Layer-by-layer self-assembly of MoS2/PDDA hybrid film in microfluidic chips for ultrasensitive electrochemical immunosensing of alpha-fetoprotein

Hu, Tao; Zhang, Man; Wang, Zhen; Chen, Ke; Li, Xiao; Zhang, Ni

doi:10.1016/j.microc.2020.105209

Cited by 23 publications

(6 citation statements)

References 31 publications

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“…The biosensor can sensitively detect tumour necrosis factor-α (TNF-α) between 1-200 pg/mL, with an LOD as low as 0.202 pg/mL (Figure 4c). Hu et al [90] first prepared MoS 2 by liquid-phase exfoliation and formed a hybrid film with PDDA, designed a three-electrode system in the microfluidic chip, and introduced a MoS 2 /PDDA film modified with anti-AFP as the working electrode, Ag/AgCl as the reference electrode, and ITO as the counter electrode (Figure 4d). The linear range of AFP detected by EIS was 0.1 ng/mL to 10 ng/mL, with an LOD of 0.033 ng/mL.…”

Section: Impedimetrymentioning

confidence: 99%

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarkers Detection: A Review

Qin¹,

Zhang²,

Li³

2023

Preprint

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Cancer is a common illness with a high mortality. Compared to traditional technologies, biomarkers detection, with low cost and simple operation, has higher sensitivity and faster speed in early screening and prognosis of cancer. Therefore, extensive research has been focused on the development of biosensors and the construction of sensing interfaces. Molybdenum disulfide (MoS2) is a promising two-dimensional (2D) nanomaterial, whose unique adjustable bandgap shows excellent electronic and optical properties in the construction of biosensor interfaces. It not only has the advantages of high catalytic activity and low manufacturing costs, but also can further expand the application of hybrid structures by different functionalization, and is widely used in various biosensors fields. Herein, the application of electrochemical and optical sensing platforms based on MoS2 in the detection of cancer biomarkers was comprehensively reviewed. Firstly, the structure and preparation method of MoS2 were introduced, and its applicable characteristics in the field of biosensors were explored. Secondly, we comprehensively reviewed the recent construction and application of sensing platform based on MoS2 in the field of cancer biomarkers detection in both electrochemical and optical aspects. The prime characteristics and application performances of MoS2 and its composites were emphasized. Additionally, we also involved some other types of biosensors based on MoS2. Finally, we summarized the challenges and development prospects of MoS2 in the application of cancer biomarkers detection, and provided some insights for the application potential of this kind of emerging nano-materials in a broader field.

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Section: Impedimetrymentioning

confidence: 99%

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarkers Detection: A Review

Qin¹,

Zhang²,

Li³

2023

Preprint

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“…The biosensor can sensitively detect tumour necrosis factor-α (TNF-α) between 1–200 pg/mL, with an LOD as low as 0.202 pg/mL ( Figure 4 c). Hu et al [ 90 ] first prepared MoS 2 by liquid-phase exfoliation and formed a hybrid film with PDDA, designed a three-electrode system in the microfluidic chip, and introduced a MoS 2 /PDDA film modified with anti-AFP as the working electrode, Ag/AgCl as the reference electrode, and ITO as the counter electrode ( Figure 4 d). The linear range of AFP detected by EIS was 0.1 ng/mL to 10 ng/mL, with an LOD of 0.033 ng/mL.…”

Section: Electrochemical Biosensors For Cancer Biomarkers Detection B...mentioning

confidence: 99%

“…Copyright 2022, Elsevier. ( d ) Schematic illustration for self-assembly of MoS 2 /PDDA hybrid film, microfluidic chip fabrication, anti-AFP immobilization, and electrochemical detection of AFP [ 90 ]. Copyright 2020, Elsevier.…”

Section: Electrochemical Biosensors For Cancer Biomarkers Detection B...mentioning

confidence: 99%

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarker Detection: A Review

Qin,

Zhang,

2023

Biosensors

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Cancer is a common illness with a high mortality. Compared with traditional technologies, biomarker detection, with its low cost and simple operation, has a higher sensitivity and faster speed in the early screening and prognosis of cancer. Therefore, extensive research has focused on the development of biosensors and the construction of sensing interfaces. Molybdenum disulfide (MoS2) is a promising two-dimensional (2D) nanomaterial, whose unique adjustable bandgap shows excellent electronic and optical properties in the construction of biosensor interfaces. It not only has the advantages of a high catalytic activity and low manufacturing costs, but it can also further expand the application of hybrid structures through different functionalization, and it is widely used in various biosensors fields. Herein, we provide a detailed introduction to the structure and synthesis methods of MoS2, and explore the unique properties and advantages/disadvantages exhibited by different structures. Specifically, we focus on the excellent properties and application performance of MoS2 and its composite structures, and discuss the widespread application of MoS2 in cancer biomarkers detection from both electrochemical and optical dimensions. Additionally, with the cross development of emerging technologies, we have also expanded the application of other emerging sensors based on MoS2 for early cancer diagnosis. Finally, we summarized the challenges and prospects of MoS2 in the synthesis, functionalization of composite groups, and applications, and provided some insights into the potential applications of these emerging nanomaterials in a wider range of fields.

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“…Moreover, the immunochip was used to detect AFP in human serum samples. It also proved to have high selectivity when analyzing small volumes, which could be useful in the trace detection of AFP [11]. An electrochemical aptasensor was built using a hierarchical MoS 2 nanostructure functionalized with SiO 2 nanoprobes and capped with a DNA probe.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS₂ nanosheets

Zniber¹,

Vahdatiyekta²,

Roy³

et al. 2022

Nano Futures

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Two-dimensional transition metal dichalcogenides (2D TMDs) have gained considerable attention from the scientific community for their various applications thanks to their remarkable chemical, physical, optical and electronic properties. In this study, MoS2 nanosheets were synthesized using a kitchen blender with the assistance of a surfactant so-called Pluronic F127 through a shear-exfoliation process. Different techniques were used to characterize the chemical composition, nanostructure, and electrochemical properties of the synthesized MoS2-F127 as well as Pt modified with MoS2-F127 (Pt/MoS2-F127) electrode. The Pt/MoS2-F127 electrode combined with differential pulse voltammetry was used for the electrochemical detection of homovanillic acid (HVA) in the presence of common interferents in urine. The study provides a new approach to discriminate the electrochemical signal of HVA and UA which lead to higher selectivity of the sensor.

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Layer-by-layer self-assembly of MoS2/PDDA hybrid film in microfluidic chips for ultrasensitive electrochemical immunosensing of alpha-fetoprotein

Cited by 23 publications

References 31 publications

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarkers Detection: A Review

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarkers Detection: A Review

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarker Detection: A Review

Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS₂ nanosheets

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Layer-by-layer self-assembly of MoS2/PDDA hybrid film in microfluidic chips for ultrasensitive electrochemical immunosensing of alpha-fetoprotein

Cited by 23 publications

References 31 publications

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarkers Detection: A Review

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarkers Detection: A Review

Molybdenum Disulfide as Tunable Electrochemical and Optical Biosensing Platforms for Cancer Biomarker Detection: A Review

Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS2 nanosheets

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Electrochemical detection of homovanillic acid, a breast cancer biomarker, using Pluronic-modified MoS₂ nanosheets