In contrast to commercial catheter, the AgNPs coated catheter prevented the adherence of bacterial cells and biofilm formation on their surfaces. Interestingly, scanning electron microscope investigations showed that AgNPs coated catheter possess greater antifouling potential against gram-positive bacteria than against gram-negative bacteria. Overall, the remarkable antibacterial and antifouling potential of the coated catheter supported the use of such facile approach for coating of different medical devices for the prevention of nosocomial infections.

show abstract

Layer-by-layer dip coating of Foley urinary catheters by chlorhexidine-loaded micelles

Cited by 34 publications

References 34 publications

Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics

Layer-By-Layer Assemblies of Biopolymers: Build-Up, Mechanical Stability and Molecular Dynamics

Biocompatibility and stability during storage of Foley urinary catheters coated chlorhexidine loaded nanoparticles by nanocoating: in vitro and in vivo evaluation

Facile coating of urinary catheter with bio–inspired antibacterial coating

Contact Info

Product

Resources

About